Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 4820652..4821187 Replicon chromosome
Accession NZ_CP020350
Organism Pectobacterium brasiliense strain SX309

Toxin (Protein)


Gene name relE Uniprot ID C6DJA0
Locus tag B5S52_RS21650 Protein ID WP_015842269.1
Coordinates 4820900..4821187 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q6DB37
Locus tag B5S52_RS21645 Protein ID WP_010281712.1
Coordinates 4820652..4820903 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B5S52_RS21615 4816090..4816416 + 327 WP_039510297.1 helix-turn-helix domain-containing protein -
B5S52_RS21620 4816401..4816715 + 315 WP_039463512.1 HipA N-terminal domain-containing protein -
B5S52_RS21625 4816712..4817752 + 1041 WP_039510294.1 HipA domain-containing protein -
B5S52_RS21630 4817812..4818435 - 624 WP_039510292.1 LysE family translocator -
B5S52_RS21635 4818703..4819458 + 756 WP_039510290.1 thiol:disulfide interchange protein DsbG -
B5S52_RS21640 4819492..4820397 - 906 WP_039501750.1 siderophore-interacting protein -
B5S52_RS21645 4820652..4820903 + 252 WP_010281712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
B5S52_RS21650 4820900..4821187 + 288 WP_015842269.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
B5S52_RS21655 4821867..4823828 - 1962 WP_205939775.1 hypothetical protein -
B5S52_RS21660 4824330..4825682 - 1353 WP_039510287.1 glutathione-disulfide reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11074.15 Da        Isoelectric Point: 10.3527

>T74348 WP_015842269.1 NZ_CP020350:4820900-4821187 [Pectobacterium brasiliense]
MSYSVKFREDALKEWLKLDKTIQQQFAKKLKKCCENPHIPSAKLRGMKDCYKIKLRASGFRLVYEVIDDVLIIAVVAVGK
RERSGVYHLASERMR

Download         Length: 288 bp

>T74348 NZ_CP020350:4820900-4821187 [Pectobacterium brasiliense]
ATGAGCTATAGCGTCAAATTCAGGGAAGATGCGCTGAAAGAATGGCTCAAGCTCGATAAAACCATCCAGCAGCAATTTGC
CAAAAAACTAAAAAAATGCTGCGAAAATCCCCATATTCCTTCGGCAAAGTTACGAGGGATGAAGGACTGCTACAAAATAA
AGCTCCGAGCATCAGGCTTTCGTTTGGTTTATGAGGTTATTGACGACGTATTGATTATCGCCGTAGTGGCGGTAGGTAAA
CGTGAGCGCAGCGGTGTTTATCATCTGGCGAGTGAGCGAATGAGATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9117.47 Da        Isoelectric Point: 4.0637

>AT74348 WP_010281712.1 NZ_CP020350:4820652-4820903 [Pectobacterium brasiliense]
MPNIILSDTSASVSELKKNPMATVNAGDGLPVAILNRNQPAFYCIPADLYEKMLDALDDQELVKLIGERKNQPLVDVDLD
SFL

Download         Length: 252 bp

>AT74348 NZ_CP020350:4820652-4820903 [Pectobacterium brasiliense]
ATGCCGAATATTATATTGAGTGATACCAGTGCCAGCGTCAGTGAACTGAAAAAGAACCCAATGGCGACGGTCAATGCTGG
CGATGGCCTGCCTGTCGCTATTTTGAACCGCAACCAGCCTGCGTTTTATTGCATTCCTGCGGATCTCTACGAAAAAATGC
TGGATGCGCTGGACGATCAAGAACTGGTTAAGCTAATCGGTGAACGTAAAAACCAGCCACTGGTTGACGTGGATTTGGAT
AGTTTCCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S0XQ75

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2EZP0

References