74346

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-DnaT
Location 4515184..4515715 Replicon chromosome
Accession NZ_CP020350
Organism Pectobacterium brasiliense strain SX309

Toxin (Protein)


Gene name stbE Uniprot ID A0A086EVU3
Locus tag B5S52_RS20205 Protein ID WP_039282785.1
Coordinates 4515184..4515471 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A1V2R9J2
Locus tag B5S52_RS20210 Protein ID WP_039282788.1
Coordinates 4515461..4515715 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B5S52_RS20185 4510645..4512036 + 1392 WP_039522250.1 outer membrane channel protein TolC -
B5S52_RS20190 4512306..4512980 + 675 WP_010280216.1 DUF1190 family protein -
B5S52_RS20195 4512992..4514152 + 1161 WP_040038102.1 glutathionylspermidine synthase family protein -
B5S52_RS20200 4514220..4515005 - 786 WP_010280213.1 4,5-DOPA dioxygenase extradiol -
B5S52_RS20205 4515184..4515471 - 288 WP_039282785.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
B5S52_RS20210 4515461..4515715 - 255 WP_039282788.1 plasmid stabilization protein Antitoxin
B5S52_RS20225 4516430..4517317 - 888 WP_040038101.1 16S rRNA (cytidine(1402)-2'-O)-methyltransferase -
B5S52_RS20230 4517379..4519397 + 2019 WP_040038100.1 penicillin-binding protein activator -
B5S52_RS20235 4519355..4519750 + 396 WP_072009247.1 YraN family protein -
B5S52_RS20240 4519814..4520404 + 591 WP_005975525.1 DnaA initiator-associating protein DiaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11011.96 Da        Isoelectric Point: 10.7694

>T74346 WP_039282785.1 NZ_CP020350:c4515471-4515184 [Pectobacterium brasiliense]
MTYKLKFVPSAMKEWKKLGHPVREQFKKKLVERLENPRVPSAQLHGRKDQYKIKLKSAGYRLVYLVQDETITVMVMGVGK
REGSQIYSDTKGRSA

Download         Length: 288 bp

>T74346 NZ_CP020350:c4515471-4515184 [Pectobacterium brasiliense]
ATGACCTATAAGTTAAAATTTGTGCCTTCTGCAATGAAGGAATGGAAAAAGCTAGGGCATCCTGTCCGGGAACAGTTCAA
GAAAAAGCTGGTTGAGCGTTTGGAAAATCCTCGTGTTCCTTCAGCCCAGCTTCATGGCCGTAAAGACCAGTATAAAATTA
AACTGAAGTCCGCTGGCTACAGGCTGGTGTATTTGGTTCAGGATGAGACCATTACTGTGATGGTTATGGGAGTTGGAAAG
CGCGAAGGTAGCCAGATTTATTCTGATACGAAAGGTCGCTCTGCTTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9208.38 Da        Isoelectric Point: 3.7947

>AT74346 WP_039282788.1 NZ_CP020350:c4515715-4515461 [Pectobacterium brasiliense]
MAFNILTNTAASITELKRDPMGTVRAAEGETIAILNRNEPAFYCVPPAVFAYLMELAEDAELGRTVDDRMSELADAEEIS
LDDL

Download         Length: 255 bp

>AT74346 NZ_CP020350:c4515715-4515461 [Pectobacterium brasiliense]
ATGGCTTTCAACATCCTAACTAACACAGCCGCCAGTATTACTGAGTTGAAACGTGACCCGATGGGGACGGTTCGGGCTGC
TGAAGGTGAAACTATCGCTATACTGAACCGGAATGAGCCGGCGTTCTACTGTGTGCCTCCTGCTGTATTCGCCTATTTAA
TGGAACTGGCTGAAGATGCAGAACTGGGGCGTACCGTTGATGATAGGATGTCAGAGCTAGCTGACGCGGAAGAGATTTCG
CTCGATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A086EVU3

Antitoxin

Source ID Structure
AlphaFold DB A0A1V2R9J2

References