Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4278010..4278536 Replicon chromosome
Accession NZ_CP020350
Organism Pectobacterium brasiliense strain SX309

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag B5S52_RS19160 Protein ID WP_039308945.1
Coordinates 4278231..4278536 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag B5S52_RS19155 Protein ID WP_039308948.1
Coordinates 4278010..4278228 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B5S52_RS19130 4274230..4275489 + 1260 WP_039302994.1 integrase arm-type DNA-binding domain-containing protein -
B5S52_RS19135 4275584..4275778 - 195 WP_012773549.1 DUF3950 domain-containing protein -
B5S52_RS19140 4275964..4276305 + 342 WP_039302990.1 hypothetical protein -
B5S52_RS19150 4277208..4277951 + 744 WP_039308950.1 hypothetical protein -
B5S52_RS19155 4278010..4278228 + 219 WP_039308948.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
B5S52_RS19160 4278231..4278536 + 306 WP_039308945.1 type II toxin-antitoxin system toxin CcdB Toxin
B5S52_RS19165 4278924..4279463 + 540 WP_039308942.1 SLATT domain-containing protein -
B5S52_RS19170 4279456..4280829 + 1374 WP_039308940.1 reverse transcriptase -
B5S52_RS19175 4280995..4282368 - 1374 WP_039308937.1 deoxyguanosinetriphosphate triphosphohydrolase family protein -
B5S52_RS19180 4282840..4283409 + 570 WP_197061602.1 DNA adenine methylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 4274052..4288331 14279


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11775.63 Da        Isoelectric Point: 4.6873

>T74342 WP_039308945.1 NZ_CP020350:4278231-4278536 [Pectobacterium brasiliense]
MQFIVYQYKRASHYKMFVDVQSDIVETPKRRMVIPLLEAHHLSEKVNKTLFPLIRIDGEDYRLMTTELSSVPVEVIGEEI
ADLGDYADEIKDAINLMFWGI

Download         Length: 306 bp

>T74342 NZ_CP020350:4278231-4278536 [Pectobacterium brasiliense]
ATGCAATTCATTGTTTATCAATACAAACGTGCCAGTCACTACAAAATGTTTGTCGATGTGCAGAGTGATATTGTCGAGAC
ACCGAAGCGGCGCATGGTTATCCCGCTTCTAGAAGCACATCACCTGTCTGAGAAAGTGAATAAGACGTTGTTTCCTCTGA
TTCGCATCGACGGCGAAGATTATCGGTTGATGACTACTGAACTATCGAGCGTTCCGGTTGAGGTCATTGGTGAAGAAATT
GCGGATCTTGGCGACTACGCTGATGAGATCAAGGATGCTATCAATCTTATGTTTTGGGGGATTTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8186.19 Da        Isoelectric Point: 7.2038

>AT74342 WP_039308948.1 NZ_CP020350:4278010-4278228 [Pectobacterium brasiliense]
MKHRVSVTVDKDNYQVLSAAGVNISGLVNDAIGKEARRIKAEEWKKENREGMEEVARFIALHGSFADENRNW

Download         Length: 219 bp

>AT74342 NZ_CP020350:4278010-4278228 [Pectobacterium brasiliense]
ATGAAACACCGCGTCAGCGTTACCGTGGACAAAGACAATTATCAGGTTCTGAGTGCTGCCGGAGTCAATATTTCTGGGCT
GGTGAATGATGCCATTGGCAAAGAAGCCCGCCGCATCAAGGCTGAGGAGTGGAAGAAGGAAAACCGCGAAGGGATGGAAG
AAGTCGCCCGATTTATCGCACTGCATGGCTCCTTTGCGGATGAAAACAGGAACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References