Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4124530..4125190 Replicon chromosome
Accession NZ_CP020350
Organism Pectobacterium brasiliense strain SX309

Toxin (Protein)


Gene name cptA Uniprot ID A0A837DIN4
Locus tag B5S52_RS18365 Protein ID WP_039275532.1
Coordinates 4124530..4124943 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A1D7Z1Z6
Locus tag B5S52_RS18370 Protein ID WP_005971623.1
Coordinates 4124924..4125190 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B5S52_RS18340 4120331..4121659 + 1329 WP_039282120.1 MHS family MFS transporter -
B5S52_RS18345 4121864..4122250 + 387 WP_039282122.1 thioesterase family protein -
B5S52_RS18350 4122590..4123108 + 519 WP_039510708.1 flavodoxin FldB -
B5S52_RS18355 4123137..4123460 + 324 WP_039510707.1 hypothetical protein -
B5S52_RS18360 4123526..4124461 - 936 WP_039510706.1 23S rRNA (adenine(1618)-N(6))-methyltransferase RlmF -
B5S52_RS18365 4124530..4124943 - 414 WP_039275532.1 protein YgfX Toxin
B5S52_RS18370 4124924..4125190 - 267 WP_005971623.1 FAD assembly factor SdhE Antitoxin
B5S52_RS18375 4125426..4126427 + 1002 WP_014914175.1 tRNA-modifying protein YgfZ -
B5S52_RS18380 4126482..4127129 - 648 WP_010279833.1 hemolysin III family protein -
B5S52_RS18385 4127560..4128168 + 609 WP_014914174.1 HD domain-containing protein -
B5S52_RS18390 4128223..4129227 + 1005 WP_039510704.1 LacI family DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-132)

Antitoxin

Flavinator of succinate dehydrogenase

(8-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16311.26 Da        Isoelectric Point: 10.7911

>T74341 WP_039275532.1 NZ_CP020350:c4124943-4124530 [Pectobacterium brasiliense]
VAQWRCDLRVSWRMQLLSLVVHGLLVLLILLAPWPDGYAWLWLCLVTMVMFGFIRSQRNIKSRQGEIVLLSETTLNWRQQ
EWQIVKRPWLLKNGVLLSLQAVNGKDKQQLWLASDSMGDDEWRHLRQILLQQKHWAR

Download         Length: 414 bp

>T74341 NZ_CP020350:c4124943-4124530 [Pectobacterium brasiliense]
GTGGCCCAGTGGCGATGTGACCTTCGCGTTTCCTGGCGCATGCAACTGTTATCATTGGTTGTGCATGGCCTATTAGTATT
GCTCATTCTGCTGGCACCCTGGCCGGACGGCTATGCGTGGCTATGGCTATGCCTGGTCACGATGGTGATGTTCGGTTTTA
TCCGTAGCCAACGGAATATTAAATCCCGACAGGGGGAAATCGTTCTGCTCAGCGAAACGACCCTGAACTGGCGGCAGCAG
GAATGGCAGATCGTTAAACGACCGTGGTTGCTGAAGAATGGCGTATTACTGTCATTGCAAGCGGTTAACGGTAAAGACAA
GCAGCAGCTGTGGCTGGCATCGGACAGCATGGGCGATGACGAATGGCGTCACTTGCGTCAAATTCTTTTGCAGCAGAAAC
ACTGGGCAAGATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10507.94 Da        Isoelectric Point: 5.1392

>AT74341 WP_005971623.1 NZ_CP020350:c4125190-4124924 [Pectobacterium brasiliense]
MEIDNKSRIHWACRRGMRELDIAIMPFFEHDYDTLNDTDKRTFVRLLQSDDPDLFNWLMNHGEPEDGELKRMISLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT74341 NZ_CP020350:c4125190-4124924 [Pectobacterium brasiliense]
ATGGAAATCGATAATAAATCACGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAATTGGATATCGCGATCATGCCGTT
TTTTGAGCATGACTATGACACACTTAATGACACTGATAAGCGCACGTTTGTACGCTTGTTACAAAGCGACGATCCCGATT
TATTCAACTGGCTGATGAACCACGGTGAACCGGAGGACGGAGAGCTGAAACGCATGATTTCCCTTATTCAGACGCGAAAT
AAAGATCGTGGCCCAGTGGCGATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837DIN4

Antitoxin

Source ID Structure
AlphaFold DB A0A1D7Z1Z6

References