Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 171081..171715 Replicon chromosome
Accession NZ_CP020350
Organism Pectobacterium brasiliense strain SX309

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag B5S52_RS00770 Protein ID WP_080162911.1
Coordinates 171081..171356 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A433N1R7
Locus tag B5S52_RS00775 Protein ID WP_014917022.1
Coordinates 171353..171715 (+) Length 121 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B5S52_RS00755 168101..169471 - 1371 WP_010281575.1 envelope stress sensor histidine kinase CpxA -
B5S52_RS00760 169468..170166 - 699 WP_010281574.1 envelope stress response regulator transcription factor CpxR -
B5S52_RS00765 170320..170844 + 525 WP_040043768.1 cell-envelope stress modulator CpxP -
B5S52_RS00770 171081..171356 + 276 WP_080162911.1 type II toxin-antitoxin system HicA family toxin Toxin
B5S52_RS00775 171353..171715 + 363 WP_014917022.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
B5S52_RS00780 172089..173276 + 1188 WP_080162913.1 sugar transporter -
B5S52_RS00785 173339..174241 + 903 WP_039499852.1 CDF family cation-efflux transporter FieF -
B5S52_RS00790 174448..175410 + 963 WP_010306854.1 6-phosphofructokinase -
B5S52_RS00795 175691..176575 + 885 WP_080162915.1 N-carbamoylputrescine amidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-85)

Antitoxin

Uncharacterised protein family HicB

(61-113)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10024.61 Da        Isoelectric Point: 11.1875

>T74335 WP_080162911.1 NZ_CP020350:171081-171356 [Pectobacterium brasiliense]
MQGKIASLRKKQRETLSQIFKTPVLSGVKWSNIESLVTALGGEIKEGSGSRVRFLLNGSIARFHRPHPSPDTDKGALVSL
REWLESIGVKP

Download         Length: 276 bp

>T74335 NZ_CP020350:171081-171356 [Pectobacterium brasiliense]
ATGCAGGGAAAGATAGCCAGCCTACGAAAGAAGCAGCGGGAAACGCTGAGCCAAATTTTCAAAACACCAGTACTTTCAGG
TGTTAAATGGTCGAATATTGAGTCACTCGTTACTGCGTTAGGCGGTGAAATTAAGGAAGGTAGCGGATCACGAGTGCGAT
TTTTATTGAACGGGAGTATCGCCCGATTCCATCGTCCTCATCCGTCACCGGATACTGATAAAGGCGCACTGGTTAGCCTG
CGTGAATGGCTGGAAAGTATAGGAGTAAAACCATGA

Antitoxin


Download         Length: 121 a.a.        Molecular weight: 13504.31 Da        Isoelectric Point: 4.4969

>AT74335 WP_014917022.1 NZ_CP020350:171353-171715 [Pectobacterium brasiliense]
MTKALNTPNTMVVSGQPAIISYVPEMGMFRGKFIGLSGYCDFVADSINGLRSEGEISLREYLEDCQENGIEPYEREEKVK
TFTLRYPESFGERLTIAAAERQISVNTFIVETLSEHLKQA

Download         Length: 363 bp

>AT74335 NZ_CP020350:171353-171715 [Pectobacterium brasiliense]
ATGACGAAAGCACTCAACACACCAAATACGATGGTTGTTTCTGGACAACCGGCCATTATCAGTTATGTACCGGAAATGGG
TATGTTTCGCGGTAAGTTTATTGGTTTATCTGGCTACTGTGATTTTGTCGCCGACAGTATTAATGGCTTGAGAAGCGAGG
GTGAAATTTCGCTACGCGAATATCTGGAAGACTGTCAGGAAAATGGCATTGAACCTTACGAGCGTGAAGAGAAGGTGAAA
ACATTCACCCTCCGTTATCCTGAATCATTCGGGGAACGACTGACCATTGCGGCCGCTGAACGCCAAATTTCAGTGAATAC
GTTTATTGTTGAAACACTTAGCGAACACCTGAAACAGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A433N1R7

References