Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 3891390..3892185 | Replicon | chromosome |
| Accession | NZ_CP020342 | ||
| Organism | Shigella flexneri 1a strain 0439 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | Q93EZ7 |
| Locus tag | BS647_RS21100 | Protein ID | WP_000854917.1 |
| Coordinates | 3891390..3891764 (-) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | D2ACA1 |
| Locus tag | BS647_RS21105 | Protein ID | WP_001280958.1 |
| Coordinates | 3891811..3892185 (-) | Length | 125 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BS647_RS21065 (3886999) | 3886999..3887937 | - | 939 | Protein_3820 | glyoxylate/hydroxypyruvate reductase GhrA | - |
| BS647_RS21075 (3888409) | 3888409..3888690 | - | 282 | Protein_3821 | DUF4942 domain-containing protein | - |
| BS647_RS21080 (3888972) | 3888972..3889976 | - | 1005 | WP_001179707.1 | IS110-like element ISSfl8 family transposase | - |
| BS647_RS21085 (3890048) | 3890048..3890608 | - | 561 | Protein_3823 | DUF4942 domain-containing protein | - |
| BS647_RS21090 (3890693) | 3890693..3890890 | - | 198 | WP_000839282.1 | DUF957 domain-containing protein | - |
| BS647_RS21095 (3890902) | 3890902..3891393 | - | 492 | WP_000976828.1 | DUF5983 family protein | - |
| BS647_RS21100 (3891390) | 3891390..3891764 | - | 375 | WP_000854917.1 | TA system toxin CbtA family protein | Toxin |
| BS647_RS21105 (3891811) | 3891811..3892185 | - | 375 | WP_001280958.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| BS647_RS21115 (3892348) | 3892348..3892569 | - | 222 | WP_001220314.1 | DUF987 domain-containing protein | - |
| BS647_RS21120 (3892632) | 3892632..3893108 | - | 477 | WP_005011624.1 | RadC family protein | - |
| BS647_RS27455 (3893124) | 3893124..3893597 | - | 474 | WP_005011597.1 | antirestriction protein | - |
| BS647_RS21130 (3893939) | 3893939..3894760 | - | 822 | WP_001234584.1 | DUF932 domain-containing protein | - |
| BS647_RS27465 (3894860) | 3894860..3895033 | - | 174 | WP_000088744.1 | DUF905 family protein | - |
| BS647_RS28555 (3895153) | 3895153..3895416 | - | 264 | WP_000466628.1 | DNA polymerase III subunit gamma/tau | - |
| BS647_RS21145 (3896355) | 3896355..3896771 | - | 417 | WP_000275180.1 | AraC family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | tet(B) / blaOXA-1 / catA1 | csgD / csgE / csgF / csgG | 3882685..3935973 | 53288 | |
| - | flank | IS/Tn | - | - | 3888972..3889976 | 1004 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 14145.22 Da Isoelectric Point: 7.7761
>T74326 WP_000854917.1 NZ_CP020342:c3891764-3891390 [Shigella flexneri 1a]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
Download Length: 375 bp
>T74326 NZ_CP020342:c3891764-3891390 [Shigella flexneri 1a]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGTCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGTCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
Antitoxin
Download Length: 125 a.a. Molecular weight: 13793.62 Da Isoelectric Point: 6.4651
>AT74326 WP_001280958.1 NZ_CP020342:c3892185-3891811 [Shigella flexneri 1a]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLYYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAPATTS
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLYYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAPATTS
Download Length: 375 bp
>AT74326 NZ_CP020342:c3892185-3891811 [Shigella flexneri 1a]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGTATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGTATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q93EZ7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0K4PAV2 |