Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 3374881..3375407 | Replicon | chromosome |
| Accession | NZ_CP020342 | ||
| Organism | Shigella flexneri 1a strain 0439 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | BS647_RS18070 | Protein ID | WP_000323025.1 |
| Coordinates | 3375120..3375407 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | BS647_RS18065 | Protein ID | WP_000534858.1 |
| Coordinates | 3374881..3375120 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BS647_RS18040 (3370529) | 3370529..3370732 | + | 204 | WP_000214712.1 | putative selenium delivery protein YdfZ | - |
| BS647_RS18045 (3370768) | 3370768..3372228 | - | 1461 | WP_000527804.1 | mannitol dehydrogenase family protein | - |
| BS647_RS18050 (3372317) | 3372317..3373336 | - | 1020 | Protein_3259 | MHS family MFS transporter YdfJ | - |
| BS647_RS18055 (3373398) | 3373398..3374554 | + | 1157 | Protein_3260 | IS3 family transposase | - |
| BS647_RS18060 (3374551) | 3374551..3374856 | - | 306 | WP_071818640.1 | hypothetical protein | - |
| BS647_RS18065 (3374881) | 3374881..3375120 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| BS647_RS18070 (3375120) | 3375120..3375407 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| BS647_RS18075 (3375479) | 3375479..3375634 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| BS647_RS18080 (3375852) | 3375852..3376103 | + | 252 | WP_000980987.1 | protein Rem | - |
| BS647_RS18085 (3376170) | 3376170..3376448 | + | 279 | Protein_3266 | hypothetical protein | - |
| BS647_RS18090 (3376450) | 3376450..3377499 | + | 1050 | WP_001265249.1 | DUF968 domain-containing protein | - |
| BS647_RS18095 (3377512) | 3377512..3377868 | + | 357 | WP_000904111.1 | RusA family crossover junction endodeoxyribonuclease | - |
| BS647_RS18100 (3377883) | 3377883..3378704 | + | 822 | WP_000762882.1 | antitermination protein | - |
| BS647_RS27375 (3379625) | 3379625..3379733 | + | 109 | Protein_3270 | DUF3927 family protein | - |
| BS647_RS18125 (3380014) | 3380014..3380349 | - | 336 | WP_000871291.1 | anti-adapter protein IraM | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 3364363..3388677 | 24314 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T74323 WP_000323025.1 NZ_CP020342:3375120-3375407 [Shigella flexneri 1a]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T74323 NZ_CP020342:3375120-3375407 [Shigella flexneri 1a]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT74323 WP_000534858.1 NZ_CP020342:3374881-3375120 [Shigella flexneri 1a]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT74323 NZ_CP020342:3374881-3375120 [Shigella flexneri 1a]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|