Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 1863385..1864186 | Replicon | chromosome |
| Accession | NZ_CP020342 | ||
| Organism | Shigella flexneri 1a strain 0439 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A6A9TTQ3 |
| Locus tag | BS647_RS09890 | Protein ID | WP_025760752.1 |
| Coordinates | 1863385..1863762 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | D3GUT4 |
| Locus tag | BS647_RS09895 | Protein ID | WP_001285620.1 |
| Coordinates | 1863809..1864186 (-) | Length | 126 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BS647_RS09860 (1858598) | 1858598..1859065 | + | 468 | WP_011069513.1 | prepilin peptidase | - |
| BS647_RS09870 (1860734) | 1860734..1860979 | - | 246 | WP_000875412.1 | hypothetical protein | - |
| BS647_RS09875 (1861756) | 1861756..1862598 | - | 843 | WP_001290187.1 | DUF4942 domain-containing protein | - |
| BS647_RS09880 (1862683) | 1862683..1862880 | - | 198 | WP_000772029.1 | DUF957 domain-containing protein | - |
| BS647_RS09885 (1862900) | 1862900..1863388 | - | 489 | WP_000761715.1 | DUF5983 family protein | - |
| BS647_RS09890 (1863385) | 1863385..1863762 | - | 378 | WP_025760752.1 | TA system toxin CbtA family protein | Toxin |
| BS647_RS09895 (1863809) | 1863809..1864186 | - | 378 | WP_001285620.1 | type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA | Antitoxin |
| BS647_RS09900 (1864266) | 1864266..1864487 | - | 222 | WP_000692350.1 | DUF987 domain-containing protein | - |
| BS647_RS09905 (1864574) | 1864574..1865050 | - | 477 | WP_001387238.1 | RadC family protein | - |
| BS647_RS09910 (1865066) | 1865066..1865539 | - | 474 | WP_000855059.1 | antirestriction protein | - |
| BS647_RS09920 (1865881) | 1865881..1866699 | - | 819 | WP_001177758.1 | DUF932 domain-containing protein | - |
| BS647_RS28315 (1866878) | 1866878..1866967 | - | 90 | WP_112031555.1 | DUF905 family protein | - |
| BS647_RS09935 (1867110) | 1867110..1867565 | - | 456 | WP_005051844.1 | IrmA family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 13961.79 Da Isoelectric Point: 6.8608
>T74311 WP_025760752.1 NZ_CP020342:c1863762-1863385 [Shigella flexneri 1a]
MNTLPDTHVREASGCSSPITIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPEAKQ
MNTLPDTHVREASGCSSPITIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPEAKQ
Download Length: 378 bp
>T74311 NZ_CP020342:c1863762-1863385 [Shigella flexneri 1a]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCTCGTCTCCCATCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGAATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
TAACTACAGAACGGTAAATAACATTACCCGGGGGAAGCATCCGGAAGCGAAACAATGA
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCTCGTCTCCCATCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGAATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
TAACTACAGAACGGTAAATAACATTACCCGGGGGAAGCATCCGGAAGCGAAACAATGA
Antitoxin
Download Length: 126 a.a. Molecular weight: 13698.52 Da Isoelectric Point: 5.9505
>AT74311 WP_001285620.1 NZ_CP020342:c1864186-1863809 [Shigella flexneri 1a]
VSDTLPGTTPPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDVDAYHLDQAFPLLMKQLELMLTGG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPATTV
VSDTLPGTTPPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDVDAYHLDQAFPLLMKQLELMLTGG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPATTV
Download Length: 378 bp
>AT74311 NZ_CP020342:c1864186-1863809 [Shigella flexneri 1a]
GTGTCAGACACACTCCCCGGGACAACGCCTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCCCGACTGGTACAGGAGGGTAACCGCCTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCAGGT
TCAGCGACGTAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACTGGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCGCCCGCAACCACCGTATAA
GTGTCAGACACACTCCCCGGGACAACGCCTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCCCGACTGGTACAGGAGGGTAACCGCCTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCAGGT
TCAGCGACGTAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACTGGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCGCCCGCAACCACCGTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6A9TTQ3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| PDB | 2INW | |
| AlphaFold DB | A0A0E0Y522 |