Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 911355..911881 | Replicon | chromosome |
| Accession | NZ_CP020339 | ||
| Organism | Shigella flexneri 4c strain 0702 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | BS653_RS05200 | Protein ID | WP_000323025.1 |
| Coordinates | 911355..911642 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | BS653_RS05205 | Protein ID | WP_000534858.1 |
| Coordinates | 911642..911881 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BS653_RS05145 (906413) | 906413..906748 | + | 336 | WP_000871291.1 | anti-adapter protein IraM | - |
| BS653_RS26160 (907029) | 907029..907137 | - | 109 | Protein_948 | DUF3927 family protein | - |
| BS653_RS05170 (908058) | 908058..908879 | - | 822 | WP_000762882.1 | antitermination protein | - |
| BS653_RS05175 (908894) | 908894..909250 | - | 357 | WP_000904111.1 | RusA family crossover junction endodeoxyribonuclease | - |
| BS653_RS05180 (909263) | 909263..910312 | - | 1050 | WP_001265249.1 | DUF968 domain-containing protein | - |
| BS653_RS05185 (910314) | 910314..910592 | - | 279 | Protein_952 | hypothetical protein | - |
| BS653_RS05190 (910659) | 910659..910910 | - | 252 | WP_000980987.1 | protein Rem | - |
| BS653_RS05195 (911128) | 911128..911283 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| BS653_RS05200 (911355) | 911355..911642 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| BS653_RS05205 (911642) | 911642..911881 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| BS653_RS05210 (911906) | 911906..912211 | + | 306 | WP_071818640.1 | hypothetical protein | - |
| BS653_RS05215 (912208) | 912208..913364 | - | 1157 | Protein_958 | IS3 family transposase | - |
| BS653_RS05220 (913426) | 913426..914445 | + | 1020 | Protein_959 | MHS family MFS transporter YdfJ | - |
| BS653_RS05225 (914534) | 914534..915994 | + | 1461 | WP_000527804.1 | mannitol dehydrogenase family protein | - |
| BS653_RS05230 (916030) | 916030..916233 | - | 204 | WP_000214712.1 | putative selenium delivery protein YdfZ | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 895327..914445 | 19118 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T74289 WP_000323025.1 NZ_CP020339:c911642-911355 [Shigella flexneri 4c]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T74289 NZ_CP020339:c911642-911355 [Shigella flexneri 4c]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT74289 WP_000534858.1 NZ_CP020339:c911881-911642 [Shigella flexneri 4c]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT74289 NZ_CP020339:c911881-911642 [Shigella flexneri 4c]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|