Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4534036..4535589 Replicon chromosome
Accession NZ_CP020335
Organism Photorhabdus akhurstii strain 0813-124 phase II

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag B0X70_RS19420 Protein ID WP_217470156.1
Coordinates 4534036..4535334 (-) Length 433 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag B0X70_RS19425 Protein ID WP_036778377.1
Coordinates 4535338..4535589 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B0X70_RS19395 (B0X70_19595) 4529233..4529724 - 492 WP_217470153.1 DUF4225 domain-containing protein -
B0X70_RS19400 (B0X70_19600) 4529730..4530137 - 408 WP_217470154.1 hypothetical protein -
B0X70_RS19405 (B0X70_19605) 4530164..4530583 - 420 WP_246593542.1 Hcp family type VI secretion system effector -
B0X70_RS19410 (B0X70_19610) 4531062..4532576 - 1515 WP_217470155.1 MFS transporter -
B0X70_RS19415 (B0X70_19615) 4532626..4533231 - 606 WP_036808733.1 DUF1062 domain-containing protein -
B0X70_RS19420 (B0X70_19620) 4534036..4535334 - 1299 WP_217470156.1 type II toxin-antitoxin system HipA family toxin Toxin
B0X70_RS19425 (B0X70_19625) 4535338..4535589 - 252 WP_036778377.1 helix-turn-helix domain-containing protein Antitoxin
B0X70_RS19430 (B0X70_19630) 4535786..4536565 - 780 WP_217470157.1 ribonuclease -
B0X70_RS19435 (B0X70_19635) 4536653..4538608 - 1956 WP_217470158.1 bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-64)


Sequences

Toxin        


Download         Length: 433 a.a.        Molecular weight: 48147.37 Da        Isoelectric Point: 6.6955

>T74254 WP_217470156.1 NZ_CP020335:c4535334-4534036 [Photorhabdus akhurstii]
MKALTVALNGFEVGTLFRDGTGAMSFQYKDEWLLLNGARAISLSIPLSTQRHRGKEVFNFFDNLLPDSDAVIARIQARFK
VQSKHPFDLLASVGRDCVGAIQLYPEGADIPPVSDMVGEPLNDDAIIELLEGYQSFPLGMTERDDFRISLAGAQEKTALL
WHQECWQRPQGSTPTSHIFKLPIGRIEQNNIDLRESCENEWLCLKIAKAFGLPVANAELATFGKLKVLIVERFDRRWSSD
GNWLMRLPQEDLCQALGIAPALKYESDGGPGIADAMKLLLGSLQPTQDRETFFKSQILFWLLAAIDGHGKNFSMFIQPES
AYKMTPLYDVLSAYPIFATKGIAPKKAKMAMALRGKNSQYNWAYIQPRHFLSTAQHVGFSTETAESLMTRMGEMSGAVID
QVARELPKDFPSHISGPIFEGLDKQAKKLRVG

Download         Length: 1299 bp

>T74254 NZ_CP020335:c4535334-4534036 [Photorhabdus akhurstii]
ATGAAGGCGTTGACGGTTGCGCTTAATGGTTTTGAGGTCGGAACGCTATTTCGTGATGGCACTGGTGCGATGTCATTTCA
GTACAAAGATGAGTGGTTGCTCCTGAATGGCGCTCGTGCCATTTCACTTTCAATCCCTCTTAGCACCCAACGGCATAGAG
GCAAAGAGGTATTTAATTTCTTCGATAACTTATTACCAGATTCTGATGCGGTTATTGCCAGGATACAGGCTCGGTTCAAG
GTACAAAGCAAGCATCCTTTTGATCTATTGGCTAGTGTGGGAAGGGACTGTGTAGGGGCCATTCAGCTTTATCCAGAAGG
AGCGGACATCCCTCCCGTCAGTGATATGGTTGGTGAACCGCTTAATGATGATGCTATTATCGAGCTGCTAGAAGGGTATC
AAAGCTTCCCGTTGGGAATGACAGAGCGAGATGATTTCAGGATCTCATTAGCCGGAGCTCAAGAAAAAACCGCGCTTCTC
TGGCATCAGGAATGCTGGCAACGCCCCCAAGGAAGTACACCCACGAGCCATATCTTCAAACTGCCAATTGGTCGGATAGA
GCAAAACAATATTGATCTCAGAGAAAGCTGTGAAAACGAATGGCTTTGCCTAAAGATTGCTAAGGCATTTGGCCTCCCTG
TAGCTAATGCCGAATTGGCAACCTTCGGAAAGCTGAAAGTATTGATTGTTGAACGTTTCGACCGTCGATGGTCATCTGAT
GGGAATTGGCTAATGCGTCTTCCACAGGAAGACCTTTGCCAGGCTCTAGGTATTGCTCCGGCACTCAAATATGAATCGGA
TGGTGGACCTGGCATTGCAGACGCTATGAAGCTGTTGCTCGGTTCTCTACAACCAACTCAGGACAGAGAAACGTTCTTCA
AGTCTCAGATCCTGTTCTGGCTGTTGGCGGCGATTGATGGTCATGGCAAAAATTTCAGTATGTTCATTCAGCCTGAATCA
GCGTACAAGATGACACCACTTTACGATGTGTTGTCGGCTTACCCTATTTTTGCGACGAAGGGGATAGCACCGAAAAAGGC
CAAGATGGCAATGGCATTACGAGGAAAGAATAGCCAATATAATTGGGCGTATATCCAGCCACGTCATTTTTTATCTACCG
CTCAACACGTTGGATTTTCTACTGAGACAGCAGAAAGTCTGATGACGCGGATGGGAGAAATGTCAGGAGCTGTAATCGAC
CAAGTTGCGCGTGAATTACCTAAAGACTTCCCTAGTCACATTAGCGGTCCAATCTTTGAGGGGCTTGATAAGCAGGCTAA
AAAACTCCGTGTTGGATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9444.87 Da        Isoelectric Point: 10.3418

>AT74254 WP_036778377.1 NZ_CP020335:c4535589-4535338 [Photorhabdus akhurstii]
MKITSPAMLALAMREARKKSKLTQRETADRVGIKQSTVSGFEKYPEGSKMETLFKLLSALELELHVSERGNSQRTSTGWK
EEW

Download         Length: 252 bp

>AT74254 NZ_CP020335:c4535589-4535338 [Photorhabdus akhurstii]
ATGAAGATCACATCACCAGCAATGCTCGCACTCGCAATGAGAGAGGCCCGTAAAAAAAGCAAATTGACTCAGCGGGAAAC
GGCTGATCGGGTCGGTATTAAACAGAGCACTGTATCGGGATTCGAGAAGTATCCAGAGGGCAGTAAGATGGAAACCTTGT
TCAAGTTACTCTCCGCATTGGAACTGGAGCTCCATGTATCAGAGCGCGGGAATTCACAAAGAACGAGCACCGGTTGGAAA
GAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References