Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4471178..4471977 Replicon chromosome
Accession NZ_CP020335
Organism Photorhabdus akhurstii strain 0813-124 phase II

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A022PP75
Locus tag B0X70_RS19175 Protein ID WP_036775081.1
Coordinates 4471453..4471977 (+) Length 175 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID A0A022PSG6
Locus tag B0X70_RS19170 Protein ID WP_036775083.1
Coordinates 4471178..4471456 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B0X70_RS19150 (B0X70_19350) 4467778..4467996 + 219 WP_235200934.1 exodeoxyribonuclease VII small subunit -
B0X70_RS19155 (B0X70_19355) 4468001..4468918 + 918 WP_217470130.1 (2E,6E)-farnesyl diphosphate synthase -
B0X70_RS19160 (B0X70_19360) 4468981..4470846 + 1866 WP_217470131.1 1-deoxy-D-xylulose-5-phosphate synthase -
B0X70_RS19165 4470971..4471108 - 138 WP_160169972.1 hypothetical protein -
B0X70_RS19170 (B0X70_19365) 4471178..4471456 + 279 WP_036775083.1 DUF1778 domain-containing protein Antitoxin
B0X70_RS19175 (B0X70_19370) 4471453..4471977 + 525 WP_036775081.1 acetyltransferase Toxin
B0X70_RS19180 4472341..4472601 + 261 WP_217470132.1 hypothetical protein -
B0X70_RS19185 (B0X70_19380) 4472583..4473074 - 492 WP_040150005.1 phosphatidylglycerophosphatase A -
B0X70_RS19190 (B0X70_19385) 4473067..4474056 - 990 WP_036775077.1 thiamine-phosphate kinase -
B0X70_RS19195 (B0X70_19390) 4474157..4474573 - 417 WP_036775075.1 transcription antitermination factor NusB -
B0X70_RS19200 (B0X70_19395) 4474600..4475070 - 471 WP_105397750.1 6,7-dimethyl-8-ribityllumazine synthase -
B0X70_RS19205 (B0X70_19400) 4475197..4476306 - 1110 WP_181148284.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -
B0X70_RS19210 (B0X70_19405) 4476311..4476760 - 450 WP_036775072.1 transcriptional regulator NrdR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(3-87)


Sequences

Toxin        


Download         Length: 175 a.a.        Molecular weight: 18997.97 Da        Isoelectric Point: 9.3401

>T74253 WP_036775081.1 NZ_CP020335:4471453-4471977 [Photorhabdus akhurstii]
MMLPIWHEEPIGKHHYRGAFDCGDEALNQFLHRHARQSHEKGGAKTYLAVSESNRTVLGYYSLSPASIAYERAPEVIKRG
LARHEVPVFRLGRLAVDLSVQSQGLGGQLLLAAGRRCLLVATQAGGVALLIDAKNERVAEWYTSYGAIPLLDAHLSLLLP
LKTIHAALVTAGKL

Download         Length: 525 bp

>T74253 NZ_CP020335:4471453-4471977 [Photorhabdus akhurstii]
ATGATGCTACCAATCTGGCACGAAGAGCCTATAGGCAAACATCATTATCGCGGTGCTTTTGACTGTGGTGATGAGGCGTT
GAATCAGTTTTTACATCGCCATGCAAGGCAGAGCCATGAGAAAGGTGGGGCAAAAACCTACCTTGCGGTTAGCGAGAGCA
ATCGGACGGTATTGGGTTACTACAGTCTAAGCCCCGCTTCTATTGCTTATGAACGTGCACCGGAAGTGATTAAACGTGGT
CTGGCTCGACATGAAGTGCCAGTATTTCGGCTTGGCCGTCTGGCTGTAGATCTTTCAGTACAGAGTCAAGGACTCGGTGG
CCAGTTGTTGCTAGCTGCTGGTCGGCGCTGTTTATTGGTGGCCACGCAGGCTGGCGGGGTTGCATTGCTAATTGATGCCA
AGAATGAGCGTGTTGCCGAGTGGTACACCAGCTATGGTGCTATTCCGCTATTAGATGCCCATCTATCTTTGCTGTTACCA
TTAAAAACAATACATGCGGCACTAGTCACTGCGGGAAAGCTTTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10347.92 Da        Isoelectric Point: 5.1133

>AT74253 WP_036775083.1 NZ_CP020335:4471178-4471456 [Photorhabdus akhurstii]
MPQIPVETNDRMSLRIASEEKSLLMRAAALQHTNLTEFVLRNVMSAARKIIDENERLELTERDSLHVLDLLDNPPAPNDK
LLAAAFALPKQS

Download         Length: 279 bp

>AT74253 NZ_CP020335:4471178-4471456 [Photorhabdus akhurstii]
ATGCCTCAGATCCCAGTAGAAACTAATGACCGAATGTCGCTACGTATTGCCTCAGAAGAAAAGTCGCTGTTGATGCGTGC
AGCCGCTTTACAACATACCAACTTGACTGAGTTCGTGCTCCGCAATGTGATGTCAGCAGCACGGAAGATTATCGACGAGA
ACGAACGACTGGAGCTGACCGAAAGAGATAGTTTGCATGTTCTGGATCTTTTGGATAACCCACCGGCACCGAATGATAAA
TTGTTGGCCGCAGCATTTGCCTTGCCGAAACAATCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A022PP75

Antitoxin

Source ID Structure
AlphaFold DB A0A022PSG6

References