Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4164380..4165043 Replicon chromosome
Accession NZ_CP020335
Organism Photorhabdus akhurstii strain 0813-124 phase II

Toxin (Protein)


Gene name cptA Uniprot ID A0A2S8Q2L2
Locus tag B0X70_RS17780 Protein ID WP_046394521.1
Coordinates 4164380..4164796 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A022PJY1
Locus tag B0X70_RS17785 Protein ID WP_036777610.1
Coordinates 4164777..4165043 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B0X70_RS17760 (B0X70_17945) 4160356..4162089 - 1734 WP_217469998.1 single-stranded-DNA-specific exonuclease RecJ -
B0X70_RS17765 (B0X70_17950) 4162095..4162796 - 702 WP_105398497.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
B0X70_RS17770 (B0X70_17955) 4162820..4163731 - 912 WP_051560698.1 site-specific tyrosine recombinase XerD -
B0X70_RS17775 (B0X70_17960) 4163839..4164357 + 519 WP_217469999.1 flavodoxin FldB -
B0X70_RS17780 (B0X70_17965) 4164380..4164796 - 417 WP_046394521.1 protein YgfX Toxin
B0X70_RS17785 (B0X70_17970) 4164777..4165043 - 267 WP_036777610.1 FAD assembly factor SdhE Antitoxin
B0X70_RS17790 (B0X70_17975) 4165221..4166213 + 993 WP_046394520.1 tRNA-modifying protein YgfZ -
B0X70_RS17795 (B0X70_17980) 4166224..4166829 + 606 WP_046394519.1 HD domain-containing protein -
B0X70_RS17800 (B0X70_17985) 4167229..4168545 - 1317 WP_217470000.1 collagen-like protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-135)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 16459.48 Da        Isoelectric Point: 10.5839

>T74252 WP_046394521.1 NZ_CP020335:c4164796-4164380 [Photorhabdus akhurstii]
VVLWRCDLRVSWHTQLISTCVHGVIALIVLLAPWPADNAVFWIFWLPLVLLIIASWGRSQKNIRKSQGLLVLFSDNKLQW
KKHEWRIIRRPWLCRYGILITAQSFYNQKKIRLWVASDGMSQDEWRHINQLLLQYPDI

Download         Length: 417 bp

>T74252 NZ_CP020335:c4164796-4164380 [Photorhabdus akhurstii]
GTGGTCCTGTGGAGGTGTGATCTCAGGGTATCTTGGCATACCCAGTTAATTTCCACCTGTGTTCATGGTGTAATCGCGCT
TATAGTGCTACTTGCTCCGTGGCCTGCGGATAACGCTGTTTTCTGGATTTTCTGGCTTCCTTTGGTACTGTTGATTATTG
CCAGTTGGGGGCGTAGCCAGAAAAATATCCGTAAATCACAAGGGCTTTTAGTTCTGTTCAGTGATAATAAGTTGCAATGG
AAGAAGCACGAGTGGCGAATTATCCGGCGCCCGTGGTTATGTCGCTATGGCATATTAATTACGGCTCAATCTTTTTATAA
CCAGAAAAAAATCCGTTTATGGGTCGCATCCGATGGTATGTCACAGGATGAATGGAGGCATATTAATCAACTGTTGTTGC
AATATCCTGATATCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 4.8890

>AT74252 WP_036777610.1 NZ_CP020335:c4165043-4164777 [Photorhabdus akhurstii]
MDIDNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFIRLLECADPDLFNWLMNHGRPADEELFRMIKLIQNRN
KDRGPVEV

Download         Length: 267 bp

>AT74252 NZ_CP020335:c4165043-4164777 [Photorhabdus akhurstii]
ATGGATATTGATAATAAAGCACGTATTCATTGGGCATGTCGACGTGGAATGCGTGAGCTGGATATTTCAATTATGCCGTT
TTTTGAGTATGAATATGACTCACTCAGTGATGATGATAAACGACTTTTTATTCGCTTGCTTGAATGTGCTGATCCTGATC
TATTTAACTGGTTGATGAATCATGGACGCCCGGCAGATGAAGAGCTATTTCGCATGATTAAACTTATTCAGAATAGAAAT
AAAGATCGTGGTCCTGTGGAGGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S8Q2L2

Antitoxin

Source ID Structure
AlphaFold DB A0A022PJY1

References