Detailed information of TA system TA074247

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-YefM
• Location: 2618682..2619187
• Replicon: chromosome
• Accession: NZ_CP020335
• Organism: Photorhabdus akhurstii strain 0813-124 phase II

Toxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: B0X70_RS11545
• Protein ID: WP_217471536.1
• Coordinates: 2618682..2618936 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relE
• Uniprot ID: A0A1B8YCS9
• Locus tag: B0X70_RS11550
• Protein ID: WP_036806085.1
• Coordinates: 2618933..2619187 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B0X70_RS11525 (B0X70_11645)	2614153..2615337	-	1185	WP_217471534.1	DNA-binding transcriptional regulator	-
B0X70_RS11530 (B0X70_11650)	2615659..2616978	+	1320	WP_217471535.1	xylose isomerase	-
B0X70_RS11535 (B0X70_11655)	2617408..2617956	+	549	WP_235319357.1	hypothetical protein	-
B0X70_RS11540 (B0X70_11665)	2618177..2618551	+	375	WP_040150820.1	VOC family protein	-
B0X70_RS11545 (B0X70_11670)	2618682..2618936	-	255	WP_217471536.1	Txe/YoeB family addiction module toxin	Toxin
B0X70_RS11550 (B0X70_11675)	2618933..2619187	-	255	WP_036806085.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
B0X70_RS11555 (B0X70_11680)	2619358..2619651	+	294	WP_036806082.1	hypothetical protein	-
B0X70_RS11560 (B0X70_11685)	2619782..2620195	-	414	WP_052105690.1	Exc2 family lipoprotein	-
B0X70_RS11565 (B0X70_11690)	2620443..2620682	+	240	WP_040150771.1	type II toxin-antitoxin system CcdA family antitoxin	-
B0X70_RS11570 (B0X70_11695)	2620684..2620776	+	93	Protein_2237	CcdB family protein	-
B0X70_RS11575 (B0X70_11700)	2620778..2620966	-	189	WP_036806074.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10343.88 Da
• Isoelectric Point: 9.3466

>T74247 WP_217471536.1 NZ_CP020335:c2618936-2618682 [Photorhabdus akhurstii]
MILSWAEMAWEDYLYWQQTDKKVLKRVNTLIKDIKRQSFDGLGDPEPLKHNWSGYWSRRINREHRLIYKVTDDAIIIVQC
RYHY

Nucleotide

• Length: 255 bp

>T74247 NZ_CP020335:c2618936-2618682 [Photorhabdus akhurstii]
ATGATTTTATCTTGGGCTGAAATGGCATGGGAGGACTATCTGTATTGGCAACAAACCGATAAAAAAGTCCTAAAGCGTGT
TAATACACTCATCAAAGACATTAAAAGGCAATCCTTCGATGGATTAGGGGATCCGGAGCCTTTAAAACATAATTGGTCAG
GTTATTGGTCTAGACGTATTAATCGAGAGCATCGTCTGATTTACAAGGTAACAGATGATGCAATCATTATCGTACAATGT
CGCTATCACTATTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9333.56 Da
• Isoelectric Point: 4.7769

>AT74247 WP_036806085.1 NZ_CP020335:c2619187-2618933 [Photorhabdus akhurstii]
MDTISYSAFRTHLASTLDRVNDDHKPILITRQNGKPAVVLSLEDFQAYEETAYLMASPKNAARLSQAIAEVEAGRIIEKG
LLEE

Nucleotide

• Length: 255 bp

>AT74247 NZ_CP020335:c2619187-2618933 [Photorhabdus akhurstii]
ATGGACACAATAAGCTATTCAGCATTTAGAACTCACTTGGCCAGCACTTTAGATAGAGTGAACGACGATCACAAGCCAAT
TTTAATTACTCGCCAGAATGGCAAGCCAGCGGTTGTCCTAAGTTTGGAAGATTTTCAAGCCTACGAAGAAACAGCCTATT
TAATGGCTAGCCCGAAAAATGCTGCACGTTTAAGTCAGGCAATTGCTGAAGTGGAAGCAGGAAGAATAATTGAAAAAGGG
CTATTAGAAGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A1B8YCS9