Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 1552230..1552761 Replicon chromosome
Accession NZ_CP020335
Organism Photorhabdus akhurstii strain 0813-124 phase II

Toxin (Protein)


Gene name relE Uniprot ID A0A329VBX0
Locus tag B0X70_RS06690 Protein ID WP_036813362.1
Coordinates 1552480..1552761 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q7N738
Locus tag B0X70_RS06685 Protein ID WP_011145648.1
Coordinates 1552230..1552493 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B0X70_RS06675 (B0X70_06770) 1548159..1548608 + 450 WP_217471169.1 cupin domain-containing protein -
B0X70_RS06680 (B0X70_06775) 1549332..1552007 + 2676 WP_217471170.1 beta-N-acetylhexosaminidase -
B0X70_RS06685 (B0X70_06780) 1552230..1552493 + 264 WP_011145648.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
B0X70_RS06690 (B0X70_06785) 1552480..1552761 + 282 WP_036813362.1 type II toxin-antitoxin system YafQ family toxin Toxin
B0X70_RS06695 (B0X70_06790) 1552865..1553311 - 447 WP_036776678.1 ferric iron uptake transcriptional regulator -
B0X70_RS06700 (B0X70_06795) 1553677..1554207 - 531 WP_036776677.1 flavodoxin FldA -
B0X70_RS06705 (B0X70_06800) 1554382..1554669 - 288 WP_110090925.1 LexA regulated protein -
B0X70_RS06710 (B0X70_06805) 1554808..1555776 - 969 WP_217471171.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-72)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10861.53 Da        Isoelectric Point: 6.4735

>T74239 WP_036813362.1 NZ_CP020335:1552480-1552761 [Photorhabdus akhurstii]
MRTIDYASQFKRDYKREKKGRHREVLDDVLMLVIELLASDSLLEPKYCDHALSGDWKDFRDCHIKPDLILIYQKPDADTL
CLVRLGSHSELGL

Download         Length: 282 bp

>T74239 NZ_CP020335:1552480-1552761 [Photorhabdus akhurstii]
ATGCGGACGATTGACTACGCAAGCCAATTTAAGCGAGATTACAAGAGAGAAAAGAAAGGTCGGCATCGTGAAGTTCTTGA
TGACGTACTGATGCTGGTGATTGAATTATTGGCTTCTGATAGTTTGCTAGAGCCGAAATATTGCGATCATGCTCTTTCTG
GTGATTGGAAGGATTTTCGAGATTGTCATATCAAGCCTGACTTGATACTGATTTATCAGAAACCCGATGCGGACACATTG
TGCCTTGTCCGTCTTGGCTCTCACTCAGAGCTTGGCTTATAG

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9367.91 Da        Isoelectric Point: 5.0649

>AT74239 WP_011145648.1 NZ_CP020335:1552230-1552493 [Photorhabdus akhurstii]
MATNQLVQTRIDGEIKTEAAAVLAAMGLTVSDAVRMMLTRVAREKVLPFEPLVPNETTIAAMKEARKGCGKSFSTVKDLM
ADLNADD

Download         Length: 264 bp

>AT74239 NZ_CP020335:1552230-1552493 [Photorhabdus akhurstii]
ATGGCTACAAACCAATTAGTACAAACCCGTATAGATGGAGAGATTAAGACAGAGGCGGCTGCCGTTCTGGCTGCTATGGG
TTTGACTGTATCAGATGCCGTTCGCATGATGTTAACGCGGGTAGCAAGAGAAAAAGTGTTACCTTTTGAGCCGTTGGTAC
CAAATGAGACAACAATAGCTGCAATGAAAGAAGCTCGCAAAGGTTGCGGTAAATCATTTTCCACTGTAAAAGATTTAATG
GCCGATCTTAATGCGGACGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A329VBX0

Antitoxin

Source ID Structure
AlphaFold DB A0A6L9JP47

References