74238

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 1422117..1422816 Replicon chromosome
Accession NZ_CP020335
Organism Photorhabdus akhurstii strain 0813-124 phase II

Toxin (Protein)


Gene name tad Uniprot ID Q7N7C8
Locus tag B0X70_RS06100 Protein ID WP_011145550.1
Coordinates 1422436..1422816 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID Q7N7C9
Locus tag B0X70_RS06095 Protein ID WP_011145549.1
Coordinates 1422117..1422455 (-) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B0X70_RS06085 (B0X70_06180) 1418109..1421291 + 3183 WP_217471133.1 non-ribosomal peptide synthetase -
B0X70_RS06090 (B0X70_06185) 1421544..1421810 + 267 WP_246593454.1 aminotransferase class III-fold pyridoxal phosphate-dependent enzyme -
B0X70_RS06095 (B0X70_06190) 1422117..1422455 - 339 WP_011145549.1 helix-turn-helix transcriptional regulator Antitoxin
B0X70_RS06100 (B0X70_06195) 1422436..1422816 - 381 WP_011145550.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
B0X70_RS06105 (B0X70_06200) 1423133..1424470 - 1338 WP_217471134.1 MSMEG_0569 family flavin-dependent oxidoreductase -
B0X70_RS06110 (B0X70_06205) 1424483..1424773 - 291 WP_036814154.1 MSMEG_0570 family nitrogen starvation response protein -
B0X70_RS06115 (B0X70_06210) 1424761..1425816 - 1056 WP_217471135.1 sll0787 family AIR synthase-like protein -
B0X70_RS06120 (B0X70_06215) 1425813..1426373 - 561 WP_217471136.1 GNAT family N-acetyltransferase -
B0X70_RS06125 (B0X70_06220) 1426386..1427483 - 1098 WP_217471137.1 MSMEG_0568 family radical SAM protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(17-110)

Antitoxin

HigA2-like, helix-turn-helix domain

(18-97)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14281.46 Da        Isoelectric Point: 8.5211

>T74238 WP_011145550.1 NZ_CP020335:c1422816-1422436 [Photorhabdus akhurstii]
MEQQSEKLLVWIGSSKKDLLNLPKDVQRFFGFALDFAQRGEKHDAVKVMKGFGGAGVLEVLEDDIGGTYRAVYTVKFDEA
VFVLHAFQKKSKHGIATPKEDMDIIRNRLKVAAVMAQEMKNERENH

Download         Length: 381 bp

>T74238 NZ_CP020335:c1422816-1422436 [Photorhabdus akhurstii]
ATGGAGCAACAAAGTGAAAAGCTGCTAGTGTGGATAGGCAGCAGCAAGAAGGACTTGCTGAACTTGCCGAAGGACGTGCA
GCGCTTCTTTGGCTTTGCCCTAGACTTCGCGCAGCGTGGCGAAAAGCATGATGCTGTGAAGGTGATGAAAGGGTTTGGTG
GTGCCGGCGTTCTGGAAGTGTTGGAGGACGACATAGGTGGTACCTACCGAGCGGTGTATACGGTGAAATTTGACGAAGCG
GTCTTTGTGCTACATGCCTTTCAGAAGAAGAGTAAGCACGGCATAGCGACGCCGAAAGAAGATATGGACATCATCCGTAA
TCGACTGAAAGTGGCCGCTGTGATGGCCCAGGAGATGAAAAATGAAAGAGAAAACCATTAA

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 12213.14 Da        Isoelectric Point: 9.8793

>AT74238 WP_011145549.1 NZ_CP020335:c1422455-1422117 [Photorhabdus akhurstii]
MKEKTINGVAVEISSGNVFADLGFRDAEKHKIKSGLAFEIIKSIKRLGLTQTTAGERIGISQAKVSHLFRGDFSNLSERK
MMECLNRLGCDIEITVKPTTAQTGHLILAHSG

Download         Length: 339 bp

>AT74238 NZ_CP020335:c1422455-1422117 [Photorhabdus akhurstii]
ATGAAAGAGAAAACCATTAATGGCGTAGCAGTTGAAATCAGCTCCGGCAACGTGTTTGCCGATCTGGGTTTCCGTGATGC
CGAAAAGCACAAAATTAAATCCGGCTTGGCCTTTGAGATCATCAAATCTATCAAGCGTCTGGGGCTGACACAAACTACTG
CTGGCGAACGTATTGGGATCAGCCAGGCAAAAGTATCCCACCTGTTCCGGGGCGATTTTTCCAACCTGTCAGAACGTAAG
ATGATGGAGTGTCTGAATCGGCTGGGGTGTGACATCGAGATCACTGTCAAGCCGACTACTGCCCAAACCGGGCATTTAAT
TTTGGCACATAGCGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L9JUM5

Antitoxin

Source ID Structure
AlphaFold DB A0A6L9JSP2

References