Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1108679..1109334 Replicon chromosome
Accession NZ_CP020335
Organism Photorhabdus akhurstii strain 0813-124 phase II

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag B0X70_RS04795 Protein ID WP_217471006.1
Coordinates 1108936..1109334 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag B0X70_RS04790 Protein ID WP_112896116.1
Coordinates 1108679..1108939 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B0X70_RS04780 (B0X70_04840) 1108134..1108418 - 285 WP_214040179.1 helix-turn-helix transcriptional regulator -
B0X70_RS04785 (B0X70_04845) 1108408..1108632 - 225 WP_217471005.1 type II toxin-antitoxin system RelE/ParE family toxin -
B0X70_RS04790 (B0X70_04850) 1108679..1108939 + 261 WP_112896116.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
B0X70_RS04795 (B0X70_04855) 1108936..1109334 + 399 WP_217471006.1 type II toxin-antitoxin system VapC family toxin Toxin
B0X70_RS04800 (B0X70_04860) 1109410..1110693 - 1284 WP_217471007.1 glutamate-1-semialdehyde 2,1-aminomutase -
B0X70_RS04805 (B0X70_04865) 1110744..1111529 - 786 WP_217471008.1 DUF1460 domain-containing protein -
B0X70_RS04810 (B0X70_04870) 1111848..1112192 + 345 WP_036781943.1 iron-sulfur cluster insertion protein ErpA -
B0X70_RS04815 (B0X70_04875) 1112274..1113101 - 828 WP_246593431.1 vitamin B12 ABC transporter substrate-binding protein BtuF -
B0X70_RS04820 (B0X70_04880) 1113182..1113883 - 702 WP_036781932.1 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(8-55)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15068.77 Da        Isoelectric Point: 7.5174

>T74236 WP_217471006.1 NZ_CP020335:1108936-1109334 [Photorhabdus akhurstii]
MKHYMLDTNVVGHFIRGHYSVVQHVLSVPMSSLCISAITEGELLFGLARRPEAKRLRIAVREFLMRIDVLPWDDSVAEHY
GMIKAEMQKQGKILAPLDLLIAAHSLNMKMILVTNDRAFQYVPGLHIEDWTV

Download         Length: 399 bp

>T74236 NZ_CP020335:1108936-1109334 [Photorhabdus akhurstii]
ATGAAGCATTATATGCTTGATACAAATGTAGTAGGGCATTTTATCAGAGGGCACTATTCAGTCGTGCAGCATGTTCTGTC
TGTGCCAATGTCGTCACTTTGTATTTCAGCTATTACAGAAGGTGAATTATTGTTTGGGTTGGCGCGTCGCCCAGAAGCAA
AGCGACTCCGTATAGCAGTAAGAGAGTTTCTCATGCGTATTGATGTTTTACCTTGGGATGATTCTGTTGCTGAACACTAT
GGTATGATCAAGGCTGAGATGCAAAAACAGGGTAAGATATTAGCACCACTTGATTTACTTATTGCAGCACACTCGCTAAA
TATGAAGATGATATTGGTTACAAATGATCGTGCTTTTCAATATGTACCGGGATTGCATATCGAAGATTGGACTGTTTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9920.00 Da        Isoelectric Point: 4.6533

>AT74236 WP_112896116.1 NZ_CP020335:1108679-1108939 [Photorhabdus akhurstii]
MGHIAKLFMNGRSQAVRLPAAYRFDSDEVFIRKDPETGDVILSRKPHNWDGFFAALKGTAIPDDFLSEGERYQQEQSRDP
FEGWEE

Download         Length: 261 bp

>AT74236 NZ_CP020335:1108679-1108939 [Photorhabdus akhurstii]
ATGGGGCATATAGCTAAATTGTTTATGAATGGGAGGAGTCAAGCGGTACGTCTGCCAGCGGCTTATCGATTTGATTCTGA
TGAAGTTTTTATCCGAAAGGATCCTGAGACAGGAGATGTAATACTGTCCCGTAAGCCACACAACTGGGATGGATTTTTTG
CGGCATTGAAGGGAACAGCTATCCCCGATGATTTTCTGAGTGAAGGAGAACGGTACCAGCAAGAGCAATCTCGTGATCCG
TTCGAGGGATGGGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References