Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 277511..278135 Replicon chromosome
Accession NZ_CP020335
Organism Photorhabdus akhurstii strain 0813-124 phase II

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag B0X70_RS01205 Protein ID WP_217470695.1
Coordinates 277511..277666 (+) Length 52 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag B0X70_RS01210 Protein ID WP_217470696.1
Coordinates 277698..278135 (+) Length 146 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B0X70_RS01180 (B0X70_01190) 273248..273739 + 492 WP_217470693.1 CaiF/GrlA family transcriptional regulator -
B0X70_RS01185 (B0X70_01195) 273839..274225 + 387 WP_217470694.1 hypothetical protein -
B0X70_RS01190 (B0X70_01200) 274264..276381 - 2118 WP_036813825.1 bifunctional GTP diphosphokinase/guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase -
B0X70_RS01195 (B0X70_01205) 276399..276674 - 276 WP_011144672.1 DNA-directed RNA polymerase subunit omega -
B0X70_RS01200 (B0X70_01210) 276729..277352 - 624 WP_046395304.1 guanylate kinase -
B0X70_RS01205 (B0X70_01215) 277511..277666 + 156 WP_217470695.1 type II toxin-antitoxin system HicA family toxin Toxin
B0X70_RS01210 (B0X70_01220) 277698..278135 + 438 WP_217470696.1 hypothetical protein Antitoxin
B0X70_RS01215 (B0X70_01225) 278376..279161 - 786 WP_246593406.1 hypothetical protein -
B0X70_RS24945 280088..280480 - 393 WP_246593407.1 hypothetical protein -
B0X70_RS01225 280686..281084 + 399 WP_217471811.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(10-51)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-82)


Sequences

Toxin        


Download         Length: 52 a.a.        Molecular weight: 5483.38 Da        Isoelectric Point: 10.9062

>T74231 WP_217470695.1 NZ_CP020335:277511-277666 [Photorhabdus akhurstii]
VTSQGVLIEKARGGGSHRKVSINGKSSVFPDHGSKEIPEPLRKKIMKDLGL

Download         Length: 156 bp

>T74231 NZ_CP020335:277511-277666 [Photorhabdus akhurstii]
GTGACTTCTCAAGGAGTGCTGATAGAAAAGGCTAGGGGTGGAGGAAGCCACCGAAAGGTATCTATAAATGGTAAATCGTC
GGTTTTCCCCGATCATGGCTCCAAAGAGATCCCTGAACCATTGAGGAAGAAAATAATGAAGGATCTGGGGCTTTAA

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 16000.40 Da        Isoelectric Point: 4.9914

>AT74231 WP_217470696.1 NZ_CP020335:277698-278135 [Photorhabdus akhurstii]
MFNYPIKLEYDEATGSYVASCRDLPLFNSVGDSVDEALLESIDGLVTAIAIEIDKRRPIPEASLLEAGEYVVSLPILVAM
KAALHNAMIETGTRKVDLARRLGQKGPQIDRLLDVEHSSKVEVVELALHQLNRKLDIAVNTTLHH

Download         Length: 438 bp

>AT74231 NZ_CP020335:277698-278135 [Photorhabdus akhurstii]
ATGTTTAATTATCCGATAAAACTAGAATATGACGAAGCGACAGGAAGTTATGTGGCTAGTTGTCGTGATCTTCCCTTATT
CAACTCAGTAGGTGACTCAGTTGATGAAGCTCTTCTCGAATCTATTGATGGGTTGGTTACGGCTATTGCTATAGAAATTG
ACAAACGTCGGCCTATACCTGAAGCATCCCTGTTGGAGGCAGGTGAATATGTTGTCAGTCTCCCTATTCTGGTCGCAATG
AAAGCGGCATTGCATAATGCAATGATAGAGACAGGAACACGCAAAGTCGATCTTGCTCGACGATTAGGGCAAAAGGGGCC
ACAGATTGATCGGCTTCTTGATGTTGAACATTCATCAAAGGTTGAAGTTGTTGAATTGGCCTTGCATCAGTTAAATAGAA
AGTTAGATATAGCGGTTAATACTACATTACATCATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References