Detailed information of TA system TA074227

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 2846360..2846916
• Replicon: chromosome
• Accession: NZ_CP020334
• Organism: Xanthomonas oryzae pv. oryzae strain XM9

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: B4599_RS14115
• Protein ID: WP_027703932.1
• Coordinates: 2846360..2846650 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A854CIX2
• Locus tag: B4599_RS14120
• Protein ID: WP_011408759.1
• Coordinates: 2846638..2846916 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B4599_RS14065	2842130..2843221	+	1092	WP_041182166.1	ribonuclease D	-
B4599_RS14070	2843297..2843634	-	338	Protein_2535	ATP-dependent DNA ligase	-
B4599_RS24600	2843694..2843900	-	207	Protein_2536	hypothetical protein	-
B4599_RS14080	2843916..2844092	-	177	Protein_2537	DUF3606 domain-containing protein	-
B4599_RS14085	2844314..2844715	+	402	WP_011259345.1	H-NS histone family protein	-
B4599_RS14105	2845579..2845758	-	180	WP_015463309.1	hypothetical protein	-
B4599_RS14110	2846029..2846283	-	255	WP_198912806.1	hypothetical protein	-
B4599_RS14115	2846360..2846650	-	291	WP_027703932.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
B4599_RS14120	2846638..2846916	-	279	WP_011408759.1	CopG family ribbon-helix-helix protein	Antitoxin
B4599_RS24860	2846997..2847200	-	204	WP_199285669.1	hypothetical protein	-
B4599_RS24865	2847112..2847456	-	345	WP_199285675.1	hypothetical protein	-
B4599_RS14130	2847401..2847601	-	201	WP_027703931.1	ribbon-helix-helix protein, CopG family	-
B4599_RS14135	2848362..2849546	-	1185	WP_011408397.1	IS256 family transposase	-
B4599_RS14145	2850127..2851092	+	966	WP_109181928.1	IS1595-like element ISXo5 family transposase	-
B4599_RS14150	2851194..2851799	+	606	Protein_2548	DNA-3-methyladenine glycosylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10915.48 Da
• Isoelectric Point: 9.5554

>T74227 WP_027703932.1 NZ_CP020334:c2846650-2846360 [Xanthomonas oryzae pv. oryzae]
MPQVIFAPAAIGDMLRLREFLRPKNPDAARRAGEAIRRGVQALGAHPRMGRLIEDLSEQYREWLIDFGDSGYVARYRFDG
DTVTILAVRHQKEAGY

Nucleotide

• Length: 291 bp

>T74227 NZ_CP020334:c2846650-2846360 [Xanthomonas oryzae pv. oryzae]
ATGCCACAAGTAATCTTTGCGCCGGCGGCGATCGGGGACATGCTACGGCTGCGTGAATTCCTGAGGCCGAAGAATCCCGA
TGCCGCGAGGCGGGCCGGCGAAGCGATTAGGCGCGGCGTCCAGGCTCTCGGTGCCCACCCTCGAATGGGGCGGCTCATAG
AAGATCTGTCTGAACAGTATCGGGAGTGGCTTATCGATTTTGGGGATAGCGGCTATGTGGCTCGGTACCGCTTCGATGGG
GATACCGTCACGATTTTGGCCGTGCGACACCAGAAGGAAGCGGGGTACTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10826.11 Da
• Isoelectric Point: 4.9736

>AT74227 WP_011408759.1 NZ_CP020334:c2846916-2846638 [Xanthomonas oryzae pv. oryzae]
MVTATSIKLDDELKGRVQHLAESRRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Nucleotide

• Length: 279 bp

>AT74227 NZ_CP020334:c2846916-2846638 [Xanthomonas oryzae pv. oryzae]
ATGGTTACGGCAACTTCCATCAAGCTTGATGATGAATTGAAAGGGCGGGTTCAGCACTTGGCAGAGTCGCGCCGGCGTAC
CCCGCATTGGATCATGCGCGAAGCCATTGAGCAGTACGTCGAGCGCGAGGAAAAGCGCGAGGCGCTGAACCGGGACACGC
TCAAGGCATGGGATGAATTTCAGGCGACTGGCCTGCATGTGACCGCTGAGGAAGTGGACAAGTGGCTCGCTAGCTGGGGA
ACTGACGACGAACTGCCTCCGCCAGAATGCCACAAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A854CIX2