Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 254334..255364 | Replicon | plasmid pMM259 |
| Accession | NZ_CP020332 | ||
| Organism | Martelella mediterranea DSM 17316 strain MACL11 | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | - |
| Locus tag | Mame_RS25660 | Protein ID | WP_007803220.1 |
| Coordinates | 254334..254903 (-) | Length | 190 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | V9WPQ5 |
| Locus tag | Mame_RS25665 | Protein ID | WP_007803221.1 |
| Coordinates | 254900..255364 (-) | Length | 155 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| Mame_RS25635 | 249591..250985 | + | 1395 | WP_007803209.1 | membrane protein | - |
| Mame_RS25645 | 251416..252348 | - | 933 | WP_007803217.1 | IS5-like element ISRhba5 family transposase | - |
| Mame_RS25650 | 252542..253195 | + | 654 | WP_026173657.1 | hypothetical protein | - |
| Mame_RS25655 | 253433..254275 | + | 843 | WP_018065890.1 | hypothetical protein | - |
| Mame_RS25660 | 254334..254903 | - | 570 | WP_007803220.1 | PIN domain-containing protein | Toxin |
| Mame_RS25665 | 254900..255364 | - | 465 | WP_007803221.1 | excisionase family DNA-binding protein | Antitoxin |
| Mame_RS25670 | 255514..256581 | - | 1068 | WP_007803223.1 | hypothetical protein | - |
| Mame_RS25675 | 256808..257692 | + | 885 | WP_018065891.1 | recombinase family protein | - |
| Mame_RS25680 | 257771..258166 | - | 396 | WP_018065892.1 | PIN domain-containing protein | - |
| Mame_RS25685 | 258156..258383 | - | 228 | WP_018065893.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..258597 | 258597 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 190 a.a. Molecular weight: 21163.39 Da Isoelectric Point: 5.2804
>T74224 WP_007803220.1 NZ_CP020332:c254903-254334 [Martelella mediterranea DSM 17316]
MSQYTVLFDANVLYPAPMRDALMQLAVTDLFKAKWTADIHREWIDALLRNEPHRERAALERTRDLMDRATRDCLVTGYEA
LVPALTLPDPDDRHVLAAAIVGRCDAIVTQNLKDFPPAALAPFGIETQHPDDFFRNQLSLAPGLVCSALRKVRARLKNPL
KSVDEYLAILTQQGLVATVADLEQFADLL
MSQYTVLFDANVLYPAPMRDALMQLAVTDLFKAKWTADIHREWIDALLRNEPHRERAALERTRDLMDRATRDCLVTGYEA
LVPALTLPDPDDRHVLAAAIVGRCDAIVTQNLKDFPPAALAPFGIETQHPDDFFRNQLSLAPGLVCSALRKVRARLKNPL
KSVDEYLAILTQQGLVATVADLEQFADLL
Download Length: 570 bp
>T74224 NZ_CP020332:c254903-254334 [Martelella mediterranea DSM 17316]
ATGAGCCAGTACACGGTCCTGTTCGATGCGAACGTCCTTTATCCCGCGCCGATGCGCGATGCACTGATGCAGTTGGCGGT
CACAGACCTTTTCAAGGCCAAGTGGACGGCCGATATCCATCGGGAGTGGATTGATGCGCTTCTGCGCAATGAACCTCATC
GGGAGCGCGCCGCGCTGGAACGAACTCGCGACTTGATGGACAGGGCCACACGCGACTGTCTGGTCACCGGCTACGAGGCA
TTGGTGCCGGCCCTAACACTGCCGGACCCTGACGATCGGCACGTTCTGGCGGCGGCAATCGTTGGGCGCTGTGACGCGAT
CGTCACGCAGAACCTGAAGGACTTCCCACCAGCGGCACTTGCGCCCTTTGGCATCGAGACCCAACACCCTGACGACTTTT
TCCGGAACCAACTGTCTCTCGCGCCCGGTCTGGTCTGTTCCGCGCTGCGGAAAGTTCGCGCGCGCCTCAAGAATCCGCTC
AAAAGCGTCGACGAGTATCTCGCGATCCTGACACAGCAGGGGTTGGTCGCCACGGTTGCCGACCTGGAGCAATTCGCCGA
CCTGCTTTGA
ATGAGCCAGTACACGGTCCTGTTCGATGCGAACGTCCTTTATCCCGCGCCGATGCGCGATGCACTGATGCAGTTGGCGGT
CACAGACCTTTTCAAGGCCAAGTGGACGGCCGATATCCATCGGGAGTGGATTGATGCGCTTCTGCGCAATGAACCTCATC
GGGAGCGCGCCGCGCTGGAACGAACTCGCGACTTGATGGACAGGGCCACACGCGACTGTCTGGTCACCGGCTACGAGGCA
TTGGTGCCGGCCCTAACACTGCCGGACCCTGACGATCGGCACGTTCTGGCGGCGGCAATCGTTGGGCGCTGTGACGCGAT
CGTCACGCAGAACCTGAAGGACTTCCCACCAGCGGCACTTGCGCCCTTTGGCATCGAGACCCAACACCCTGACGACTTTT
TCCGGAACCAACTGTCTCTCGCGCCCGGTCTGGTCTGTTCCGCGCTGCGGAAAGTTCGCGCGCGCCTCAAGAATCCGCTC
AAAAGCGTCGACGAGTATCTCGCGATCCTGACACAGCAGGGGTTGGTCGCCACGGTTGCCGACCTGGAGCAATTCGCCGA
CCTGCTTTGA
Antitoxin
Download Length: 155 a.a. Molecular weight: 16891.48 Da Isoelectric Point: 6.4929
>AT74224 WP_007803221.1 NZ_CP020332:c255364-254900 [Martelella mediterranea DSM 17316]
MNMLAHRHLPPTPQDAAIARVSGQALSRFAQARAPLKLRVTDSEQMEPIELPAGAVSLLMEILEAMAAGRGVTIIPENAE
LSTVQAAEVLNVSRPFLIKLLEDGAIPHRKVGKHRRVRMEDVMSYKAAIDTEREAALDQLAADAQEQDMGYRSK
MNMLAHRHLPPTPQDAAIARVSGQALSRFAQARAPLKLRVTDSEQMEPIELPAGAVSLLMEILEAMAAGRGVTIIPENAE
LSTVQAAEVLNVSRPFLIKLLEDGAIPHRKVGKHRRVRMEDVMSYKAAIDTEREAALDQLAADAQEQDMGYRSK
Download Length: 465 bp
>AT74224 NZ_CP020332:c255364-254900 [Martelella mediterranea DSM 17316]
ATGAACATGCTGGCACACCGACATCTTCCGCCCACGCCGCAGGACGCAGCGATTGCGCGCGTCTCTGGCCAGGCATTGTC
ACGCTTCGCCCAGGCGCGCGCGCCGTTGAAACTTCGTGTGACGGACTCCGAGCAGATGGAGCCGATCGAGCTTCCTGCGG
GCGCCGTATCGCTGCTCATGGAGATCCTCGAGGCGATGGCAGCGGGGCGGGGGGTCACCATCATCCCCGAGAACGCCGAA
CTCTCGACCGTACAGGCCGCTGAGGTTCTGAACGTCTCGCGTCCGTTCCTGATCAAGCTGCTCGAGGATGGTGCCATACC
GCATCGGAAGGTCGGCAAGCATCGCCGCGTCCGCATGGAAGACGTGATGTCCTACAAGGCCGCGATCGATACCGAGCGTG
AAGCTGCGCTCGATCAACTGGCCGCCGACGCTCAAGAGCAGGACATGGGCTACCGCTCGAAATGA
ATGAACATGCTGGCACACCGACATCTTCCGCCCACGCCGCAGGACGCAGCGATTGCGCGCGTCTCTGGCCAGGCATTGTC
ACGCTTCGCCCAGGCGCGCGCGCCGTTGAAACTTCGTGTGACGGACTCCGAGCAGATGGAGCCGATCGAGCTTCCTGCGG
GCGCCGTATCGCTGCTCATGGAGATCCTCGAGGCGATGGCAGCGGGGCGGGGGGTCACCATCATCCCCGAGAACGCCGAA
CTCTCGACCGTACAGGCCGCTGAGGTTCTGAACGTCTCGCGTCCGTTCCTGATCAAGCTGCTCGAGGATGGTGCCATACC
GCATCGGAAGGTCGGCAAGCATCGCCGCGTCCGCATGGAAGACGTGATGTCCTACAAGGCCGCGATCGATACCGAGCGTG
AAGCTGCGCTCGATCAACTGGCCGCCGACGCTCAAGAGCAGGACATGGGCTACCGCTCGAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|