Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1087790..1088448 Replicon chromosome
Accession NZ_CP020330
Organism Martelella mediterranea DSM 17316 strain MACL11

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag Mame_RS04975 Protein ID WP_018064850.1
Coordinates 1088047..1088448 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag Mame_RS04970 Protein ID WP_210162248.1
Coordinates 1087790..1088044 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Mame_RS04965 1082995..1087719 + 4725 WP_018064852.1 glutamate synthase large subunit -
Mame_RS04970 1087790..1088044 + 255 WP_210162248.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
Mame_RS04975 1088047..1088448 + 402 WP_018064850.1 type II toxin-antitoxin system VapC family toxin Toxin
Mame_RS04980 1088494..1088817 + 324 WP_018064849.1 heavy metal-binding domain-containing protein -
Mame_RS04985 1088831..1090285 + 1455 WP_026173483.1 glutamate synthase subunit beta -
Mame_RS04990 1090441..1091328 + 888 WP_018064847.1 UTP--glucose-1-phosphate uridylyltransferase GalU -
Mame_RS04995 1091393..1092385 + 993 WP_018064846.1 KpsF/GutQ family sugar-phosphate isomerase -
Mame_RS05000 1092401..1092904 - 504 WP_018064845.1 disulfide bond formation protein B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-123)

Antitoxin

SpoVT-AbrB domain

(10-48)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14882.13 Da        Isoelectric Point: 4.8122

>T74220 WP_018064850.1 NZ_CP020330:1088047-1088448 [Martelella mediterranea DSM 17316]
MKYLLDTNAISHALKFPAGPVGRRLFEEDADALCTSIVVVAELRFGYMRRGSERLKRDVETLVGSLDILPWESPAEWKYA
ELRLALERAGTPIGQMDMLIAAHALALDAVVVTANEREFAQVPGLKVENWERD

Download         Length: 402 bp

>T74220 NZ_CP020330:1088047-1088448 [Martelella mediterranea DSM 17316]
ATGAAGTATCTGCTGGATACAAATGCGATATCGCATGCGCTGAAATTTCCGGCCGGACCGGTCGGCCGGAGATTGTTCGA
GGAAGATGCCGACGCGCTGTGCACCAGTATCGTCGTGGTGGCCGAGCTTCGGTTCGGTTATATGAGACGGGGCTCCGAGC
GGCTCAAAAGGGATGTCGAGACGCTGGTTGGCAGTCTGGATATCCTGCCGTGGGAAAGCCCGGCAGAGTGGAAATATGCC
GAACTGCGACTGGCGCTGGAAAGGGCCGGCACGCCGATCGGCCAGATGGACATGCTGATCGCCGCCCACGCGCTTGCGCT
CGATGCGGTGGTGGTGACGGCGAACGAGAGAGAATTTGCGCAGGTTCCCGGCCTCAAGGTCGAGAACTGGGAACGTGATT
AG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9893.35 Da        Isoelectric Point: 4.4348

>AT74220 WP_210162248.1 NZ_CP020330:1087790-1088044 [Martelella mediterranea DSM 17316]
ITKERKSRIFMNGRSRAVRIPSEFELEGDEVIIRQEESGLITIEPVKKKMTPREVIEWLRAEPPLPEDEWLPEIEDLPPR
DVDL

Download         Length: 255 bp

>AT74220 NZ_CP020330:1087790-1088044 [Martelella mediterranea DSM 17316]
ATCACCAAGGAAAGAAAGTCCCGCATTTTCATGAATGGCCGCAGCCGCGCCGTGCGAATTCCAAGCGAATTCGAACTGGA
AGGCGACGAGGTCATCATCAGACAGGAAGAGAGCGGCCTGATCACGATCGAGCCGGTAAAGAAGAAGATGACGCCGCGGG
AGGTTATCGAGTGGCTTCGCGCTGAGCCGCCACTGCCGGAAGATGAATGGTTGCCGGAGATCGAAGACCTGCCGCCGCGG
GATGTCGATCTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References