Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 17597..18162 Replicon plasmid pPLP1
Accession NZ_CP020328
Organism Paenibacillus larvae subsp. pulvifaciens strain CCM 38

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag B5S25_RS22550 Protein ID WP_077997739.1
Coordinates 17833..18162 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag B5S25_RS22545 Protein ID WP_077997741.1
Coordinates 17597..17836 (+) Length 80 a.a.

Genomic Context

B5S25_RS22520B5S25_RS22530B5S25_RS22535B5S25_RS22545B5S25_RS22550B5S25_RS22570B5S25_RS22575B5S25_RS22580B5S25_RS22525B5S25_RS22540B5S25_RS23860B5S25_RS22555B5S25_RS22560B5S25_RS22565
Location: 13381..13827 (447 bp)
Type: Others
Protein ID: WP_077997735.1
Location: 14382..15839 (1458 bp)
Type: Others
Protein ID: WP_077997736.1
Location: 15877..16551 (675 bp)
Type: Others
Protein ID: WP_077997737.1
Location: 17597..17836 (240 bp)
Type: Antitoxin
Protein ID: WP_077997741.1
Location: 17833..18162 (330 bp)
Type: Toxin
Protein ID: WP_077997739.1
Location: 20764..21447 (684 bp)
Type: Others
Protein ID: WP_077996502.1
Location: 21585..22013 (429 bp)
Type: Others
Protein ID: WP_077997685.1
Location: 22010..22336 (327 bp)
Type: Others
Protein ID: WP_077997686.1
Location: 13941..14201 (261 bp)
Type: Others
Protein ID: Protein_17
Location: 16712..16963 (252 bp)
Type: Others
Protein ID: WP_077997738.1
Location: 16971..17117 (147 bp)
Type: Others
Protein ID: WP_155121122.1
Location: 18407..19045 (639 bp)
Type: Others
Protein ID: WP_077997682.1
Location: 19813..20091 (279 bp)
Type: Others
Protein ID: WP_077997683.1
Location: 20201..20407 (207 bp)
Type: Others
Protein ID: WP_077997684.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
B5S25_RS2252013381..13827+447WP_077997735.1hypothetical protein-
B5S25_RS2252513941..14201-261Protein_17transposase-
B5S25_RS2253014382..15839+1458WP_077997736.1SIR2 family protein-
B5S25_RS2253515877..16551+675WP_077997737.1TIR domain-containing protein-
B5S25_RS2254016712..16963-252WP_077997738.1hypothetical protein-
B5S25_RS2386016971..17117-147WP_155121122.1hypothetical protein-
B5S25_RS2254517597..17836+240WP_077997741.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
B5S25_RS2255017833..18162+330WP_077997739.1type II toxin-antitoxin system PemK/MazF family toxinToxin
B5S25_RS2255518407..19045-639WP_077997682.1hemolysin III family protein-
B5S25_RS2256019813..20091-279WP_077997683.1HU family DNA-binding protein-
B5S25_RS2256520201..20407-207WP_077997684.1cold-shock protein-
B5S25_RS2257020764..21447+684WP_077996502.1helix-turn-helix domain-containing protein-
B5S25_RS2257521585..22013+429WP_077997685.1IS3 family transposase-
B5S25_RS2258022010..22336+327WP_077997686.1IS3 family transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..6085560855


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-108)

Antitoxin

Antitoxin PemI-like

(1-79)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12407.45 Da        Isoelectric Point: 7.3587

>T74219 WP_077997739.1 NZ_CP020328:17833-18162 [Paenibacillus larvae subsp. pulvifaciens]
VTVVPDRGDIVYMDFNPQSGHEQAGWRPALVLSPKLFNATTNLAVVCPITSRIKGYLFEVHLPDAMMTKGVILVHQLKSA
DWRSRRLEIREKAPQEIIDEVIEKIHTFL

Download         Length: 330 bp

>T74219 NZ_CP020328:17833-18162 [Paenibacillus larvae subsp. pulvifaciens]
GTGACAGTTGTTCCAGATCGCGGTGATATCGTTTATATGGACTTTAATCCACAGAGCGGACATGAACAAGCCGGGTGGCG
ACCAGCCCTTGTACTGTCACCAAAATTATTTAATGCTACAACGAATCTTGCTGTAGTCTGCCCTATCACTTCTAGAATTA
AAGGCTACTTATTTGAAGTTCATCTTCCAGACGCAATGATGACAAAAGGTGTTATACTTGTGCACCAATTGAAAAGCGCC
GATTGGAGATCGCGGAGATTAGAAATTAGGGAGAAAGCACCACAAGAAATTATTGACGAAGTGATTGAAAAGATTCATAC
TTTCCTATAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8957.25 Da        Isoelectric Point: 5.6987

>AT74219 WP_077997741.1 NZ_CP020328:17597-17836 [Paenibacillus larvae subsp. pulvifaciens]
MSTLVSKWGNSLALRIPRHFAESLNLNEGSEVELKLTEDCLSVKPKKRKYTLEELCASIKDGNQHDLIDFGKPVGEEIW

Download         Length: 240 bp

>AT74219 NZ_CP020328:17597-17836 [Paenibacillus larvae subsp. pulvifaciens]
ATGAGCACGCTTGTAAGCAAATGGGGAAATAGTCTGGCACTTCGTATTCCCAGACATTTTGCTGAAAGCTTAAATCTTAA
TGAAGGCTCTGAAGTTGAATTAAAGCTAACAGAAGACTGCTTGAGTGTCAAGCCGAAGAAGAGAAAGTATACCCTTGAGG
AACTTTGTGCTTCTATTAAAGACGGTAATCAGCATGACCTTATTGATTTCGGTAAACCTGTTGGGGAGGAAATTTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References