Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 1309856..1310451 Replicon chromosome
Accession NZ_CP020327
Organism Paenibacillus larvae subsp. pulvifaciens strain CCM 38

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag B5S25_RS06995 Protein ID WP_077997555.1
Coordinates 1310158..1310451 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID W2E434
Locus tag B5S25_RS06990 Protein ID WP_036658190.1
Coordinates 1309856..1310125 (+) Length 90 a.a.

Genomic Context

B5S25_RS06970B5S25_RS06980B5S25_RS06990B5S25_RS06995B5S25_RS07000B5S25_RS07005B5S25_RS07010B5S25_RS06975B5S25_RS06985
Location: 1304869..1305483 (615 bp)
Type: Others
Protein ID: WP_077996009.1
Location: 1307691..1308977 (1287 bp)
Type: Others
Protein ID: WP_077996011.1
Location: 1309856..1310125 (270 bp)
Type: Antitoxin
Protein ID: WP_036658190.1
Location: 1310158..1310451 (294 bp)
Type: Toxin
Protein ID: WP_077997555.1
Location: 1310703..1310993 (291 bp)
Type: Others
Protein ID: WP_023483432.1
Location: 1310990..1313500 (2511 bp)
Type: Others
Protein ID: WP_077996013.1
Location: 1313605..1313901 (297 bp)
Type: Others
Protein ID: WP_036658187.1
Location: 1305515..1307431 (1917 bp)
Type: Others
Protein ID: WP_077996010.1
Location: 1309205..1309537 (333 bp)
Type: Others
Protein ID: WP_077996012.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
B5S25_RS069701304869..1305483+615WP_077996009.1sigma-70 family RNA polymerase sigma factor-
B5S25_RS069751305515..1307431-1917WP_077996010.1AAA family ATPase-
B5S25_RS069801307691..1308977+1287WP_077996011.1MFS transporter-
B5S25_RS069851309205..1309537-333WP_077996012.1hypothetical protein-
B5S25_RS069901309856..1310125+270WP_036658190.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
B5S25_RS069951310158..1310451+294WP_077997555.1type II toxin-antitoxin system PemK/MazF family toxinToxin
B5S25_RS070001310703..1310993+291WP_023483432.1metalloregulator ArsR/SmtB family transcription factor-
B5S25_RS070051310990..1313500+2511WP_077996013.1FAD-dependent oxidoreductase-
B5S25_RS070101313605..1313901+297WP_036658187.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-flankIS/Tn--1315004..13162271223


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-96)

Antitoxin

Antitoxin PemI-like

(11-89)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10996.75 Da        Isoelectric Point: 7.2775

>T74218 WP_077997555.1 NZ_CP020327:1310158-1310451 [Paenibacillus larvae subsp. pulvifaciens]
MDFNPQIGHEQAGRRPGLVVSPTSFNRVTGFIVVCPITRTVRNYPYEVPLPSDLMTEGVVLAHQVKSLDWKARKAEVREK
VPKEIIDDVLDLIHTFL

Download         Length: 294 bp

>T74218 NZ_CP020327:1310158-1310451 [Paenibacillus larvae subsp. pulvifaciens]
ATGGATTTTAACCCGCAGATTGGACATGAACAAGCCGGAAGAAGACCAGGCCTTGTTGTCTCTCCTACATCATTCAATAG
GGTAACAGGCTTTATAGTTGTATGCCCTATTACAAGAACCGTTAGGAATTATCCATATGAAGTTCCCCTCCCTTCCGATC
TTATGACCGAAGGTGTTGTTTTGGCTCATCAAGTAAAAAGCTTGGATTGGAAGGCAAGAAAGGCAGAAGTTCGGGAAAAA
GTACCAAAAGAAATTATTGACGATGTACTGGATTTAATTCACACTTTCCTATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10006.46 Da        Isoelectric Point: 5.7379

>AT74218 WP_036658190.1 NZ_CP020327:1309856-1310125 [Paenibacillus larvae subsp. pulvifaciens]
MGKDRERMSVMSTIVSKWGNSLAIRIPSNLAESLNIKEGSEVELSIMDSTLTIKPKKRKPTLEELLAKITDGNHHEEIDF
GKPEGNEVW

Download         Length: 270 bp

>AT74218 NZ_CP020327:1309856-1310125 [Paenibacillus larvae subsp. pulvifaciens]
ATGGGTAAAGACAGGGAAAGGATGAGTGTAATGAGCACAATTGTGAGCAAATGGGGAAACAGTCTCGCAATCCGCATTCC
AAGTAACCTGGCAGAAAGCCTAAACATAAAAGAGGGTTCTGAAGTTGAATTAAGCATCATGGATAGTACACTAACTATAA
AACCTAAAAAACGTAAGCCAACTCTCGAAGAATTACTGGCAAAAATAACAGACGGTAACCATCATGAGGAAATTGACTTT
GGAAAACCGGAGGGGAACGAGGTTTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A2L1TQJ8

References