Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-UPF0150
Location 1027535..1028179 Replicon chromosome
Accession NZ_CP020327
Organism Paenibacillus larvae subsp. pulvifaciens strain CCM 38

Toxin (Protein)


Gene name hicA Uniprot ID W2E6W9
Locus tag B5S25_RS05440 Protein ID WP_036654551.1
Coordinates 1027535..1027738 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag B5S25_RS05445 Protein ID WP_077995836.1
Coordinates 1027769..1028179 (+) Length 137 a.a.

Genomic Context

B5S25_RS05440B5S25_RS05445B5S25_RS05475B5S25_RS05425B5S25_RS05430B5S25_RS05435B5S25_RS05450B5S25_RS23275B5S25_RS05460B5S25_RS05465B5S25_RS05470B5S25_RS23980
Location: 1027535..1027738 (204 bp)
Type: Toxin
Protein ID: WP_036654551.1
Location: 1027769..1028179 (411 bp)
Type: Antitoxin
Protein ID: WP_077995836.1
Location: 1032361..1032888 (528 bp)
Type: Others
Protein ID: WP_077997537.1
Location: 1023791..1024012 (222 bp)
Type: Others
Protein ID: WP_077995833.1
Location: 1024029..1025891 (1863 bp)
Type: Others
Protein ID: WP_077995834.1
Location: 1025875..1026387 (513 bp)
Type: Others
Protein ID: WP_077995835.1
Location: 1028208..1028411 (204 bp)
Type: Others
Protein ID: WP_077995837.1
Location: 1028592..1028741 (150 bp)
Type: Others
Protein ID: Protein_1097
Location: 1028882..1030192 (1311 bp)
Type: Others
Protein ID: WP_024094814.1
Location: 1030331..1031263 (933 bp)
Type: Others
Protein ID: WP_036654839.1
Location: 1031244..1031945 (702 bp)
Type: Others
Protein ID: WP_077995841.1
Location: 1032173..1032277 (105 bp)
Type: Others
Protein ID: WP_188318623.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
B5S25_RS054251023791..1024012-222WP_077995833.1hypothetical protein-
B5S25_RS054301024029..1025891-1863WP_077995834.1phage terminase large subunit family protein-
B5S25_RS054351025875..1026387-513WP_077995835.1hypothetical protein-
B5S25_RS054401027535..1027738+204WP_036654551.1type II toxin-antitoxin system HicA family toxinToxin
B5S25_RS054451027769..1028179+411WP_077995836.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
B5S25_RS054501028208..1028411-204WP_077995837.1hypothetical protein-
B5S25_RS232751028592..1028741-150Protein_1097response regulator transcription factor-
B5S25_RS054601028882..1030192-1311WP_024094814.1purine/pyrimidine permease-
B5S25_RS054651030331..1031263-933WP_036654839.1dihydroorotate dehydrogenase-
B5S25_RS054701031244..1031945-702WP_077995841.1dihydroorotate dehydrogenase electron transfer subunit-
B5S25_RS239801032173..1032277-105WP_188318623.1sporulation protein YjcZ-
B5S25_RS054751032361..1032888+528WP_077997537.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--926221..1056119129898


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(10-66)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(5-107)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 7774.08 Da        Isoelectric Point: 10.8900

>T74217 WP_036654551.1 NZ_CP020327:1027535-1027738 [Paenibacillus larvae subsp. pulvifaciens]
MVNLNKAYSSREVIKILKEDGWIHKNTEGDHWHFIHPTKKGKVTVPHPKKGLKRRTTKSIFEQAGLI

Download         Length: 204 bp

>T74217 NZ_CP020327:1027535-1027738 [Paenibacillus larvae subsp. pulvifaciens]
ATGGTCAACCTCAATAAAGCATACTCATCAAGAGAGGTTATCAAAATCCTAAAAGAGGATGGCTGGATACATAAAAACAC
CGAAGGCGATCATTGGCACTTTATTCATCCCACTAAAAAAGGAAAGGTGACTGTACCCCATCCGAAAAAAGGCTTGAAAC
GTCGAACAACAAAAAGTATCTTTGAGCAGGCAGGGCTGATTTAA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 15121.91 Da        Isoelectric Point: 4.0257

>AT74217 WP_077995836.1 NZ_CP020327:1027769-1028179 [Paenibacillus larvae subsp. pulvifaciens]
MKYIYPAVFTPGEPDEGGFTVTFPDLPGCITEGDDLEEALHMAKDALGGHLYLMEEDGDEIPRSSQPDSIQLETGEFVSL
IQANTDFIRERIQSKAVNKTVTLPKWLNDVAAEEGINFSQTLQDALKQKLEIKDFS

Download         Length: 411 bp

>AT74217 NZ_CP020327:1027769-1028179 [Paenibacillus larvae subsp. pulvifaciens]
ATGAAATACATTTACCCTGCTGTTTTTACCCCCGGCGAACCAGACGAAGGAGGCTTTACTGTCACATTCCCTGATCTTCC
TGGATGCATCACAGAAGGCGATGATCTGGAAGAAGCCCTACACATGGCAAAAGATGCTCTTGGCGGCCATTTATACCTGA
TGGAAGAGGATGGCGACGAAATACCTCGTTCATCACAACCAGACTCTATACAGCTTGAAACTGGAGAATTTGTTTCTCTT
ATTCAGGCTAATACAGATTTCATCCGCGAAAGGATTCAGAGTAAAGCCGTGAATAAGACCGTCACTCTTCCAAAATGGCT
TAATGATGTAGCAGCGGAAGAAGGCATTAACTTTTCTCAGACTCTTCAGGATGCATTAAAACAAAAGCTTGAAATCAAAG
ACTTCTCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A2L1UH89

Antitoxin

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Source
ID
Structure
No matching records found

References