Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 5175968..5176571 Replicon chromosome
Accession NZ_CP020114
Organism Nodularia spumigena UHCC 0039

Toxin (Protein)


Gene name relE Uniprot ID A0A2S0QBB6
Locus tag BMF81_RS23165 Protein ID WP_006196814.1
Coordinates 5175968..5176324 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A166JFP1
Locus tag BMF81_RS23170 Protein ID WP_006196813.1
Coordinates 5176314..5176571 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BMF81_RS23140 5171265..5171381 - 117 WP_006196819.1 DUF4351 domain-containing protein -
BMF81_RS23145 5171594..5171854 + 261 WP_006196818.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
BMF81_RS23150 5171842..5172171 + 330 WP_006196817.1 type II toxin-antitoxin system PemK/MazF family toxin -
BMF81_RS23155 5172244..5175036 - 2793 WP_006196816.1 preprotein translocase subunit SecA -
BMF81_RS23160 5175292..5175885 - 594 WP_006196815.1 cytochrome c -
BMF81_RS23165 5175968..5176324 - 357 WP_006196814.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BMF81_RS23170 5176314..5176571 - 258 WP_006196813.1 hypothetical protein Antitoxin
BMF81_RS23175 5176633..5177541 - 909 WP_006196812.1 MoxR family ATPase -
BMF81_RS23180 5177650..5178708 - 1059 WP_006196811.1 bifunctional riboflavin kinase/FAD synthetase -
BMF81_RS23185 5179450..5180247 - 798 WP_006196810.1 5'/3'-nucleotidase SurE -
BMF81_RS23190 5180514..5181506 + 993 WP_107806948.1 phenylalanine--tRNA ligase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(32-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13533.38 Da        Isoelectric Point: 6.3735

>T74177 WP_006196814.1 NZ_CP020114:c5176324-5175968 [Nodularia spumigena UHCC 0039]
MPNEQPMVLIDLTPEYKQNLRDLSKRFRNIRSDLQGIIEQLQQGSVLGDRIGGLGEEYVVYKARVRNSNIQRGKSAGYRL
IYQVESPTSILLLTIYSKSDREDISVNEIRDIVTDFSV

Download         Length: 357 bp

>T74177 NZ_CP020114:c5176324-5175968 [Nodularia spumigena UHCC 0039]
ATGCCGAATGAACAGCCAATGGTATTAATCGATTTAACTCCTGAATATAAACAAAACTTACGTGACCTTTCCAAAAGATT
TCGCAATATTCGTTCTGACTTACAAGGGATTATTGAACAATTACAACAAGGTAGTGTTCTGGGAGATAGAATTGGCGGCC
TTGGTGAGGAATATGTTGTATATAAGGCGAGAGTTCGCAACAGTAATATCCAAAGAGGTAAAAGTGCTGGATACCGCTTA
ATTTATCAAGTTGAATCACCTACAAGTATTTTGCTACTAACAATTTATTCCAAGTCTGACCGAGAAGATATTAGTGTAAA
TGAAATCCGAGATATTGTGACTGATTTTTCAGTTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9359.68 Da        Isoelectric Point: 4.2213

>AT74177 WP_006196813.1 NZ_CP020114:c5176571-5176314 [Nodularia spumigena UHCC 0039]
MKAIEVTGKIDAEGNLVLDQPIQGTTYPHQVRVIVLVPEQVEIEAVDPDDTPVEEIKASLKRALQQAKAGQRLPLSQMWE
GIDAE

Download         Length: 258 bp

>AT74177 NZ_CP020114:c5176571-5176314 [Nodularia spumigena UHCC 0039]
ATGAAAGCTATCGAAGTTACTGGCAAGATTGACGCTGAGGGCAATTTAGTTCTAGATCAGCCGATTCAGGGAACAACTTA
TCCTCATCAAGTGCGGGTAATTGTGTTAGTTCCAGAACAGGTAGAAATAGAAGCAGTTGACCCAGATGATACACCCGTTG
AAGAAATTAAAGCCAGCTTGAAAAGAGCTTTACAACAAGCCAAAGCAGGACAACGCCTACCATTATCCCAAATGTGGGAG
GGAATCGATGCCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S0QBB6

Antitoxin

Source ID Structure
AlphaFold DB A0A166JFP1

References