74072

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2435324..2435901 Replicon chromosome
Accession NZ_CP020100
Organism Pseudomonas sp. S-6-2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag BVH74_RS11240 Protein ID WP_080050159.1
Coordinates 2435527..2435901 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag BVH74_RS11235 Protein ID WP_080050158.1
Coordinates 2435324..2435530 (+) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BVH74_RS11210 2430367..2431323 + 957 WP_080050154.1 SDR family oxidoreductase -
BVH74_RS11215 2431320..2432345 + 1026 WP_080050155.1 glycosyltransferase family 4 protein -
BVH74_RS11220 2432470..2434452 + 1983 WP_080051705.1 polysaccharide biosynthesis protein -
BVH74_RS11225 2434534..2434956 + 423 WP_080050156.1 nucleotidyltransferase substrate binding protein -
BVH74_RS11230 2434943..2435257 + 315 WP_080050157.1 nucleotidyltransferase domain-containing protein -
BVH74_RS11235 2435324..2435530 + 207 WP_080050158.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
BVH74_RS11240 2435527..2435901 + 375 WP_080050159.1 PIN domain-containing protein Toxin
BVH74_RS11245 2435964..2436842 + 879 WP_080050160.1 UTP--glucose-1-phosphate uridylyltransferase GalU -
BVH74_RS11250 2436942..2437430 + 489 WP_080050161.1 helix-turn-helix domain-containing protein -
BVH74_RS11255 2437423..2437716 + 294 WP_080050162.1 hypothetical protein -
BVH74_RS11260 2437724..2439019 + 1296 WP_080050163.1 UDP-glucose/GDP-mannose dehydrogenase family protein -
BVH74_RS11265 2439019..2440659 + 1641 WP_080050164.1 glucose-6-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-113)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-43)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13542.70 Da        Isoelectric Point: 5.6606

>T74072 WP_080050159.1 NZ_CP020100:2435527-2435901 [Pseudomonas sp. S-6-2]
VNVLVDTSVWVSHFKRANESLVSLLLQDRVLTHSMVIGELACGTPPSRQQTFTALSQLEPAVTATNDEVMALIDREQLFG
LGCGWVDISLLASALITPACRLWTLDKRLAKLAARFEVGFPAGY

Download         Length: 375 bp

>T74072 NZ_CP020100:2435527-2435901 [Pseudomonas sp. S-6-2]
GTGAATGTTCTGGTTGATACCTCCGTCTGGGTGTCGCATTTCAAGAGGGCTAACGAGAGCTTGGTTAGTCTGTTGCTGCA
GGATCGGGTGCTGACACATTCGATGGTAATTGGTGAGTTGGCTTGTGGAACGCCACCATCGCGCCAGCAAACTTTTACCG
CACTCTCTCAGCTGGAGCCTGCAGTTACGGCGACAAATGACGAGGTCATGGCTTTGATCGACAGGGAGCAACTGTTTGGT
CTGGGCTGTGGTTGGGTGGACATATCGCTGCTGGCTTCCGCATTGATTACGCCTGCTTGCCGTTTATGGACTCTCGACAA
GAGGTTGGCAAAACTGGCGGCCCGCTTTGAGGTTGGCTTCCCCGCTGGGTATTAG

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7420.47 Da        Isoelectric Point: 8.7167

>AT74072 WP_080050158.1 NZ_CP020100:2435324-2435530 [Pseudomonas sp. S-6-2]
MRTTVSIDDELYQQALAFAGPDVSNVDLVREAMRTFVRVQAAKRLAALGGTAPEMKTIPRRRAAGDSE

Download         Length: 207 bp

>AT74072 NZ_CP020100:2435324-2435530 [Pseudomonas sp. S-6-2]
ATGCGTACAACAGTGTCCATTGATGATGAGCTATATCAGCAGGCTTTGGCGTTCGCGGGACCGGACGTGAGTAACGTCGA
CCTGGTCCGTGAGGCCATGCGTACTTTTGTGCGTGTTCAGGCGGCTAAGCGCTTGGCCGCTCTTGGTGGTACAGCCCCAG
AGATGAAGACGATACCGCGTAGGCGAGCGGCGGGTGACAGTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References