Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA(toxin)
Location 3452653..3454436 Replicon chromosome
Accession NZ_CP020089
Organism Enterobacter cloacae strain PIMB10EC27

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag B2J95_RS16910 Protein ID WP_058678814.1
Coordinates 3452653..3454002 (+) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag B2J95_RS16915 Protein ID WP_058678815.1
Coordinates 3453999..3454436 (+) Length 146 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B2J95_RS16885 3448473..3449405 - 933 WP_013097946.1 tRNA dihydrouridine(16) synthase DusC -
B2J95_RS16890 3449573..3449971 + 399 WP_023619766.1 CidA/LrgA family protein -
B2J95_RS16895 3449968..3450663 + 696 WP_013097948.1 CidB/LrgB family autolysis modulator -
B2J95_RS16900 3450793..3451677 + 885 WP_023619765.1 cytidine deaminase -
B2J95_RS16905 3451805..3452518 + 714 WP_023619764.1 outer membrane permeability protein SanA -
B2J95_RS16910 3452653..3454002 + 1350 WP_058678814.1 type II toxin-antitoxin system HipA family toxin Toxin
B2J95_RS16915 3453999..3454436 + 438 WP_058678815.1 helix-turn-helix domain-containing protein Antitoxin
B2J95_RS16920 3454488..3455498 - 1011 WP_013097952.1 galactose/methyl galactoside ABC transporter permease MglC -
B2J95_RS16925 3455514..3457034 - 1521 WP_029883073.1 galactose/methyl galactoside ABC transporter ATP-binding protein MglA -
B2J95_RS16930 3457115..3458113 - 999 WP_014832691.1 galactose/glucose ABC transporter substrate-binding protein MglB -
B2J95_RS16935 3458409..3459431 - 1023 WP_058678816.1 HTH-type transcriptional regulator GalS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-406)

Antitoxin

Cro/C1-type helix-turn-helix domain

(78-129)


Sequences

Toxin        


Download         Length: 450 a.a.        Molecular weight: 51148.71 Da        Isoelectric Point: 4.5681

>T74042 WP_058678814.1 NZ_CP020089:3452653-3454002 [Enterobacter cloacae]
METLTVQAYLNETWTDIALIKYPGSENNDWNTTQLDYLTEYAINFLNYDDFHAVSVNHPVSLFFDDQGQPGWLRFIDDII
PAGASRRYWINALDISELPVGQQNFLLLKFGTMSPVGNLRIKESVPEWNEFARTKTFTVADVIDRAADFLDYAQERGAAA
GGATGAGGEAPKLLLRCSETDAIWIDTWQNEPDNRDRYYLVKYPRGNRTEVDCNILRAEFHYYHELNAMGFSTIPVDTMR
LEEGSHYPSLWLPRFDIVRNEQDQLIRLGMESVYSLLQKAPGTLLDHEATLRALINKITSSHMVQQQGYQFDIPGFVTEW
VRRDLLNIIFGNSDNHGRNTAFVKAENHIMLSPVYDFAPMKADPEGIPRTLKWSLSCESGGDYNFNAIAQALAEWIPPTT
LLDALHETAVQLIDLPERLEARGVPDQIMEMPAIGFRYIPNKLSRWGLL

Download         Length: 1350 bp

>T74042 NZ_CP020089:3452653-3454002 [Enterobacter cloacae]
ATGGAGACGTTAACCGTACAAGCATATCTGAATGAAACATGGACGGATATCGCCCTCATCAAATATCCGGGAAGCGAAAA
CAATGACTGGAACACCACACAGTTAGACTATCTTACTGAGTATGCGATTAATTTTCTTAACTATGATGATTTTCACGCGG
TCTCAGTCAACCACCCTGTATCACTCTTTTTTGATGACCAGGGTCAACCGGGCTGGCTGCGATTTATCGACGATATCATT
CCTGCCGGAGCCAGTCGCCGTTATTGGATAAATGCACTCGATATCAGTGAGTTGCCTGTTGGTCAGCAGAATTTTTTATT
GTTGAAATTTGGCACAATGTCCCCTGTCGGGAATTTGCGTATAAAAGAATCCGTTCCTGAATGGAATGAATTCGCACGCA
CTAAAACGTTTACGGTTGCGGACGTCATCGATCGTGCGGCAGATTTTCTGGATTATGCCCAGGAAAGAGGCGCGGCGGCG
GGTGGTGCAACCGGCGCTGGGGGTGAAGCGCCGAAACTGTTGCTGCGCTGTAGTGAAACGGATGCCATATGGATCGATAC
CTGGCAAAACGAACCGGATAACCGGGACCGCTATTATTTGGTTAAATATCCACGCGGAAACAGAACAGAAGTTGATTGTA
ATATTCTCCGGGCTGAATTTCATTATTACCATGAGCTTAACGCGATGGGCTTTTCCACGATCCCAGTGGACACAATGCGC
CTTGAAGAAGGTAGCCACTATCCTTCGCTGTGGTTGCCACGTTTCGACATAGTGAGAAATGAGCAGGATCAACTGATCAG
GCTGGGTATGGAATCGGTGTATTCACTATTACAAAAAGCACCCGGTACTCTCCTGGATCATGAGGCAACGCTGCGCGCGT
TAATTAATAAAATTACCTCCAGCCATATGGTTCAGCAGCAGGGCTATCAATTTGATATCCCTGGTTTTGTAACAGAATGG
GTACGTCGCGATCTGTTAAATATTATTTTTGGGAATAGTGACAACCATGGGCGAAATACCGCCTTTGTGAAAGCTGAAAA
TCACATTATGCTCTCCCCTGTTTATGATTTTGCTCCAATGAAAGCCGATCCAGAGGGGATACCGCGAACCCTGAAGTGGT
CATTATCTTGTGAATCAGGGGGGGATTATAATTTCAACGCTATCGCGCAAGCGCTGGCGGAGTGGATCCCTCCCACAACT
TTACTTGACGCTCTGCATGAGACAGCCGTCCAGCTCATCGATCTCCCGGAAAGGCTGGAGGCGCGAGGCGTTCCCGACCA
AATAATGGAAATGCCCGCGATTGGTTTTCGCTATATTCCGAATAAACTTTCTCGTTGGGGTTTATTATGA

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 16276.77 Da        Isoelectric Point: 10.6347

>AT74042 WP_058678815.1 NZ_CP020089:3453999-3454436 [Enterobacter cloacae]
MKTSNKFESELLQTLARVRSVNEKRRHDEDEDPDKSSVVKRQRVSPGLTRISTLDRQAVLHAAIRDILLGKITQGEALKR
LRVEVLGMKQDEYAKLVSVSRKTLSDVENGRGNYSADIINKIFKPFGLQTGLVPISKSLIASLFT

Download         Length: 438 bp

>AT74042 NZ_CP020089:3453999-3454436 [Enterobacter cloacae]
ATGAAAACATCTAATAAGTTTGAATCAGAGCTTCTACAAACATTAGCCCGGGTACGCAGCGTAAATGAAAAGCGACGTCA
TGATGAGGATGAAGATCCGGACAAGTCATCGGTAGTAAAGAGGCAACGCGTTTCACCAGGCTTAACACGGATTAGTACTC
TTGATCGCCAGGCTGTACTGCATGCAGCCATACGGGACATTTTACTGGGTAAAATCACACAGGGTGAGGCGCTGAAAAGA
CTCAGGGTCGAAGTGTTGGGGATGAAGCAGGATGAATATGCAAAGCTGGTCAGCGTATCCCGGAAAACATTGTCGGATGT
AGAAAATGGCAGAGGCAATTATTCCGCTGACATTATAAATAAAATCTTTAAACCCTTTGGGCTTCAAACCGGACTGGTGC
CCATTTCCAAATCGCTTATAGCTTCACTTTTCACGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References