Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 14712..15234 Replicon plasmid unnamed2
Accession NZ_CP020088
Organism Shigella flexneri 1a strain 0670

Toxin (Protein)


Gene name relE Uniprot ID G3CAN5
Locus tag B4376_RS26730 Protein ID WP_000220560.1
Coordinates 14953..15234 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag B4376_RS26725 Protein ID WP_000121743.1
Coordinates 14712..14963 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B4376_RS26690 (B4376_26835) 9792..10454 + 663 WP_000516402.1 division plane positioning ATPase MipZ -
B4376_RS26695 (B4376_26840) 10552..10833 + 282 WP_001185482.1 hypothetical protein -
B4376_RS26700 (B4376_26845) 10858..11835 + 978 WP_024127745.1 hypothetical protein -
B4376_RS26705 (B4376_26850) 11832..12188 - 357 WP_052921318.1 DNA distortion polypeptide 3 -
B4376_RS26710 (B4376_26855) 12325..12771 - 447 WP_001074386.1 hypothetical protein -
B4376_RS26715 (B4376_26860) 12796..13650 - 855 WP_001239324.1 replication initiation protein -
B4376_RS26725 (B4376_26870) 14712..14963 + 252 WP_000121743.1 plasmid stabilization protein Antitoxin
B4376_RS26730 (B4376_26875) 14953..15234 + 282 WP_000220560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
B4376_RS26735 (B4376_26880) 15380..15703 + 324 WP_001181903.1 hypothetical protein -
B4376_RS26740 (B4376_26885) 15748..15993 + 246 WP_001550454.1 hypothetical protein -
B4376_RS26745 (B4376_26890) 15983..16198 + 216 WP_052921379.1 hypothetical protein -
B4376_RS26750 (B4376_26895) 16291..16620 + 330 WP_000866648.1 hypothetical protein -
B4376_RS26755 (B4376_26900) 16663..16842 + 180 WP_000439078.1 hypothetical protein -
B4376_RS28050 (B4376_26905) 16912..17061 + 150 WP_000003880.1 hypothetical protein -
B4376_RS26765 (B4376_26910) 17074..17346 + 273 WP_000160399.1 hypothetical protein -
B4376_RS26770 (B4376_26915) 17672..18217 + 546 WP_000757693.1 DNA distortion polypeptide 1 -
B4376_RS26775 (B4376_26920) 18220..19386 + 1167 WP_000539529.1 MobP1 family relaxase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaTEM-1B / qnrS1 - 1..47674 47674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11005.83 Da        Isoelectric Point: 10.5938

>T74027 WP_000220560.1 NZ_CP020088:14953-15234 [Shigella flexneri 1a]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR

Download         Length: 282 bp

>T74027 NZ_CP020088:14953-15234 [Shigella flexneri 1a]
ATGACCTATGAACTGGCTTTTGACCGTAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAACTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATATCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCCGTTGGAAGA
AGGGAAAGCAGCGAAGTCTATCAGATCGCAGATTTGCGCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT74027 WP_000121743.1 NZ_CP020088:14712-14963 [Shigella flexneri 1a]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp

>AT74027 NZ_CP020088:14712-14963 [Shigella flexneri 1a]
ATGAGCTATCAAATTCTGACAACCACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G3CAN5

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References