Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 3290241..3291036 | Replicon | chromosome |
| Accession | NZ_CP020086 | ||
| Organism | Shigella flexneri 1a strain 0670 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | Q93EZ7 |
| Locus tag | B4376_RS17880 | Protein ID | WP_000854917.1 |
| Coordinates | 3290241..3290615 (-) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | D2ACA1 |
| Locus tag | B4376_RS17885 | Protein ID | WP_001280958.1 |
| Coordinates | 3290662..3291036 (-) | Length | 125 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| B4376_RS17845 (3285850) | 3285850..3286788 | - | 939 | Protein_3209 | glyoxylate/hydroxypyruvate reductase GhrA | - |
| B4376_RS17855 (3287260) | 3287260..3287541 | - | 282 | Protein_3210 | DUF4942 domain-containing protein | - |
| B4376_RS17860 (3287823) | 3287823..3288827 | - | 1005 | WP_001179707.1 | IS110-like element ISSfl8 family transposase | - |
| B4376_RS17865 (3288899) | 3288899..3289459 | - | 561 | Protein_3212 | DUF4942 domain-containing protein | - |
| B4376_RS17870 (3289544) | 3289544..3289741 | - | 198 | WP_000839282.1 | DUF957 domain-containing protein | - |
| B4376_RS17875 (3289753) | 3289753..3290244 | - | 492 | WP_000976828.1 | DUF5983 family protein | - |
| B4376_RS17880 (3290241) | 3290241..3290615 | - | 375 | WP_000854917.1 | TA system toxin CbtA family protein | Toxin |
| B4376_RS17885 (3290662) | 3290662..3291036 | - | 375 | WP_001280958.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| B4376_RS17895 (3291199) | 3291199..3291420 | - | 222 | WP_001220314.1 | DUF987 domain-containing protein | - |
| B4376_RS17900 (3291483) | 3291483..3291959 | - | 477 | WP_005011624.1 | RadC family protein | - |
| B4376_RS27415 (3291975) | 3291975..3292448 | - | 474 | WP_005011597.1 | antirestriction protein | - |
| B4376_RS17910 (3292790) | 3292790..3293611 | - | 822 | WP_001234584.1 | DUF932 domain-containing protein | - |
| B4376_RS27425 (3293711) | 3293711..3293884 | - | 174 | WP_000088744.1 | DUF905 family protein | - |
| B4376_RS28445 (3294004) | 3294004..3294267 | - | 264 | WP_000466628.1 | DNA polymerase III subunit gamma/tau | - |
| B4376_RS17925 (3295206) | 3295206..3295622 | - | 417 | WP_000275180.1 | AraC family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | tet(B) / catA1 / blaOXA-1 / ant(3'')-Ia | csgB / csgD / csgE / csgF / csgG | 3280170..3334526 | 54356 | |
| - | flank | IS/Tn | - | - | 3287823..3288827 | 1004 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 14145.22 Da Isoelectric Point: 7.7761
>T74018 WP_000854917.1 NZ_CP020086:c3290615-3290241 [Shigella flexneri 1a]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
Download Length: 375 bp
>T74018 NZ_CP020086:c3290615-3290241 [Shigella flexneri 1a]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGTCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGTCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
Antitoxin
Download Length: 125 a.a. Molecular weight: 13793.62 Da Isoelectric Point: 6.4651
>AT74018 WP_001280958.1 NZ_CP020086:c3291036-3290662 [Shigella flexneri 1a]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLYYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAPATTS
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLYYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAPATTS
Download Length: 375 bp
>AT74018 NZ_CP020086:c3291036-3290662 [Shigella flexneri 1a]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGTATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGTATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q93EZ7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0K4PAV2 |