Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2766762..2767288 | Replicon | chromosome |
| Accession | NZ_CP020086 | ||
| Organism | Shigella flexneri 1a strain 0670 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | B4376_RS14805 | Protein ID | WP_000323025.1 |
| Coordinates | 2767001..2767288 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | B4376_RS14800 | Protein ID | WP_000534858.1 |
| Coordinates | 2766762..2767001 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| B4376_RS14775 (2762410) | 2762410..2762613 | + | 204 | WP_000214712.1 | putative selenium delivery protein YdfZ | - |
| B4376_RS14780 (2762649) | 2762649..2764109 | - | 1461 | WP_000527804.1 | mannitol dehydrogenase family protein | - |
| B4376_RS14785 (2764198) | 2764198..2765217 | - | 1020 | Protein_2644 | MHS family MFS transporter YdfJ | - |
| B4376_RS14790 (2765279) | 2765279..2766435 | + | 1157 | Protein_2645 | IS3 family transposase | - |
| B4376_RS14795 (2766432) | 2766432..2766737 | - | 306 | WP_071818640.1 | hypothetical protein | - |
| B4376_RS14800 (2766762) | 2766762..2767001 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| B4376_RS14805 (2767001) | 2767001..2767288 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| B4376_RS14810 (2767360) | 2767360..2767515 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| B4376_RS14815 (2767733) | 2767733..2767984 | + | 252 | WP_000980987.1 | protein Rem | - |
| B4376_RS14820 (2768051) | 2768051..2768329 | + | 279 | Protein_2651 | hypothetical protein | - |
| B4376_RS14825 (2768331) | 2768331..2769380 | + | 1050 | WP_001265249.1 | DUF968 domain-containing protein | - |
| B4376_RS14830 (2769393) | 2769393..2769749 | + | 357 | WP_000904111.1 | RusA family crossover junction endodeoxyribonuclease | - |
| B4376_RS14835 (2769764) | 2769764..2770585 | + | 822 | WP_000762882.1 | antitermination protein | - |
| B4376_RS27325 (2771506) | 2771506..2771614 | + | 109 | Protein_2655 | DUF3927 family protein | - |
| B4376_RS14860 (2771895) | 2771895..2772230 | - | 336 | WP_000871291.1 | anti-adapter protein IraM | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2764198..2774589 | 10391 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T74015 WP_000323025.1 NZ_CP020086:2767001-2767288 [Shigella flexneri 1a]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T74015 NZ_CP020086:2767001-2767288 [Shigella flexneri 1a]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT74015 WP_000534858.1 NZ_CP020086:2766762-2767001 [Shigella flexneri 1a]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT74015 NZ_CP020086:2766762-2767001 [Shigella flexneri 1a]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|