Detailed information of TA system TA073999

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 1768378..1769155
• Replicon: chromosome
• Accession: NZ_CP020085
• Organism: Glaesserella parasuis strain CL120103

Toxin (Protein)

• Gene name: TacT3
• Uniprot ID: -
• Locus tag: B4X03_RS08470
• Protein ID: WP_021115013.1
• Coordinates: 1768655..1769155 (+)
• Length: 167 a.a.

Antitoxin (Protein)

• Gene name: TacA3
• Uniprot ID: U4SPD7
• Locus tag: B4X03_RS08465
• Protein ID: WP_005710653.1
• Coordinates: 1768378..1768665 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B4X03_RS08445	1764744..1765244	-	501	WP_021109667.1	CvpA family protein	-
B4X03_RS08450	1765350..1766927	-	1578	WP_082259322.1	FAD-binding protein	-
B4X03_RS08455	1767102..1767839	-	738	WP_082259324.1	peptidoglycan editing factor PgeF	-
B4X03_RS08460	1767843..1768232	-	390	WP_026916905.1	RidA family protein	-
B4X03_RS08465	1768378..1768665	+	288	WP_005710653.1	DUF1778 domain-containing protein	Antitoxin
B4X03_RS08470	1768655..1769155	+	501	WP_021115013.1	GNAT family N-acetyltransferase	Toxin
B4X03_RS08475	1769183..1770184	+	1002	WP_010786647.1	nucleoid-associated protein YejK	-
B4X03_RS08480	1770245..1770580	+	336	WP_005710658.1	outer membrane protein assembly factor BamE	-
B4X03_RS08485	1770735..1771850	+	1116	WP_082259326.1	anhydro-N-acetylmuramic acid kinase	-
B4X03_RS08490	1771862..1772776	+	915	WP_082259327.1	N-acetylmuramic acid 6-phosphate etherase	-
B4X03_RS08495	1772818..1773132	+	315	WP_005710664.1	YqcC family protein	-
B4X03_RS08500	1773129..1773857	+	729	WP_082259328.1	tRNA pseudouridine(65) synthase TruC	-
B4X03_RS08505	1773875..1774030	+	156	WP_005710668.1	YoaH family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Vibrio phage ICP1, Orf50 (4-87)

Sequences

Toxin

Protein

• Length: 167 a.a.
• Molecular weight: 19055.23 Da
• Isoelectric Point: 9.3198

>T73999 WP_021115013.1 NZ_CP020085:1768655-1769155 [Glaesserella parasuis]
MKSKFIEEPLTKHHQREAFDCGNLEMNRFFKQYARQSHEKGTSKTYISRHLDSQQIIGFYTITLSALDQQHLPELCKKRF
GYHPIPLFTLARLAVDIRYQKQGIGGMLLVKALKRCAIVAEQVGGIGLLIEAKDEDISRWYQSYGAIPLENMPLTLILLF
DTIKGL

Nucleotide

• Length: 501 bp

>T73999 NZ_CP020085:1768655-1769155 [Glaesserella parasuis]
ATGAAGAGTAAATTTATTGAAGAGCCTTTAACGAAGCATCATCAACGTGAAGCCTTTGATTGCGGAAATCTAGAGATGAA
CCGATTTTTTAAACAATACGCTCGGCAATCTCACGAAAAAGGGACATCAAAAACTTACATTAGCCGACACTTAGACAGTC
AACAGATTATCGGATTTTATACAATCACCTTAAGTGCATTAGACCAGCAACACTTACCCGAACTATGCAAAAAACGTTTT
GGCTACCACCCTATTCCGCTCTTTACATTAGCAAGACTTGCAGTGGATATTCGCTATCAAAAACAAGGCATTGGCGGAAT
GCTGTTGGTTAAAGCTCTCAAACGCTGTGCCATCGTTGCCGAACAAGTCGGGGGAATTGGGCTTCTCATTGAAGCAAAAG
ATGAAGACATTTCTCGTTGGTATCAATCTTATGGTGCTATTCCATTGGAAAATATGCCATTAACCTTAATTCTACTCTTT
GATACAATCAAAGGACTTTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10917.47 Da
• Isoelectric Point: 6.4650

>AT73999 WP_005710653.1 NZ_CP020085:1768378-1768665 [Glaesserella parasuis]
MPQIANALNDRMSIRISTEDKQTLIRAVALTHTNITEFVLQRILPSAREIIQQYDNRQFSPQDLSLIMELLDNPPKANTK
LQQAAKLAKESYHEE

Nucleotide

• Length: 288 bp

>AT73999 NZ_CP020085:1768378-1768665 [Glaesserella parasuis]
ATGCCACAAATTGCAAATGCCCTTAACGATAGAATGTCTATTCGCATTAGTACGGAAGACAAGCAGACTTTAATTAGAGC
CGTTGCACTTACCCATACGAATATTACGGAATTTGTATTACAACGCATTTTGCCTAGTGCCAGAGAAATTATTCAGCAGT
ATGATAATCGGCAATTTTCACCGCAAGATCTCTCGTTGATTATGGAATTGCTTGATAATCCGCCGAAAGCTAATACAAAA
CTACAACAAGCGGCGAAATTAGCAAAGGAAAGCTATCATGAAGAGTAA

Structures

Antitoxin

• AlphaFold DB: U4SPD7