Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 1461878..1462514 Replicon chromosome
Accession NZ_CP020085
Organism Glaesserella parasuis strain CL120103

Toxin (Protein)


Gene name hicA Uniprot ID A0A836YYT4
Locus tag B4X03_RS07150 Protein ID WP_021113607.1
Coordinates 1462338..1462514 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A143CEF9
Locus tag B4X03_RS07145 Protein ID WP_021113608.1
Coordinates 1461878..1462291 (-) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B4X03_RS07130 1456944..1457363 + 420 WP_021113612.1 HD domain-containing protein -
B4X03_RS07135 1457485..1461135 + 3651 WP_082259217.1 tape measure protein -
B4X03_RS07140 1461168..1461881 + 714 WP_082259218.1 phage minor tail protein L -
B4X03_RS07145 1461878..1462291 - 414 WP_021113608.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
B4X03_RS07150 1462338..1462514 - 177 WP_021113607.1 type II toxin-antitoxin system HicA family toxin Toxin
B4X03_RS11835 1462600..1462818 + 219 Protein_1385 C40 family peptidase -
B4X03_RS11840 1462876..1463829 + 954 Protein_1386 phage tail protein -
B4X03_RS07160 1463835..1464122 + 288 Protein_1387 excinuclease ABC subunit UvrA -
B4X03_RS07165 1464206..1464586 + 381 WP_043896063.1 YacL family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1445331..1482106 36775


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(8-63)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6704.84 Da        Isoelectric Point: 10.8513

>T73996 WP_021113607.1 NZ_CP020085:c1462514-1462338 [Glaesserella parasuis]
MKQSEFLRWLIAQGVVKEEGSKHIKLYYNGNQSTMPRQPSKEIKNGTMRAIKKQLGLN

Download         Length: 177 bp

>T73996 NZ_CP020085:c1462514-1462338 [Glaesserella parasuis]
ATGAAACAAAGTGAATTTTTAAGATGGCTAATTGCTCAAGGGGTAGTAAAGGAAGAAGGCTCAAAGCACATCAAACTTTA
TTACAACGGTAATCAATCAACAATGCCAAGACAACCTAGCAAGGAAATCAAAAACGGCACAATGAGAGCGATTAAAAAGC
AATTAGGTTTAAACTAA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15572.78 Da        Isoelectric Point: 4.3878

>AT73996 WP_021113608.1 NZ_CP020085:c1462291-1461878 [Glaesserella parasuis]
MLYPARFEFEDGSYNVSFRDIPEALTCGDNYEDALEMAKDALLTSMDFYFEDHRKVPLPSPPQEGEVLIELPTSIFAKVL
LLNEMVDQNISNVELAKRIAVKPQEVQRITNLGHSTKIDTIARAINALDKQFELRVV

Download         Length: 414 bp

>AT73996 NZ_CP020085:c1462291-1461878 [Glaesserella parasuis]
ATGCTGTATCCAGCACGATTCGAATTTGAAGATGGTAGTTATAATGTTTCATTCCGTGATATTCCTGAAGCGTTGACTTG
CGGTGATAACTACGAAGACGCTTTAGAGATGGCAAAAGATGCATTGCTTACCAGTATGGATTTTTATTTCGAAGATCATC
GCAAAGTGCCGTTACCAAGCCCACCACAAGAAGGCGAAGTGCTGATCGAATTACCGACAAGTATTTTCGCCAAAGTGCTA
TTGCTAAATGAGATGGTCGATCAGAATATCTCCAATGTGGAATTAGCAAAACGAATTGCCGTAAAACCGCAAGAAGTACA
GCGTATTACTAATCTTGGGCATAGTACAAAAATCGATACTATTGCAAGAGCGATTAATGCACTCGACAAACAGTTTGAAT
TACGTGTTGTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A836YYT4

Antitoxin

Source ID Structure
AlphaFold DB A0A143CEF9

References