Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 1139716..1140251 Replicon chromosome
Accession NZ_CP020085
Organism Glaesserella parasuis strain CL120103

Toxin (Protein)


Gene name relE Uniprot ID A0A837AG59
Locus tag B4X03_RS05690 Protein ID WP_010785923.1
Coordinates 1139967..1140251 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A837AF96
Locus tag B4X03_RS05685 Protein ID WP_021118772.1
Coordinates 1139716..1139970 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B4X03_RS05665 1135272..1135814 + 543 WP_010785927.1 adenine phosphoribosyltransferase -
B4X03_RS05670 1135902..1137920 + 2019 WP_021114606.1 DNA polymerase III subunit gamma/tau -
B4X03_RS05675 1137926..1138822 + 897 WP_005712691.1 ABC transporter ATP-binding protein -
B4X03_RS05680 1138844..1139599 + 756 WP_021112098.1 ABC transporter permease -
B4X03_RS05685 1139716..1139970 + 255 WP_021118772.1 hypothetical protein Antitoxin
B4X03_RS05690 1139967..1140251 + 285 WP_010785923.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
B4X03_RS05695 1140462..1142012 + 1551 WP_021114604.1 exodeoxyribonuclease I -
B4X03_RS05700 1142095..1143054 + 960 WP_005712686.1 S-adenosyl-l-methionine hydroxide adenosyltransferase family protein -
B4X03_RS05705 1143203..1144024 + 822 WP_005712684.1 PHP domain-containing protein -
B4X03_RS05710 1144131..1144622 - 492 WP_005712683.1 acetolactate synthase small subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11233.25 Da        Isoelectric Point: 10.5362

>T73995 WP_010785923.1 NZ_CP020085:1139967-1140251 [Glaesserella parasuis]
MSYTIEFIPSAEKEFRKLSLDLRKQFIEKLKERAENPRVESAKLRGMKDCYKIKLRNAGYRLVYQVIDERIVIKVVALGK
RERNDVYQKAQLRL

Download         Length: 285 bp

>T73995 NZ_CP020085:1139967-1140251 [Glaesserella parasuis]
ATGAGCTATACCATTGAATTTATCCCATCAGCAGAAAAAGAGTTTCGTAAACTAAGCTTAGATTTAAGAAAACAATTTAT
CGAAAAACTTAAAGAAAGAGCTGAAAATCCGCGTGTAGAAAGTGCTAAACTTCGTGGAATGAAAGATTGTTATAAAATCA
AATTGCGTAATGCAGGCTATCGTTTGGTGTATCAAGTGATTGATGAACGTATTGTAATCAAAGTGGTTGCACTGGGAAAA
AGGGAGCGCAACGACGTTTACCAAAAAGCACAATTACGTTTATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9347.72 Da        Isoelectric Point: 4.4131

>AT73995 WP_021118772.1 NZ_CP020085:1139716-1139970 [Glaesserella parasuis]
MPSIILTNTVASITELKTNPMATFNAAGGEAIAILNRNEPAFYCVPPHIYEYLIELADDAELAKLVEERQHEKSYKVDLA
DLLK

Download         Length: 255 bp

>AT73995 NZ_CP020085:1139716-1139970 [Glaesserella parasuis]
ATGCCAAGTATTATTTTAACCAATACTGTTGCGAGTATTACAGAGCTAAAGACAAATCCAATGGCGACATTCAATGCGGC
AGGCGGTGAGGCAATTGCAATTTTAAACCGAAATGAACCCGCTTTTTATTGTGTACCACCGCATATTTATGAATATCTCA
TTGAGCTTGCTGATGATGCAGAATTAGCAAAATTAGTGGAAGAACGCCAACACGAAAAAAGCTACAAAGTGGATTTAGCG
GATTTATTAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837AG59

Antitoxin

Source ID Structure
AlphaFold DB A0A837AF96

References