Detailed information of TA system TA073992

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 292821..294370
• Replicon: chromosome
• Accession: NZ_CP020085
• Organism: Glaesserella parasuis strain CL120103

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: B4X03_RS01410
• Protein ID: WP_021114219.1
• Coordinates: 292821..294137 (-)
• Length: 439 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: U4SAZ6
• Locus tag: B4X03_RS01415
• Protein ID: WP_010786623.1
• Coordinates: 294131..294370 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B4X03_RS01390	287868..289673	+	1806	WP_021114223.1	AAA family ATPase	-
B4X03_RS01395	289781..290653	+	873	Protein_265	LysR family transcriptional regulator	-
B4X03_RS01400	290714..291328	-	615	WP_010787298.1	DsbA family protein	-
B4X03_RS11420	291437..291673	+	237	WP_021116421.1	GntR family transcriptional regulator	-
B4X03_RS01405	291681..292817	+	1137	WP_236933862.1	PLP-dependent aminotransferase family protein	-
B4X03_RS01410	292821..294137	-	1317	WP_021114219.1	type II toxin-antitoxin system HipA family toxin	Toxin
B4X03_RS01415	294131..294370	-	240	WP_010786623.1	XRE family transcriptional regulator	Antitoxin
B4X03_RS01420	294518..295345	-	828	WP_021114218.1	alpha/beta hydrolase-fold protein	-
B4X03_RS01425	295476..296921	+	1446	WP_021114217.1	metalloprotease TldD	-
B4X03_RS01430	297175..297585	+	411	WP_010786620.1	preprotein translocase subunit SecE	-
B4X03_RS01435	297587..298165	+	579	WP_020457616.1	transcription termination/antitermination protein NusG	-
B4X03_RS01440	298275..298821	+	547	Protein_275	transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	298275..298745	470

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (5-104)

Antitoxin

• HigA2-like, helix-turn-helix domain (12-66)

Sequences

Toxin

Protein

• Length: 439 a.a.
• Molecular weight: 50015.25 Da
• Isoelectric Point: 7.3465

>T73992 WP_021114219.1 NZ_CP020085:c294137-292821 [Glaesserella parasuis]
MVMRLRVLMNGEMVGYFDRTLSGSHHFTYAESWLNSPLARPISLSMPLQRATYQGKEVINFFDNLLPDNPQIRARIATRF
NAETQQPFDLLAKIGRDAAGAITLLGEDEQIPNHRIIQATELDESEMTKILQSYQYNAPLGMIDNNQDFRISIAGAQEKT
ALLWHNGKWKLPHGLTPTTHIFKLPMGEIRTPKHLLDLSKSVDNELVCLRLFSAFNIPSANVELLEMNDIRALAVERFDR
RLSQDGSYFLRLPYEDFCQAFGLSPTQKYESDGGIGIGDMMNKLLYSSNSNDRRQFMQTQFLFWLLAAIDGHAKNFSLAI
EKQGRYHLSPVYDVISAYPMLGGKGWHHSELQMAMSLRSTQKGKKWHWNKIYAEHFYATAKFVGFSSSDMKQVIEQICDT
VQETIDSVATTLPKQIDENVRDQIFTGIMKQVQKVSMK

Nucleotide

• Length: 1317 bp

>T73992 NZ_CP020085:c294137-292821 [Glaesserella parasuis]
ATGGTAATGCGATTACGAGTATTAATGAATGGCGAAATGGTTGGGTATTTTGACCGCACTTTATCGGGTTCCCACCATTT
TACCTATGCTGAAAGTTGGCTAAATTCCCCATTAGCTCGCCCGATTTCCCTTTCTATGCCCCTGCAAAGAGCAACATATC
AAGGCAAAGAAGTGATTAATTTCTTTGATAATTTACTGCCCGATAATCCTCAAATTCGAGCAAGAATTGCGACAAGATTT
AATGCTGAAACACAACAACCTTTTGACTTACTTGCTAAAATTGGTCGCGATGCTGCGGGTGCTATTACTCTTTTAGGGGA
AGATGAACAAATTCCTAATCATCGAATAATTCAAGCCACAGAATTAGACGAAAGTGAAATGACGAAAATTCTACAAAGTT
ATCAATACAATGCCCCGCTTGGTATGATTGATAATAATCAAGACTTCAGAATTTCTATTGCTGGTGCACAAGAAAAGACA
GCTCTGCTTTGGCATAACGGCAAATGGAAATTACCACACGGATTGACCCCGACAACGCATATTTTCAAATTGCCTATGGG
AGAAATTCGTACCCCTAAACACCTGCTTGATCTGTCAAAAAGTGTAGATAACGAACTCGTCTGTTTGAGATTATTTTCTG
CTTTCAATATCCCTTCCGCAAACGTTGAATTATTGGAAATGAACGATATACGGGCATTAGCTGTTGAACGTTTTGATCGC
CGTCTTAGTCAAGATGGCAGTTATTTTTTACGTTTACCTTACGAAGATTTCTGTCAGGCATTCGGCTTATCGCCAACGCA
AAAATATGAAAGCGATGGTGGAATTGGTATTGGGGATATGATGAATAAGTTGCTCTACTCCAGTAATTCCAACGATCGCC
GTCAATTTATGCAAACTCAATTTCTGTTTTGGCTACTGGCTGCCATTGATGGACACGCTAAAAACTTTTCTCTCGCCATT
GAAAAACAAGGGCGTTATCACTTATCCCCTGTGTATGACGTAATTTCTGCTTATCCAATGTTAGGAGGAAAAGGTTGGCA
TCACAGCGAATTGCAAATGGCAATGAGCTTGCGTAGTACACAAAAAGGGAAAAAATGGCATTGGAATAAAATTTACGCTG
AACATTTCTATGCCACAGCTAAGTTTGTCGGATTTAGCTCAAGTGATATGAAACAAGTGATAGAGCAAATTTGCGATACA
GTGCAAGAAACCATTGATAGCGTAGCAACAACACTACCCAAACAGATAGATGAAAATGTACGGGATCAAATATTCACGGG
CATAATGAAACAGGTGCAAAAAGTTTCTATGAAGTAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9059.47 Da
• Isoelectric Point: 9.7684

>AT73992 WP_010786623.1 NZ_CP020085:c294370-294131 [Glaesserella parasuis]
MLITTPDMLGNSLRDIRKQKKLSQMQIANQVALRQATISTFEKKTDKATIETLFKLLSGLGYELHIQPRPEKTEGNDEW

Nucleotide

• Length: 240 bp

>AT73992 NZ_CP020085:c294370-294131 [Glaesserella parasuis]
ATGTTAATCACGACACCAGATATGCTTGGAAATAGCCTACGCGATATTCGTAAGCAAAAAAAGCTTTCTCAAATGCAAAT
AGCAAATCAAGTAGCTTTAAGACAAGCCACGATTTCCACCTTTGAGAAAAAAACCGATAAAGCCACTATTGAAACATTAT
TCAAGTTACTTTCAGGTTTAGGCTATGAACTACATATCCAACCTCGTCCTGAAAAAACAGAGGGGAATGATGAATGGTAA

Structures

Antitoxin

• AlphaFold DB: U4SAZ6