Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 270248..270854 Replicon chromosome
Accession NZ_CP020085
Organism Glaesserella parasuis strain CL120103

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag B4X03_RS01295 Protein ID WP_021114171.1
Coordinates 270248..270565 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag B4X03_RS01300 Protein ID WP_021114170.1
Coordinates 270567..270854 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B4X03_RS01275 266966..267823 - 858 WP_021114176.1 DUF1837 domain-containing protein -
B4X03_RS11190 267874..268032 - 159 WP_021114175.1 hypothetical protein -
B4X03_RS01280 268204..269004 - 801 WP_021114174.1 efflux RND transporter permease subunit -
B4X03_RS01285 269049..269591 - 543 WP_043896593.1 efflux RND transporter permease subunit -
B4X03_RS01290 269531..270031 - 501 WP_021114172.1 efflux RND transporter permease subunit -
B4X03_RS01295 270248..270565 + 318 WP_021114171.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
B4X03_RS01300 270567..270854 + 288 WP_021114170.1 putative addiction module antidote protein Antitoxin
B4X03_RS11410 271186..271578 - 393 WP_021114169.1 acrA protein -
B4X03_RS11415 271588..272082 - 495 WP_021114168.1 efflux RND transporter periplasmic adaptor subunit -
B4X03_RS01310 272277..273371 - 1095 WP_080651493.1 restriction endonuclease subunit S -
B4X03_RS01315 273392..275434 - 2043 WP_021114165.1 N-6 DNA methylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-95)

Antitoxin

Uncharacterized protein HI1420

(3-89)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11965.65 Da        Isoelectric Point: 9.3816

>T73991 WP_021114171.1 NZ_CP020085:270248-270565 [Glaesserella parasuis]
MNVIETTLIFDEWLDNLKDLRAKIQIVTRIRRAENGNFGDHKPLPNTGGVSEIRLDIGKGYRIYYGQIGEITYILTNGGD
KSSQQADIEKAKALFVQIKQQKKEQ

Download         Length: 318 bp

>T73991 NZ_CP020085:270248-270565 [Glaesserella parasuis]
ATGAACGTCATAGAAACTACGCTTATTTTTGATGAATGGCTTGATAATCTTAAAGATCTAAGGGCTAAAATTCAGATTGT
TACGCGTATCCGCCGTGCTGAAAATGGGAATTTTGGCGATCATAAACCGTTGCCCAACACTGGTGGCGTAAGTGAAATAC
GCTTAGATATTGGAAAAGGTTATCGCATTTATTACGGTCAGATTGGTGAAATCACTTATATTCTCACAAATGGAGGCGAT
AAAAGTAGCCAACAAGCCGATATAGAAAAAGCAAAAGCGTTATTTGTACAGATAAAACAACAGAAAAAGGAACAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10484.04 Da        Isoelectric Point: 5.0489

>AT73991 WP_021114170.1 NZ_CP020085:270567-270854 [Glaesserella parasuis]
MIETNRFDIVKYLDSDEAIAIYLTQIAETGDSNDFIVALGDVARAKGIAEIAQKTGLARESIYKALTSGSKPRFDTIMRI
MNALNLKPQYAINLS

Download         Length: 288 bp

>AT73991 NZ_CP020085:270567-270854 [Glaesserella parasuis]
ATGATTGAAACCAACCGTTTTGATATTGTTAAATACCTAGATAGCGATGAGGCGATTGCCATCTATTTAACTCAAATTGC
AGAAACAGGCGATAGCAATGATTTCATTGTTGCACTTGGTGATGTCGCTCGAGCAAAAGGGATTGCAGAAATCGCACAAA
AAACAGGTCTTGCTCGCGAAAGCATTTATAAAGCTTTAACCAGTGGATCTAAACCACGCTTTGATACCATTATGCGGATT
ATGAATGCACTTAATCTTAAACCGCAATACGCAATCAATTTAAGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References