Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1653943..1654555 Replicon chromosome
Accession NZ_CP020082
Organism Streptococcus pyogenes strain STAB120304

Toxin (Protein)


Gene name parE Uniprot ID Q1JEY4
Locus tag B5D85_RS08705 Protein ID WP_020905490.1
Coordinates 1654220..1654555 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag B5D85_RS08700 Protein ID WP_002988079.1
Coordinates 1653943..1654230 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B5D85_RS08675 1649124..1650107 - 984 WP_020905487.1 tagatose-bisphosphate aldolase -
B5D85_RS08680 1650111..1651040 - 930 WP_076639463.1 tagatose-6-phosphate kinase -
B5D85_RS08685 1651086..1651601 - 516 WP_002988082.1 galactose-6-phosphate isomerase subunit LacB -
B5D85_RS08690 1651636..1652064 - 429 WP_011529004.1 galactose-6-phosphate isomerase subunit LacA -
B5D85_RS08695 1652509..1653282 + 774 WP_011285171.1 DeoR/GlpR family DNA-binding transcription regulator -
B5D85_RS08700 1653943..1654230 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
B5D85_RS08705 1654220..1654555 + 336 WP_020905490.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
B5D85_RS08710 1654707..1654889 + 183 WP_020905491.1 DNA integration/recombination/inversion protein -
B5D85_RS08720 1655321..1655640 + 320 Protein_1612 tyrosine-type recombinase/integrase -
B5D85_RS08725 1655808..1656200 - 393 WP_002982716.1 30S ribosomal protein S9 -
B5D85_RS08730 1656221..1656667 - 447 WP_002982710.1 50S ribosomal protein L13 -
B5D85_RS08735 1656885..1657091 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
B5D85_RS08740 1657088..1657786 - 699 WP_161237464.1 hypothetical protein -
B5D85_RS08745 1657922..1658782 - 861 WP_002982687.1 DegV family protein -
B5D85_RS08750 1658879..1659397 - 519 WP_002982682.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13147.98 Da        Isoelectric Point: 4.9405

>T73986 WP_020905490.1 NZ_CP020082:1654220-1654555 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKIILYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T73986 NZ_CP020082:1654220-1654555 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCATCCTTTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT73986 WP_002988079.1 NZ_CP020082:1653943-1654230 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT73986 NZ_CP020082:1653943-1654230 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q1JEY4

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References