Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-YefM
Location 1520016..1520565 Replicon chromosome
Accession NZ_CP020076
Organism Vibrio campbellii strain 20130629003S01

Toxin (Protein)


Gene name parE Uniprot ID A0A2K7SRW8
Locus tag Vc3S01_RS07745 Protein ID WP_015296889.1
Coordinates 1520016..1520315 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A347UQT2
Locus tag Vc3S01_RS07750 Protein ID WP_005442033.1
Coordinates 1520323..1520565 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Vc3S01_RS07680 1515254..1515766 + 513 WP_077200613.1 hypothetical protein -
Vc3S01_RS07685 1515781..1515873 + 93 WP_199770567.1 DUF3265 domain-containing protein -
Vc3S01_RS07690 1515905..1516531 + 627 WP_077200615.1 hypothetical protein -
Vc3S01_RS07695 1516546..1516638 + 93 WP_077200616.1 DUF3265 domain-containing protein -
Vc3S01_RS07700 1516675..1517100 + 426 WP_077200617.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -
Vc3S01_RS07705 1517248..1517547 + 300 WP_045396921.1 hypothetical protein -
Vc3S01_RS07710 1517544..1517666 + 123 WP_077200618.1 DUF3265 domain-containing protein -
Vc3S01_RS07715 1517696..1518280 + 585 WP_038892789.1 hypothetical protein -
Vc3S01_RS07720 1518307..1518399 + 93 WP_077200619.1 DUF3265 domain-containing protein -
Vc3S01_RS07725 1518380..1518997 + 618 WP_077200620.1 YdcF family protein -
Vc3S01_RS07730 1519012..1519104 + 93 WP_074190183.1 DUF3265 domain-containing protein -
Vc3S01_RS07735 1519148..1519818 + 671 Protein_1401 hypothetical protein -
Vc3S01_RS07740 1519860..1519952 + 93 WP_074050554.1 DUF3265 domain-containing protein -
Vc3S01_RS07745 1520016..1520315 - 300 WP_015296889.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Vc3S01_RS07750 1520323..1520565 - 243 WP_005442033.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
Vc3S01_RS07755 1520679..1520768 + 90 WP_072609597.1 DUF3265 domain-containing protein -
Vc3S01_RS07760 1520925..1521325 + 401 Protein_1406 hypothetical protein -
Vc3S01_RS07765 1521365..1521859 + 495 WP_077200623.1 hypothetical protein -
Vc3S01_RS07770 1522133..1522585 + 453 WP_077200624.1 hypothetical protein -
Vc3S01_RS07775 1522582..1523070 + 489 WP_077200625.1 hypothetical protein -
Vc3S01_RS07780 1523096..1523188 + 93 WP_199770568.1 DUF3265 domain-containing protein -
Vc3S01_RS07785 1523324..1523773 + 450 WP_077200626.1 hypothetical protein -
Vc3S01_RS07790 1524111..1524203 + 93 WP_199770570.1 DUF3265 domain-containing protein -
Vc3S01_RS07795 1524314..1524832 + 519 WP_077200627.1 hypothetical protein -
Vc3S01_RS07800 1524825..1525298 + 474 WP_077200628.1 hypothetical protein -
Vc3S01_RS07805 1525294..1525434 + 141 WP_077200629.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1447573..1538098 90525
- inside Integron - - 1448105..1529246 81141


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-55)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11502.11 Da        Isoelectric Point: 9.3224

>T73985 WP_015296889.1 NZ_CP020076:c1520315-1520016 [Vibrio campbellii]
MQKNKYKLSNLAQSHLRKVKNYTVENFSELQWRNYKDTLLSGFQMLADNPGLGRSCDEIYPNGFYFPIGKHTAYFTKEDD
FILVVAVLGQSQLPQNHLK

Download         Length: 300 bp

>T73985 NZ_CP020076:c1520315-1520016 [Vibrio campbellii]
ATGCAAAAGAACAAATACAAGCTAAGTAACTTAGCACAATCTCACTTGCGCAAGGTCAAAAACTACACTGTTGAAAACTT
TTCTGAATTACAGTGGCGCAACTATAAAGACACTTTGCTATCGGGGTTTCAGATGCTAGCTGATAATCCAGGTTTAGGAA
GAAGTTGTGACGAGATATACCCAAATGGCTTTTATTTTCCGATTGGAAAACACACAGCTTATTTCACCAAAGAAGATGAC
TTTATCTTAGTCGTTGCTGTTTTAGGTCAATCACAACTACCCCAGAATCACCTGAAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9047.26 Da        Isoelectric Point: 5.6926

>AT73985 WP_005442033.1 NZ_CP020076:c1520565-1520323 [Vibrio campbellii]
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDTVVVMSIRDFEELEAMKVEYLKHCFKSAKEDLNNGNTVDGESFLNSL

Download         Length: 243 bp

>AT73985 NZ_CP020076:c1520565-1520323 [Vibrio campbellii]
ATGCATACATTAACAGCCAATGATGCCAAACGAAATTTCGGCGAACTACTTCTAAGCGCACAACGCGAACCAGTAAAAAT
CAGCAAAAACAGTAAAGATACTGTCGTTGTCATGTCCATTCGTGACTTTGAAGAGCTAGAAGCTATGAAAGTTGAGTACC
TCAAACACTGCTTTAAATCAGCCAAAGAAGACTTGAACAATGGGAACACTGTTGATGGCGAAAGCTTTCTAAATTCGCTG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K7SRW8

Antitoxin

Source ID Structure
AlphaFold DB A0A347UQT2

References