Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 1499361..1500127 Replicon chromosome
Accession NZ_CP020076
Organism Vibrio campbellii strain 20130629003S01

Toxin (Protein)


Gene name - Uniprot ID A0A3Q0L5V0
Locus tag Vc3S01_RS07480 Protein ID WP_011080392.1
Coordinates 1499361..1499858 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A3N3DV16
Locus tag Vc3S01_RS07485 Protein ID WP_013571703.1
Coordinates 1499855..1500127 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Vc3S01_RS07405 1494630..1494752 + 123 WP_170926972.1 DUF3265 domain-containing protein -
Vc3S01_RS07410 1494797..1495105 + 309 WP_077200585.1 hypothetical protein -
Vc3S01_RS07415 1495123..1495212 + 90 WP_077201258.1 DUF3265 domain-containing protein -
Vc3S01_RS07420 1495240..1495731 + 492 WP_077200586.1 gamma-glutamylcyclotransferase -
Vc3S01_RS07425 1495746..1495838 + 93 WP_199770609.1 DUF3265 domain-containing protein -
Vc3S01_RS07430 1496293..1496385 + 93 WP_193386937.1 DUF3265 domain-containing protein -
Vc3S01_RS07435 1496393..1496710 - 318 WP_038140554.1 CcdB family protein -
Vc3S01_RS07440 1496710..1496955 - 246 WP_038140558.1 type II toxin-antitoxin system CcdA family antitoxin -
Vc3S01_RS07445 1497030..1497122 + 93 WP_193255160.1 DUF3265 domain-containing protein -
Vc3S01_RS07450 1497159..1497695 + 537 WP_050914845.1 GNAT family N-acetyltransferase -
Vc3S01_RS07455 1497710..1497802 + 93 WP_072605894.1 DUF3265 domain-containing protein -
Vc3S01_RS07460 1497839..1498150 + 312 WP_031850888.1 antibiotic biosynthesis monooxygenase -
Vc3S01_RS07465 1498683..1498775 + 93 WP_170926955.1 DUF3265 domain-containing protein -
Vc3S01_RS07470 1498802..1499209 + 408 WP_038892264.1 hypothetical protein -
Vc3S01_RS07475 1499238..1499327 + 90 WP_077201259.1 DUF3265 domain-containing protein -
Vc3S01_RS07480 1499361..1499858 - 498 WP_011080392.1 GNAT family N-acetyltransferase Toxin
Vc3S01_RS07485 1499855..1500127 - 273 WP_013571703.1 DUF1778 domain-containing protein Antitoxin
Vc3S01_RS31060 1500237..1500329 + 93 WP_086459316.1 DUF3265 domain-containing protein -
Vc3S01_RS07495 1500423..1500842 + 420 WP_077200592.1 hypothetical protein -
Vc3S01_RS07500 1500878..1500970 + 93 WP_212684715.1 DUF3265 domain-containing protein -
Vc3S01_RS07505 1500998..1501370 + 373 Protein_1359 hypothetical protein -
Vc3S01_RS07510 1501392..1501484 + 93 WP_079765598.1 DUF3265 domain-containing protein -
Vc3S01_RS07515 1501513..1501884 + 372 WP_045381734.1 hypothetical protein -
Vc3S01_RS07520 1501911..1502000 + 90 WP_072615095.1 DUF3265 domain-containing protein -
Vc3S01_RS30460 1502120..1502443 + 324 WP_138058874.1 hypothetical protein -
Vc3S01_RS07530 1502471..1502563 + 93 WP_212684710.1 DUF3265 domain-containing protein -
Vc3S01_RS07545 1503052..1503183 + 132 WP_077200598.1 DUF3265 domain-containing protein -
Vc3S01_RS07550 1503214..1503606 + 393 WP_077200599.1 hypothetical protein -
Vc3S01_RS07555 1503624..1503713 + 90 WP_077201261.1 DUF3265 domain-containing protein -
Vc3S01_RS07560 1503750..1504061 + 312 WP_005477810.1 antibiotic biosynthesis monooxygenase -
Vc3S01_RS07565 1504076..1504168 + 93 WP_072833120.1 DUF3265 domain-containing protein -
Vc3S01_RS07570 1504197..1504550 + 354 WP_015296924.1 glyoxalase/bleomycin resistance/dioxygenase family protein -
Vc3S01_RS07575 1504511..1504657 + 147 WP_077201262.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1447573..1538098 90525
- inside Integron - - 1448105..1529246 81141


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18486.13 Da        Isoelectric Point: 8.0487

>T73984 WP_011080392.1 NZ_CP020076:c1499858-1499361 [Vibrio campbellii]
MMNTVLLDKAKHDRNRFNCGIEALNNYLKVMASQQAKKDNTRTFVLEDDNDNSHVIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFEDAENKLFITIADV
RASLG

Download         Length: 498 bp

>T73984 NZ_CP020076:c1499858-1499361 [Vibrio campbellii]
ATGATGAATACGGTACTTCTAGATAAAGCTAAACACGATAGAAACCGATTCAACTGTGGTATCGAAGCTCTCAATAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCAAAAAAAGACAACACCAGAACATTTGTTTTGGAAGATGATAACGACAACTCAC
ATGTCATCGGCTTTTACACGCTAACAATGACACCAATTGACTTAAAGGCATTGCCCGATAAGTTACAAAAAAAACACCAA
TCATCCACCTCTGGTGGTCTGATTGCCCGCCTTGCTGTCGATGACCGATACAAAGGGAAAGGCTTTGGTGAGTGGCTGCT
TATTGACGCACTCAGAAAGCTATTAGCTGCAAGTGATAGCGTTGCATTTCCAGTTGTTATCGTTGATGCCAAAGACGGTG
CGAAACACTTCTATGAACGCTATGGTTTTCAAGCATTTGAAGACGCTGAAAATAAACTCTTCATCACCATTGCTGATGTG
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9747.28 Da        Isoelectric Point: 8.5960

>AT73984 WP_013571703.1 NZ_CP020076:c1500127-1499855 [Vibrio campbellii]
MATTLPRITARVDVDTQDLLTKAAAIAGMSSINSFVLSAAIEKAKQVIEREQALKLSQADAMLLMEALDRPATQNSKLKA
AADRYESKIQ

Download         Length: 273 bp

>AT73984 NZ_CP020076:c1500127-1499855 [Vibrio campbellii]
ATGGCTACTACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACACAAGACTTACTTACTAAGGCTGCCGCGATCGC
CGGTATGTCTAGCATCAACTCGTTCGTTCTAAGCGCTGCAATCGAAAAAGCTAAACAAGTCATCGAACGTGAACAGGCTT
TAAAACTGAGCCAAGCAGATGCGATGTTGCTCATGGAAGCTTTAGACCGTCCTGCAACACAGAACTCAAAACTAAAAGCT
GCTGCTGATCGATACGAGAGCAAAATTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Q0L5V0

Antitoxin

Source ID Structure
AlphaFold DB A0A3N3DV16

References