Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 1471289..1471848 Replicon chromosome
Accession NZ_CP020076
Organism Vibrio campbellii strain 20130629003S01

Toxin (Protein)


Gene name relE Uniprot ID A0A2K7SRU8
Locus tag Vc3S01_RS07110 Protein ID WP_017035198.1
Coordinates 1471289..1471567 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR21
Locus tag Vc3S01_RS07115 Protein ID WP_005398409.1
Coordinates 1471564..1471848 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Vc3S01_RS07050 1466380..1466874 + 495 WP_077200555.1 GNAT family N-acetyltransferase -
Vc3S01_RS07055 1466903..1466995 + 93 WP_005526494.1 DUF3265 domain-containing protein -
Vc3S01_RS07065 1467491..1467625 + 135 WP_086371152.1 DUF3265 domain-containing protein -
Vc3S01_RS07070 1467649..1468383 + 735 WP_082242673.1 hypothetical protein -
Vc3S01_RS07075 1468410..1468502 + 93 WP_079771035.1 DUF3265 domain-containing protein -
Vc3S01_RS07085 1469079..1469510 + 432 WP_077200559.1 hypothetical protein -
Vc3S01_RS07090 1469515..1469625 + 111 WP_077201249.1 DUF3265 domain-containing protein -
Vc3S01_RS07095 1469746..1470183 + 438 WP_077200560.1 DUF2778 domain-containing protein -
Vc3S01_RS07100 1470180..1470524 + 345 WP_050918045.1 hypothetical protein -
Vc3S01_RS07105 1471171..1471260 + 90 WP_077201250.1 DUF3265 domain-containing protein -
Vc3S01_RS07110 1471289..1471567 - 279 WP_017035198.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
Vc3S01_RS07115 1471564..1471848 - 285 WP_005398409.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
Vc3S01_RS07120 1471925..1472029 + 105 WP_114144490.1 DUF3265 domain-containing protein -
Vc3S01_RS07125 1472129..1472407 + 279 WP_077200561.1 hypothetical protein -
Vc3S01_RS07130 1472445..1472537 + 93 WP_078535132.1 DUF3265 domain-containing protein -
Vc3S01_RS07135 1472586..1473086 + 501 WP_038892295.1 hypothetical protein -
Vc3S01_RS07140 1473128..1473217 + 90 WP_077201251.1 DUF3265 domain-containing protein -
Vc3S01_RS07145 1473244..1473690 + 447 WP_077200563.1 GNAT family N-acetyltransferase -
Vc3S01_RS07150 1473834..1474580 + 747 WP_077200564.1 hypothetical protein -
Vc3S01_RS07155 1474595..1474687 + 93 WP_004748931.1 DUF3265 domain-containing protein -
Vc3S01_RS07165 1475021..1475131 + 111 WP_077201252.1 DUF3265 domain-containing protein -
Vc3S01_RS07170 1475168..1475500 + 333 WP_009387531.1 hypothetical protein -
Vc3S01_RS07175 1475518..1475607 + 90 WP_075984317.1 DUF3265 domain-containing protein -
Vc3S01_RS07180 1476053..1476142 + 90 WP_072615095.1 DUF3265 domain-containing protein -
Vc3S01_RS07185 1476294..1476710 + 417 WP_077200567.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1447573..1538098 90525
- inside Integron - - 1448105..1529246 81141


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10905.60 Da        Isoelectric Point: 4.3430

>T73983 WP_017035198.1 NZ_CP020076:c1471567-1471289 [Vibrio campbellii]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWIEGDIIRVM
RVLHQKQKFPTD

Download         Length: 279 bp

>T73983 NZ_CP020076:c1471567-1471289 [Vibrio campbellii]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTTGAGTTTCTCTATGACTTCAACCCTGATGCTGC
AGAAAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGTGTGCAACGAGATGGCA
TCCGTGGACGATTACTCATCATTCCTGAGATTTCGATGATTGTCTCTTACTGGATTGAGGGCGATATCATCCGAGTTATG
CGTGTACTGCACCAGAAACAAAAATTCCCTACGGATTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11069.40 Da        Isoelectric Point: 9.2167

>AT73983 WP_005398409.1 NZ_CP020076:c1471848-1471564 [Vibrio campbellii]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ

Download         Length: 285 bp

>AT73983 NZ_CP020076:c1471848-1471564 [Vibrio campbellii]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGCAC
TCTGAGTGACGCATGTCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAAACATTATCTCACGATGCATGGCTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAATCCGTTTTCGTTGAGCACCAAACGGCTAAGTCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K7SRU8

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR21

References