Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 1450879..1451426 Replicon chromosome
Accession NZ_CP020076
Organism Vibrio campbellii strain 20130629003S01

Toxin (Protein)


Gene name relE Uniprot ID A0A240EQK2
Locus tag Vc3S01_RS06905 Protein ID WP_012128216.1
Coordinates 1451124..1451426 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A7MSI1
Locus tag Vc3S01_RS06900 Protein ID WP_012128217.1
Coordinates 1450879..1451136 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Vc3S01_RS06865 1446387..1446971 + 585 WP_038890023.1 ribosomal protein S5-alanine N-acetyltransferase -
Vc3S01_RS06870 1446972..1447559 + 588 WP_077200536.1 HD domain-containing protein -
Vc3S01_RS06875 1447573..1448046 + 474 WP_005434054.1 DUF2947 domain-containing protein -
Vc3S01_RS06880 1448105..1449067 - 963 WP_045369120.1 integron integrase -
Vc3S01_RS06885 1449309..1450070 + 762 WP_077200537.1 FRG domain-containing protein -
Vc3S01_RS06895 1450666..1450797 + 132 WP_077200539.1 DUF3265 domain-containing protein -
Vc3S01_RS06900 1450879..1451136 + 258 WP_012128217.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
Vc3S01_RS06905 1451124..1451426 + 303 WP_012128216.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Vc3S01_RS06910 1451465..1451554 + 90 WP_072036466.1 DUF3265 domain-containing protein -
Vc3S01_RS06915 1452075..1452164 + 90 WP_075111252.1 DUF3265 domain-containing protein -
Vc3S01_RS06920 1452204..1452611 + 408 WP_017191323.1 hypothetical protein -
Vc3S01_RS06925 1452671..1452763 + 93 WP_079386191.1 DUF3265 domain-containing protein -
Vc3S01_RS06930 1452796..1453356 + 561 WP_077200540.1 hypothetical protein -
Vc3S01_RS06935 1453672..1454028 + 357 WP_077201243.1 hypothetical protein -
Vc3S01_RS06940 1454043..1454135 + 93 WP_072600995.1 DUF3265 domain-containing protein -
Vc3S01_RS06945 1454173..1454613 + 441 WP_077200541.1 hypothetical protein -
Vc3S01_RS06950 1454610..1454720 + 111 WP_077201244.1 DUF3265 domain-containing protein -
Vc3S01_RS06955 1454748..1455821 + 1074 WP_077200542.1 hypothetical protein -
Vc3S01_RS31045 1455836..1455928 + 93 WP_077200543.1 DUF3265 domain-containing protein -
Vc3S01_RS06965 1455955..1456401 + 447 WP_077200544.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1447573..1538098 90525
- inside Integron - - 1448105..1529246 81141


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11699.59 Da        Isoelectric Point: 5.1765

>T73982 WP_012128216.1 NZ_CP020076:1451124-1451426 [Vibrio campbellii]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQDSDKV
FILFVMRAERDLRKFLLSKQ

Download         Length: 303 bp

>T73982 NZ_CP020076:1451124-1451426 [Vibrio campbellii]
ATGGCTGAAATAATCTGGACTGAGCCAGCGTTATCAGACCTCAACGATATCGCTGAATACATCGCACTTGAAAATATCGT
AGCTGCAAAGCAGTTAGTGCAAACGATCTTCTCCAAAGTCGAACGCCTACAAACTTTCCCAGAGTCAGGTCGTATTCCAC
CCGAGCTAGAACATTTAAGTTATCGTGAAGTTGTCGTTAATCCATGTCGTGTTTTCTATAAACAAGACAGTGACAAAGTG
TTTATTCTGTTTGTTATGCGTGCAGAGAGAGATTTACGTAAGTTCTTGTTGAGTAAGCAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9548.06 Da        Isoelectric Point: 7.3177

>AT73982 WP_012128217.1 NZ_CP020076:1450879-1451136 [Vibrio campbellii]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALAGGKVVSHDEAKDKM
SKWLK

Download         Length: 258 bp

>AT73982 NZ_CP020076:1450879-1451136 [Vibrio campbellii]
ATGAAAGTAGAACTAGTTACATCACTCAAGCGTCAAGCAACTAAGATCCTCGCCGATCTCCACGACACCAAAGAACCAGT
GTTAATTACTGAGCATGGTAAGCCATCCGCGTATCTCGTTGATGTTGATGACTACGAGTTTATGCAAAATCGTTTAGCTA
TTCTTGAGGGTATTGCACGAGGTGAGCGTGCACTAGCTGGCGGTAAAGTGGTAAGTCATGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A240EQK2

Antitoxin

Source ID Structure
AlphaFold DB A7MSI1

References