Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1832615..1833131 Replicon chromosome
Accession NZ_CP020071
Organism Klebsiella pneumoniae strain AR_0115

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag AM362_RS09375 Protein ID WP_002886902.1
Coordinates 1832847..1833131 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag AM362_RS09370 Protein ID WP_002886901.1
Coordinates 1832615..1832857 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM362_RS09355 1828644..1829384 + 741 WP_002886899.1 KDGP aldolase family protein -
AM362_RS09360 1829450..1830604 + 1155 WP_002886900.1 lactonase family protein -
AM362_RS09365 1830627..1832537 + 1911 WP_004152270.1 BglG family transcription antiterminator -
AM362_RS09370 1832615..1832857 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
AM362_RS09375 1832847..1833131 + 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AM362_RS09380 1833135..1833599 - 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
AM362_RS09385 1833840..1835978 - 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
AM362_RS09390 1836335..1837078 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
AM362_RS29480 1837081..1837254 - 174 WP_002886906.1 hypothetical protein -
AM362_RS09395 1837339..1837647 + 309 WP_002886907.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T73968 WP_002886902.1 NZ_CP020071:1832847-1833131 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T73968 NZ_CP020071:1832847-1833131 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT73968 WP_002886901.1 NZ_CP020071:1832615-1832857 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT73968 NZ_CP020071:1832615-1832857 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References