Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/ElaA-DUF1778
Location 215457..216208 Replicon plasmid unitig_1
Accession NZ_CP020068
Organism Klebsiella pneumoniae strain AR_0068

Toxin (Protein)


Gene name ataT Uniprot ID H6U1U8
Locus tag AM447_RS27715 Protein ID WP_014386536.1
Coordinates 215457..215939 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A071LPN3
Locus tag AM447_RS27720 Protein ID WP_004902250.1
Coordinates 215930..216208 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM447_RS27690 211856..212503 - 648 WP_014386537.1 EcsC family protein -
AM447_RS27695 212530..213285 - 756 WP_004902235.1 DUF2971 domain-containing protein -
AM447_RS31220 213386..213778 - 393 WP_032442757.1 hypothetical protein -
AM447_RS27700 213883..214422 - 540 WP_004902239.1 hypothetical protein -
AM447_RS27715 215457..215939 - 483 WP_014386536.1 GNAT family N-acetyltransferase Toxin
AM447_RS27720 215930..216208 - 279 WP_004902250.1 DUF1778 domain-containing protein Antitoxin
AM447_RS27725 216327..216539 - 213 WP_004902255.1 hypothetical protein -
AM447_RS27730 216647..216988 - 342 WP_004902257.1 hypothetical protein -
AM447_RS27740 217818..218276 - 459 WP_014386535.1 hypothetical protein -
AM447_RS27745 218929..219384 - 456 WP_001166628.1 Hg(II)-responsive transcriptional regulator -
AM447_RS27750 219456..219821 + 366 WP_004200999.1 mercuric ion transporter MerT -
AM447_RS27755 219837..220112 + 276 WP_000732275.1 mercury resistance system periplasmic binding protein MerP -
AM447_RS27760 220140..220565 + 426 WP_000522996.1 organomercurial transporter MerC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid sul2 / aph(3'')-Ib / aph(6)-Id / blaSHV-187 / aac(3)-IId / blaNDM-1 / aph(3')-VI / mph(E) / msr(E) / armA / sul1 / qacE / aadA2 / dfrA12 - 1..276460 276460


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(10-86)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17662.45 Da        Isoelectric Point: 8.9130

>T73959 WP_014386536.1 NZ_CP020068:c215939-215457 [Klebsiella pneumoniae]
MGMRAPESLTAEHNIAEFCCQEPALNEWLKKKALRNHSTGISRVYVVCAENTNRVIGYYCLSSGSVHRNTVPGAYRRNAP
DVIPVIVLGRLAIDQAWAGNGLGAALLKDAIYRTQNIAFQVGVRALAVHALNEEVKCFYTRFGFEPSIVNTLTLLFPIKV

Download         Length: 483 bp

>T73959 NZ_CP020068:c215939-215457 [Klebsiella pneumoniae]
ATGGGAATGAGAGCGCCTGAATCCCTGACGGCTGAACATAACATCGCTGAGTTCTGCTGCCAGGAGCCTGCCCTTAATGA
GTGGTTAAAGAAGAAGGCTCTCAGAAACCACAGTACCGGCATTTCCCGTGTCTATGTCGTCTGCGCAGAAAACACTAACC
GGGTCATCGGTTATTATTGTTTATCTTCGGGTAGCGTCCACCGTAACACAGTGCCTGGGGCCTATAGACGCAACGCGCCT
GATGTCATTCCAGTCATTGTTTTGGGACGGCTTGCCATCGACCAGGCCTGGGCCGGGAATGGGCTTGGTGCCGCACTTCT
TAAGGATGCTATATACCGTACGCAAAACATAGCCTTTCAGGTCGGGGTGAGAGCACTGGCCGTGCATGCGCTGAATGAAG
AAGTTAAATGTTTTTACACCCGTTTTGGCTTTGAGCCTTCCATAGTCAACACGCTGACATTGTTATTCCCGATAAAAGTC
TGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10704.23 Da        Isoelectric Point: 4.5271

>AT73959 WP_004902250.1 NZ_CP020068:c216208-215930 [Klebsiella pneumoniae]
MKPDVREAPINIRAKTSQRDLIDMAASLVSKSRTDFMLEVACREAQDILLDQRLFLLNDNQFEAFIEELDAPITPERQAR
IDNLMNRKSPWE

Download         Length: 279 bp

>AT73959 NZ_CP020068:c216208-215930 [Klebsiella pneumoniae]
ATGAAACCAGACGTTCGTGAAGCTCCGATTAATATCCGGGCCAAAACATCACAGCGTGACCTGATCGACATGGCCGCAAG
CCTGGTCTCAAAATCACGGACTGATTTTATGCTTGAGGTTGCCTGCAGGGAGGCACAGGACATTCTGCTTGATCAACGCC
TGTTCCTCCTCAATGACAATCAGTTTGAGGCGTTTATTGAAGAGCTTGACGCCCCAATAACGCCGGAGCGCCAGGCGCGA
ATCGATAACCTGATGAACCGCAAATCACCATGGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MBI1

Antitoxin

Source ID Structure
AlphaFold DB A0A071LPN3

References