Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yeeU/CbtA-CbeA
Location 3759520..3760246 Replicon chromosome
Accession NZ_CP020061
Organism Klebsiella pneumoniae strain AR_0117

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag AM364_RS18320 Protein ID WP_048997683.1
Coordinates 3759520..3759861 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag AM364_RS18325 Protein ID WP_004129347.1
Coordinates 3759896..3760246 (-) Length 117 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM364_RS18300 3755028..3755294 + 267 WP_004178415.1 hypothetical protein -
AM364_RS18305 3755294..3755993 + 700 Protein_3511 DUF4400 domain-containing protein -
AM364_RS18310 3756228..3757715 + 1488 WP_048997682.1 hypothetical protein -
AM364_RS18320 3759520..3759861 - 342 WP_048997683.1 TA system toxin CbtA family protein Toxin
AM364_RS18325 3759896..3760246 - 351 WP_004129347.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
AM364_RS18330 3760267..3760488 - 222 WP_004129348.1 DUF987 domain-containing protein -
AM364_RS18335 3760504..3760977 - 474 WP_004129349.1 DNA repair protein RadC -
AM364_RS18340 3761048..3761869 - 822 WP_045334523.1 DUF945 domain-containing protein -
AM364_RS18345 3761965..3762642 - 678 WP_080031156.1 hypothetical protein -
AM364_RS18350 3762928..3763821 - 894 WP_004129354.1 50S ribosome-binding GTPase -
AM364_RS29435 3763919..3765070 + 1152 WP_128973363.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3740939..3787713 46774


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(15-115)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12933.00 Da        Isoelectric Point: 5.5941

>T73933 WP_048997683.1 NZ_CP020061:c3759861-3759520 [Klebsiella pneumoniae]
MNTLPAINQRAIQLCPSPVTIWQTLLTRLLEQHYGLALNDTPFGDESVIQEHIEAGITLVDAVNFLVEKYELVRIDRWAF
GWLEPSPYLRAVDILRMRRDMGLLRGCNHTAAM

Download         Length: 342 bp

>T73933 NZ_CP020061:c3759861-3759520 [Klebsiella pneumoniae]
ATGAATACTTTACCTGCAATAAACCAGCGGGCTATTCAGTTATGCCCATCGCCTGTAACTATCTGGCAAACGTTGCTAAC
TCGTTTACTGGAACAACACTACGGGCTGGCGCTGAACGACACACCGTTCGGTGATGAAAGCGTGATTCAGGAACATATCG
AGGCCGGTATTACACTCGTTGATGCCGTTAACTTCTTGGTGGAAAAGTACGAGCTGGTTCGTATCGACCGCTGGGCGTTT
GGCTGGTTGGAACCATCTCCATACTTGCGAGCTGTAGACATTCTGCGAATGCGTCGGGACATGGGGCTGTTGCGAGGCTG
CAACCACACTGCAGCAATGTGA

Antitoxin


Download         Length: 117 a.a.        Molecular weight: 12956.70 Da        Isoelectric Point: 6.9559

>AT73933 WP_004129347.1 NZ_CP020061:c3760246-3759896 [Klebsiella pneumoniae]
MSSKTLTVNDDTAEPWWGLNRNVIPCFGARLVQEGNRLHYLSDRASITGQFNKADLLHLDQAFPVLLKQAELMLTSGELN
PRHQHSVTLYAKGLTCEADTLGSCGHVYISIYPTQR

Download         Length: 351 bp

>AT73933 NZ_CP020061:c3760246-3759896 [Klebsiella pneumoniae]
ATGTCGAGTAAGACACTCACTGTGAATGATGATACAGCTGAGCCCTGGTGGGGGCTGAATCGTAATGTCATTCCTTGTTT
TGGTGCACGTCTGGTCCAGGAAGGTAACCGCCTACATTACCTGTCTGACCGCGCCAGCATAACAGGTCAGTTCAATAAAG
CGGATTTGCTCCATCTTGACCAGGCATTTCCTGTTCTGCTGAAGCAGGCGGAGCTCATGCTTACCAGCGGCGAACTGAAT
CCCCGACACCAGCATAGCGTCACCCTCTATGCAAAGGGGTTGACCTGTGAAGCTGATACGCTGGGTTCCTGTGGTCACGT
CTATATCTCCATTTATCCTACTCAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References