Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3933991..3934786 Replicon chromosome
Accession NZ_CP020055
Organism Escherichia coli strain AR_0069

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag AM448_RS20080 Protein ID WP_000854914.1
Coordinates 3934412..3934786 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B7UP42
Locus tag AM448_RS20075 Protein ID WP_001280955.1
Coordinates 3933991..3934365 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM448_RS20035 3930251..3930663 - 413 Protein_3644 hypothetical protein -
AM448_RS20040 3930877..3931527 - 651 Protein_3645 IS110-like element ISEc20 family transposase -
AM448_RS20045 3931524..3932141 + 618 Protein_3646 AIDA repeat-containing protein -
AM448_RS20050 3932141..3932476 + 336 Protein_3647 DUF932 domain-containing protein -
AM448_RS20055 3932567..3933052 + 486 WP_000214398.1 antirestriction protein -
AM448_RS20060 3933068..3933544 + 477 WP_001186738.1 RadC family protein -
AM448_RS20065 3933607..3933828 + 222 WP_001220314.1 DUF987 domain-containing protein -
AM448_RS20075 3933991..3934365 + 375 WP_001280955.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
AM448_RS20080 3934412..3934786 + 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
AM448_RS20085 3934783..3935274 + 492 WP_000976857.1 hypothetical protein -
AM448_RS20090 3935286..3935483 + 198 WP_000839282.1 DUF957 domain-containing protein -
AM448_RS20095 3935568..3936410 + 843 WP_001280481.1 DUF4942 domain-containing protein -
AM448_RS20105 3936881..3937819 + 939 WP_080028866.1 glyoxylate/hydroxypyruvate reductase GhrA -
AM448_RS20110 3937874..3938611 + 738 WP_000283664.1 zinc-binding phosphatase -
AM448_RS20115 3938635..3939189 + 555 WP_001001902.1 molecular chaperone YcdY -
AM448_RS20120 3939291..3939782 + 492 WP_001297187.1 DUF1097 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T73895 WP_000854914.1 NZ_CP020055:3934412-3934786 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T73895 NZ_CP020055:3934412-3934786 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13767.59 Da        Isoelectric Point: 6.6248

>AT73895 WP_001280955.1 NZ_CP020055:3933991-3934365 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT73895 NZ_CP020055:3933991-3934365 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9P0D0

References