Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 2747025..2747601 Replicon chromosome
Accession NZ_CP020055
Organism Escherichia coli strain AR_0069

Toxin (Protein)


Gene name shpA Uniprot ID D3GXZ2
Locus tag AM448_RS14085 Protein ID WP_001297643.1
Coordinates 2747025..2747312 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A829G8Z0
Locus tag AM448_RS14090 Protein ID WP_000063156.1
Coordinates 2747299..2747601 (+) Length 101 a.a.

Genomic Context


AM448_RS14080AM448_RS14085AM448_RS14090AM448_RS14070AM448_RS14075AM448_RS14095AM448_RS14100AM448_RS14105
Location: 2746129..2746826 (698 bp)
Type: Others
Protein ID: Protein_2567
Location: 2747025..2747312 (288 bp)
Type: Toxin
Protein ID: WP_001297643.1
Location: 2747299..2747601 (303 bp)
Type: Antitoxin
Protein ID: WP_000063156.1
Location: 2743250..2744530 (1281 bp)
Type: Others
Protein ID: WP_016230805.1
Location: 2744571..2745803 (1233 bp)
Type: Others
Protein ID: WP_016230806.1
Location: 2747635..2748591 (957 bp)
Type: Others
Protein ID: WP_001393094.1
Location: 2748602..2748805 (204 bp)
Type: Others
Protein ID: WP_000467859.1
Location: 2748855..2751005 (2151 bp)
Type: Others
Protein ID: WP_001295524.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
AM448_RS140702743250..2744530-1281WP_016230805.1DUF445 domain-containing protein-
AM448_RS140752744571..2745803-1233WP_016230806.1multidrug efflux MFS transporter MdtM-
AM448_RS140802746129..2746826+698Protein_2567IS1 family transposase-
AM448_RS140852747025..2747312+288WP_001297643.1BrnT family toxinToxin
AM448_RS140902747299..2747601+303WP_000063156.1BrnA antitoxin family proteinAntitoxin
AM448_RS140952747635..2748591-957WP_001393094.1GTPase-
AM448_RS141002748602..2748805-204WP_000467859.1YbdD/YjiX family protein-
AM448_RS141052748855..2751005-2151WP_001295524.1pyruvate/proton symporter BtsT-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-flankIS/Tn--2746533..2746826293


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11295.77 Da        Isoelectric Point: 6.8821

>T73893 WP_001297643.1 NZ_CP020055:2747025-2747312 [Escherichia coli]
MPMEFEWDENKAKSNRVKHGIRFEDAVLLFDDPQHLSQQERIENGEYRWQTIGLVYGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

>T73893 NZ_CP020055:2747025-2747312 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11521.99 Da        Isoelectric Point: 9.4646

>AT73893 WP_000063156.1 NZ_CP020055:2747299-2747601 [Escherichia coli]
MSMVKHKRGTSSTLDVQHEAELKALANKSDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp

>AT73893 NZ_CP020055:2747299-2747601 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGGCGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A829GEV9


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A829G8Z0

References