Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | shpAB/BrnT-BrnA |
Location | 2747025..2747601 | Replicon | chromosome |
Accession | NZ_CP020055 | ||
Organism | Escherichia coli strain AR_0069 |
Toxin (Protein)
Gene name | shpA | Uniprot ID | D3GXZ2 |
Locus tag | AM448_RS14085 | Protein ID | WP_001297643.1 |
Coordinates | 2747025..2747312 (+) | Length | 96 a.a. |
Antitoxin (Protein)
Gene name | shpB | Uniprot ID | A0A829G8Z0 |
Locus tag | AM448_RS14090 | Protein ID | WP_000063156.1 |
Coordinates | 2747299..2747601 (+) | Length | 101 a.a. |
Genomic Context
Location: 2746129..2746826 (698 bp)
Type: Others
Protein ID: Protein_2567
Type: Others
Protein ID: Protein_2567
Location: 2747025..2747312 (288 bp)
Type: Toxin
Protein ID: WP_001297643.1
Type: Toxin
Protein ID: WP_001297643.1
Location: 2747299..2747601 (303 bp)
Type: Antitoxin
Protein ID: WP_000063156.1
Type: Antitoxin
Protein ID: WP_000063156.1
Location: 2743250..2744530 (1281 bp)
Type: Others
Protein ID: WP_016230805.1
Type: Others
Protein ID: WP_016230805.1
Location: 2744571..2745803 (1233 bp)
Type: Others
Protein ID: WP_016230806.1
Type: Others
Protein ID: WP_016230806.1
Location: 2747635..2748591 (957 bp)
Type: Others
Protein ID: WP_001393094.1
Type: Others
Protein ID: WP_001393094.1
Location: 2748602..2748805 (204 bp)
Type: Others
Protein ID: WP_000467859.1
Type: Others
Protein ID: WP_000467859.1
Location: 2748855..2751005 (2151 bp)
Type: Others
Protein ID: WP_001295524.1
Type: Others
Protein ID: WP_001295524.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
AM448_RS14070 | 2743250..2744530 | - | 1281 | WP_016230805.1 | DUF445 domain-containing protein | - |
AM448_RS14075 | 2744571..2745803 | - | 1233 | WP_016230806.1 | multidrug efflux MFS transporter MdtM | - |
AM448_RS14080 | 2746129..2746826 | + | 698 | Protein_2567 | IS1 family transposase | - |
AM448_RS14085 | 2747025..2747312 | + | 288 | WP_001297643.1 | BrnT family toxin | Toxin |
AM448_RS14090 | 2747299..2747601 | + | 303 | WP_000063156.1 | BrnA antitoxin family protein | Antitoxin |
AM448_RS14095 | 2747635..2748591 | - | 957 | WP_001393094.1 | GTPase | - |
AM448_RS14100 | 2748602..2748805 | - | 204 | WP_000467859.1 | YbdD/YjiX family protein | - |
AM448_RS14105 | 2748855..2751005 | - | 2151 | WP_001295524.1 | pyruvate/proton symporter BtsT | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | flank | IS/Tn | - | - | 2746533..2746826 | 293 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11295.77 Da Isoelectric Point: 6.8821
>T73893 WP_001297643.1 NZ_CP020055:2747025-2747312 [Escherichia coli]
MPMEFEWDENKAKSNRVKHGIRFEDAVLLFDDPQHLSQQERIENGEYRWQTIGLVYGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERNRYEHG
MPMEFEWDENKAKSNRVKHGIRFEDAVLLFDDPQHLSQQERIENGEYRWQTIGLVYGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERNRYEHG
Download Length: 288 bp
>T73893 NZ_CP020055:2747025-2747312 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11521.99 Da Isoelectric Point: 9.4646
>AT73893 WP_000063156.1 NZ_CP020055:2747299-2747601 [Escherichia coli]
MSMVKHKRGTSSTLDVQHEAELKALANKSDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK
MSMVKHKRGTSSTLDVQHEAELKALANKSDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK
Download Length: 303 bp
>AT73893 NZ_CP020055:2747299-2747601 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGGCGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGGCGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA
Structures
Toxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829GEV9 |
Antitoxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829G8Z0 |