Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 2173348..2173944 Replicon chromosome
Accession NZ_CP020053
Organism Enterobacter cloacae complex sp. strain AR_0065

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag AM444_RS10705 Protein ID WP_023295756.1
Coordinates 2173348..2173650 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A927HL08
Locus tag AM444_RS10710 Protein ID WP_023295755.1
Coordinates 2173657..2173944 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM444_RS10685 (AM444_10770) 2169567..2170916 + 1350 WP_006810501.1 lysine-sensitive aspartokinase 3 -
AM444_RS10690 (AM444_10775) 2171010..2171954 + 945 WP_023295757.1 ketopantoate/pantoate/pantothenate transporter PanS -
AM444_RS10695 (AM444_10780) 2172005..2172277 + 273 WP_017382612.1 DUF3811 domain-containing protein -
AM444_RS10700 (AM444_10785) 2172278..2173150 - 873 WP_003860347.1 23S rRNA pseudouridine(2604) synthase RluF -
AM444_RS10705 (AM444_10790) 2173348..2173650 + 303 WP_023295756.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AM444_RS10710 (AM444_10795) 2173657..2173944 + 288 WP_023295755.1 putative addiction module antidote protein Antitoxin
AM444_RS10715 (AM444_10800) 2173941..2175572 - 1632 WP_032104798.1 Na/Pi cotransporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-93)

Antitoxin

Uncharacterized protein HI1420

(3-90)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11441.24 Da        Isoelectric Point: 10.1042

>T73866 WP_023295756.1 NZ_CP020053:2173348-2173650 [Enterobacter cloacae complex sp.]
MKEIVQTESFRRWEQNLKDRRAKTIIASRLFRLANGLAGDIRPVGEGISELRIHFGPGYRIYFKDQGNCIIVLLCGGDKS
SQARDILMAKMLSNVSQWQE

Download         Length: 303 bp

>T73866 NZ_CP020053:2173348-2173650 [Enterobacter cloacae complex sp.]
ATGAAGGAGATCGTTCAGACAGAATCCTTCCGACGCTGGGAGCAAAATTTAAAGGACAGGCGGGCAAAGACGATTATCGC
CTCCCGCCTCTTTAGGCTGGCAAATGGCTTAGCGGGCGACATTAGACCTGTGGGAGAAGGTATCAGTGAACTGAGGATCC
ACTTTGGCCCGGGCTACAGGATCTATTTTAAGGACCAGGGCAATTGCATCATCGTGCTGTTATGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTTATGGCAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10101.59 Da        Isoelectric Point: 5.7807

>AT73866 WP_023295755.1 NZ_CP020053:2173657-2173944 [Enterobacter cloacae complex sp.]
MHKLTPYDPANALLDDEEIAVFMADALETGDSAYIAKALGVIARAKGMSTISQQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGLGLTIKPSGD

Download         Length: 288 bp

>AT73866 NZ_CP020053:2173657-2173944 [Enterobacter cloacae complex sp.]
ATGCATAAATTAACACCCTACGATCCAGCCAACGCACTGCTGGATGACGAGGAAATCGCTGTGTTTATGGCTGATGCATT
AGAGACGGGTGACTCAGCGTACATTGCTAAAGCGCTGGGCGTCATCGCCCGAGCGAAAGGGATGTCGACCATTTCCCAGC
AAACGGGCCTGTCACGAGAACAACTGTATCGATCATTCAGTGATAAGGGGAACCCAACGCTCAAAACCACGCTGGCGGTC
ATGAAAGCATTGGGCCTTGGGTTAACAATCAAACCCTCTGGGGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References