Detailed information of TA system TA073862

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3799398..3800043
• Replicon: chromosome
• Accession: NZ_CP020052
• Organism: Proteus mirabilis strain AR_0059

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: B4ET86
• Locus tag: AM438_RS17820
• Protein ID: WP_004247035.1
• Coordinates: 3799398..3799583 (+)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: B4ET85
• Locus tag: AM438_RS17825
• Protein ID: WP_004247034.1
• Coordinates: 3799630..3800043 (+)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AM438_RS17795	3796175..3796426	+	252	WP_049212512.1	hypothetical protein	-
AM438_RS17800	3796485..3797054	+	570	WP_080047858.1	serine acetyltransferase	-
AM438_RS20065	3797125..3797421	+	297	Protein_3421	glycosyltransferase	-
AM438_RS20070	3797476..3797916	+	441	WP_196220051.1	hypothetical protein	-
AM438_RS17815	3798517..3799287	-	771	Protein_3423	DUF1073 domain-containing protein	-
AM438_RS17820	3799398..3799583	+	186	WP_004247035.1	type II toxin-antitoxin system HicA family toxin	Toxin
AM438_RS17825	3799630..3800043	+	414	WP_004247034.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
AM438_RS17830	3800139..3800639	+	501	WP_004247032.1	response regulator	-
AM438_RS17835	3800953..3801246	+	294	Protein_3427	LysE family transporter	-
AM438_RS17840	3801359..3801937	-	579	WP_004247030.1	alpha/beta hydrolase	-
AM438_RS17850	3802581..3803327	+	747	WP_049212369.1	class I SAM-dependent methyltransferase	-
AM438_RS20075	3803496..3803672	-	177	WP_004247793.1	hypothetical protein	-
AM438_RS20080	3804124..3804282	+	159	WP_004247025.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 7049.30 Da
• Isoelectric Point: 10.9659

>T73862 WP_004247035.1 NZ_CP020052:3799398-3799583 [Proteus mirabilis]
MKSSELIKLLEKNGWILDRIKGSHHQFTHPDFSFVVTVPHPRKDLKKGTLNQIIKSAKLKN

Nucleotide

• Length: 186 bp

>T73862 NZ_CP020052:3799398-3799583 [Proteus mirabilis]
TTGAAAAGTTCGGAACTGATTAAGTTGTTAGAAAAAAACGGATGGATACTTGATAGAATAAAAGGAAGTCATCATCAATT
TACTCACCCTGATTTTTCTTTTGTTGTAACAGTACCGCATCCAAGAAAAGATTTAAAAAAAGGAACATTAAATCAAATTA
TTAAAAGTGCCAAACTGAAAAATTAA

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 15251.98 Da
• Isoelectric Point: 4.3830

>AT73862 WP_004247034.1 NZ_CP020052:3799630-3800043 [Proteus mirabilis]
MLYPAFIEIDEDGSASGWFPDIDGCIFAGDSIEEAHADARSAIDAHFELLSEKGLDIPSPKSQQEHLINSSGDYNNGIWL
LVDVDMDKYDGRAERINITLPHRLLSRIDTIVKTNPEYGSRSGFIATATRKELQKNI

Nucleotide

• Length: 414 bp

>AT73862 NZ_CP020052:3799630-3800043 [Proteus mirabilis]
ATGTTATATCCAGCCTTTATTGAAATTGATGAAGATGGTAGCGCAAGTGGCTGGTTCCCTGATATTGATGGTTGCATCTT
TGCGGGGGACAGTATTGAAGAAGCTCACGCAGATGCGAGGAGCGCTATTGATGCCCATTTTGAATTGTTAAGCGAGAAGG
GTTTAGATATCCCCTCTCCAAAATCTCAACAAGAGCATTTAATTAATTCTAGTGGTGATTACAATAATGGAATATGGCTT
TTAGTTGATGTTGATATGGATAAATACGACGGACGAGCAGAGCGTATTAATATCACATTGCCACATCGATTATTGAGTCG
CATCGATACTATCGTAAAAACAAATCCTGAATATGGGAGTCGTAGCGGATTTATTGCCACAGCAACCCGTAAAGAACTCC
AAAAGAATATTTAA

Structures

Toxin

• AlphaFold DB: B4ET86

Antitoxin

• AlphaFold DB: B4ET85