73860

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-MqsA
Location 1543458..1544157 Replicon chromosome
Accession NZ_CP020052
Organism Proteus mirabilis strain AR_0059

Toxin (Protein)


Gene name relE Uniprot ID B4EZ96
Locus tag AM438_RS07210 Protein ID WP_004249093.1
Coordinates 1543771..1544157 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B4EZ97
Locus tag AM438_RS07205 Protein ID WP_004246828.1
Coordinates 1543458..1543778 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM438_RS07175 1538590..1538865 - 276 WP_004246820.1 DNA-directed RNA polymerase subunit omega -
AM438_RS07180 1538920..1539543 - 624 WP_049211625.1 guanylate kinase -
AM438_RS07185 1539845..1540462 - 618 WP_004246822.1 trimeric intracellular cation channel family protein -
AM438_RS07190 1540599..1541885 + 1287 WP_036919265.1 DUF3748 domain-containing protein -
AM438_RS07195 1542102..1542981 + 880 Protein_1365 endonuclease/exonuclease/phosphatase family protein -
AM438_RS07200 1542974..1543408 + 435 WP_004246827.1 hypothetical protein -
AM438_RS07205 1543458..1543778 - 321 WP_004246828.1 helix-turn-helix domain-containing protein Antitoxin
AM438_RS07210 1543771..1544157 - 387 WP_004249093.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AM438_RS07215 1544319..1546391 - 2073 WP_036919263.1 glycine--tRNA ligase subunit beta -
AM438_RS07220 1546401..1547306 - 906 WP_004246832.1 glycine--tRNA ligase subunit alpha -
AM438_RS07225 1547557..1548138 + 582 WP_012368524.1 DNA-3-methyladenine glycosylase I -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-125)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-95)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14294.64 Da        Isoelectric Point: 10.0642

>T73860 WP_004249093.1 NZ_CP020052:c1544157-1543771 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVKYD

Download         Length: 387 bp

>T73860 NZ_CP020052:c1544157-1543771 [Proteus mirabilis]
ATGGTTATTTATAAAACAAAGATGTTCAAAAATAGTTTCAAAAAAATAACGCTTACGAATGCAGAACTAATAGCTATCGC
TACCGAAGTCCTTGCAGGACAATTTGAGGCAGATCTAGGTGGTGGTGTTATCAAGAAACGTGCCTGTATCCAAGGAAAAG
GTAAAAGTAGCGGAATTAGAACAATTATATTTTATAAGCAAGGGAATAATTTATTCTTTGCTGATGGTTGGAAAAAATCG
AGTTTAAGCTCTAAAAAAACCAAAGAGATCACAGATGATGAACTTGAGTCCTATAAAGATCTAGCAAAAGATCTCTTCAA
TGCAAATCAAAATAAAATAGATAAAATGATTGCACTAGGCCTTTTAACAGAGGTTAAATATGACTGA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12126.21 Da        Isoelectric Point: 10.4411

>AT73860 WP_004246828.1 NZ_CP020052:c1543778-1543458 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Download         Length: 321 bp

>AT73860 NZ_CP020052:c1543778-1543458 [Proteus mirabilis]
ATGACTGATAAAATGAAAGAAATGCTAAAATTTGCACAAGAAATGGAAGATGCAGGAGTCACTGATGGCAGTACAACTAA
ACGTATTGCCGCCAGAATAAAAGCGAAAGAATTACAAGCTAAGTATAAACATCCTACCCCTATGACAGGTGAAGATATAA
AAAGGATCCGTGAGCAAAATAATATCTCTCAATCTTCCCTTGCTTTGATATTGAATATGACTAAAGAAAGCGTTTCTAAG
TGGGAAAGAAACGAAATTAAGCCCAATGGTGCAGCACTACGACTTCTTCATTTAATAGATAAAAAAATATTATTCATCTA
G

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B4EZ96

Antitoxin

Source ID Structure
AlphaFold DB B4EZ97

References