Detailed information of TA system TA073860

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-MqsA
• Location: 1543458..1544157
• Replicon: chromosome
• Accession: NZ_CP020052
• Organism: Proteus mirabilis strain AR_0059

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B4EZ96
• Locus tag: AM438_RS07210
• Protein ID: WP_004249093.1
• Coordinates: 1543771..1544157 (-)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B4EZ97
• Locus tag: AM438_RS07205
• Protein ID: WP_004246828.1
• Coordinates: 1543458..1543778 (-)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AM438_RS07175	1538590..1538865	-	276	WP_004246820.1	DNA-directed RNA polymerase subunit omega	-
AM438_RS07180	1538920..1539543	-	624	WP_049211625.1	guanylate kinase	-
AM438_RS07185	1539845..1540462	-	618	WP_004246822.1	trimeric intracellular cation channel family protein	-
AM438_RS07190	1540599..1541885	+	1287	WP_036919265.1	DUF3748 domain-containing protein	-
AM438_RS07195	1542102..1542981	+	880	Protein_1365	endonuclease/exonuclease/phosphatase family protein	-
AM438_RS07200	1542974..1543408	+	435	WP_004246827.1	hypothetical protein	-
AM438_RS07205	1543458..1543778	-	321	WP_004246828.1	helix-turn-helix domain-containing protein	Antitoxin
AM438_RS07210	1543771..1544157	-	387	WP_004249093.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AM438_RS07215	1544319..1546391	-	2073	WP_036919263.1	glycine--tRNA ligase subunit beta	-
AM438_RS07220	1546401..1547306	-	906	WP_004246832.1	glycine--tRNA ligase subunit alpha	-
AM438_RS07225	1547557..1548138	+	582	WP_012368524.1	DNA-3-methyladenine glycosylase I	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-125)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-95)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14294.64 Da
• Isoelectric Point: 10.0642

>T73860 WP_004249093.1 NZ_CP020052:c1544157-1543771 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVKYD

Nucleotide

• Length: 387 bp

>T73860 NZ_CP020052:c1544157-1543771 [Proteus mirabilis]
ATGGTTATTTATAAAACAAAGATGTTCAAAAATAGTTTCAAAAAAATAACGCTTACGAATGCAGAACTAATAGCTATCGC
TACCGAAGTCCTTGCAGGACAATTTGAGGCAGATCTAGGTGGTGGTGTTATCAAGAAACGTGCCTGTATCCAAGGAAAAG
GTAAAAGTAGCGGAATTAGAACAATTATATTTTATAAGCAAGGGAATAATTTATTCTTTGCTGATGGTTGGAAAAAATCG
AGTTTAAGCTCTAAAAAAACCAAAGAGATCACAGATGATGAACTTGAGTCCTATAAAGATCTAGCAAAAGATCTCTTCAA
TGCAAATCAAAATAAAATAGATAAAATGATTGCACTAGGCCTTTTAACAGAGGTTAAATATGACTGA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12126.21 Da
• Isoelectric Point: 10.4411

>AT73860 WP_004246828.1 NZ_CP020052:c1543778-1543458 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Nucleotide

• Length: 321 bp

>AT73860 NZ_CP020052:c1543778-1543458 [Proteus mirabilis]
ATGACTGATAAAATGAAAGAAATGCTAAAATTTGCACAAGAAATGGAAGATGCAGGAGTCACTGATGGCAGTACAACTAA
ACGTATTGCCGCCAGAATAAAAGCGAAAGAATTACAAGCTAAGTATAAACATCCTACCCCTATGACAGGTGAAGATATAA
AAAGGATCCGTGAGCAAAATAATATCTCTCAATCTTCCCTTGCTTTGATATTGAATATGACTAAAGAAAGCGTTTCTAAG
TGGGAAAGAAACGAAATTAAGCCCAATGGTGCAGCACTACGACTTCTTCATTTAATAGATAAAAAAATATTATTCATCTA
G

Structures

Toxin

• AlphaFold DB: B4EZ96

Antitoxin

• AlphaFold DB: B4EZ97