Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1557921..1558708 Replicon chromosome
Accession NZ_CP020046
Organism Thiomonas intermedia strain ATCC 15466

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag BVH73_RS07340 Protein ID WP_079417463.1
Coordinates 1557921..1558424 (-) Length 168 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag BVH73_RS07345 Protein ID WP_079417465.1
Coordinates 1558421..1558708 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BVH73_RS07320 1554256..1555917 - 1662 WP_079417455.1 tetratricopeptide repeat-containing glycosyltransferase family protein -
BVH73_RS07325 1555868..1556632 + 765 WP_079417457.1 SDR family NAD(P)-dependent oxidoreductase -
BVH73_RS07330 1556664..1556954 + 291 WP_079417459.1 antibiotic biosynthesis monooxygenase -
BVH73_RS07335 1557078..1557512 + 435 WP_079417461.1 hypothetical protein -
BVH73_RS07340 1557921..1558424 - 504 WP_079417463.1 GNAT family N-acetyltransferase Toxin
BVH73_RS07345 1558421..1558708 - 288 WP_079417465.1 DUF1778 domain-containing protein Antitoxin
BVH73_RS15730 1558877..1559146 - 270 WP_154048529.1 ATP-binding protein -
BVH73_RS07355 1559219..1559566 - 348 WP_079420431.1 type II toxin-antitoxin system PemK/MazF family toxin -
BVH73_RS07360 1559580..1559774 - 195 WP_079420433.1 hypothetical protein -
BVH73_RS07370 1560345..1561664 + 1320 WP_169836763.1 OprD family outer membrane porin -
BVH73_RS07375 1561677..1562735 + 1059 WP_079417471.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-145)

Antitoxin

Vibrio phage ICP1, Orf50

(12-88)


Sequences

Toxin        


Download         Length: 168 a.a.        Molecular weight: 18571.30 Da        Isoelectric Point: 7.9451

>T73831 WP_079417463.1 NZ_CP020046:c1558424-1557921 [Thiomonas intermedia]
MSLSAPQPLDAHHRVEAFDCGKPALTDWLLRHARQAHGSGSARTFVLCDGERVAGYYSLTVGQIDTLEAPERIRRGMGQY
PIPLVILARLAVDLDYQGRGLGFSLLQDAIRRTLAIAEQAGIRALLTHPIDASAEAFYRRFGFEPMPENERQLILLLKDA
RRHAGQL

Download         Length: 504 bp

>T73831 NZ_CP020046:c1558424-1557921 [Thiomonas intermedia]
ATGAGCCTGTCCGCACCGCAGCCGCTTGACGCGCATCATCGGGTGGAAGCGTTTGACTGCGGGAAACCTGCGCTCACCGA
TTGGCTGCTACGCCATGCCCGCCAGGCCCACGGCAGTGGCTCGGCCCGAACCTTTGTCCTGTGCGACGGGGAGCGGGTGG
CTGGCTACTACAGTCTGACCGTCGGCCAGATCGACACGCTCGAGGCGCCCGAGCGGATTCGTCGTGGCATGGGGCAGTAT
CCGATCCCGCTGGTCATCCTGGCGAGGCTTGCTGTTGATCTCGACTACCAGGGGCGCGGCCTCGGTTTCAGTCTGCTGCA
GGATGCCATCCGGCGCACCCTCGCGATTGCCGAACAGGCGGGAATCCGAGCGCTGCTGACGCACCCCATCGACGCCAGTG
CCGAGGCGTTCTATCGTCGCTTCGGCTTCGAGCCCATGCCAGAGAACGAGCGGCAACTGATCTTGCTGCTCAAGGATGCG
CGGCGTCACGCGGGGCAGCTATGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10523.91 Da        Isoelectric Point: 5.8064

>AT73831 WP_079417465.1 NZ_CP020046:c1558708-1558421 [Thiomonas intermedia]
MTAATSTARTARLGLRATPEQETVLRRAAEVAHKSLTDFVLDAAYQAAEQTLLDQRLFMVSGSQYQAILDMLDRPESDNP
GLADLFSRRPVWATK

Download         Length: 288 bp

>AT73831 NZ_CP020046:c1558708-1558421 [Thiomonas intermedia]
ATGACCGCAGCCACTTCCACAGCGCGCACCGCTCGACTCGGGCTGCGCGCGACCCCTGAACAGGAAACCGTGCTGCGCCG
CGCCGCTGAAGTCGCGCACAAGTCGCTGACGGATTTCGTGCTCGACGCGGCCTACCAGGCCGCAGAACAGACCTTGCTCG
ACCAGCGATTGTTCATGGTTTCCGGTAGCCAGTACCAGGCGATCCTCGATATGCTGGATCGGCCGGAATCCGACAACCCT
GGTTTGGCCGATCTGTTCTCCCGACGCCCGGTCTGGGCCACTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References