Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-couple_hipB
Location 445868..446490 Replicon chromosome
Accession NZ_CP020046
Organism Thiomonas intermedia strain ATCC 15466

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag BVH73_RS02025 Protein ID WP_079415646.1
Coordinates 445868..446125 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag BVH73_RS02030 Protein ID WP_079415647.1
Coordinates 446122..446490 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BVH73_RS01980 441221..441892 + 672 WP_154048399.1 helix-turn-helix domain-containing protein -
BVH73_RS01985 441889..442617 + 729 WP_079415638.1 hypothetical protein -
BVH73_RS01990 442614..443453 + 840 WP_079415639.1 hypothetical protein -
BVH73_RS01995 443622..443882 + 261 WP_079415641.1 hypothetical protein -
BVH73_RS02000 443879..444487 + 609 WP_079415642.1 hypothetical protein -
BVH73_RS02005 444520..444828 + 309 WP_079415643.1 hypothetical protein -
BVH73_RS02010 444895..445179 + 285 WP_079415645.1 hypothetical protein -
BVH73_RS02020 445453..445677 - 225 Protein_388 integrase -
BVH73_RS02025 445868..446125 + 258 WP_079415646.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BVH73_RS02030 446122..446490 + 369 WP_079415647.1 helix-turn-helix transcriptional regulator Antitoxin
BVH73_RS02035 446595..447761 - 1167 WP_079415648.1 DUF2399 domain-containing protein -
BVH73_RS02040 447758..451201 - 3444 WP_079415649.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 326390..459962 133572


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-75)

Antitoxin

Cro/C1-type helix-turn-helix domain

(66-120)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9712.24 Da        Isoelectric Point: 10.4346

>T73829 WP_079415646.1 NZ_CP020046:445868-446125 [Thiomonas intermedia]
MYSIEYSREAFKSLKAMPRNLATTVREKIEQLAAAPHGPNNNVKKLQGRPGYRLRVGDWRVIYEIHDDRLVVMILAVSPR
GGAYQ

Download         Length: 258 bp

>T73829 NZ_CP020046:445868-446125 [Thiomonas intermedia]
ATGTACTCGATCGAATACAGTCGCGAGGCGTTCAAGAGCCTCAAGGCCATGCCACGCAATCTTGCAACGACGGTGCGCGA
AAAGATCGAACAGTTGGCAGCTGCGCCCCACGGACCGAACAACAACGTGAAGAAGCTGCAAGGGCGCCCTGGCTATCGAT
TGCGCGTCGGCGATTGGCGCGTGATTTACGAAATTCATGATGACCGCCTGGTGGTGATGATCCTTGCGGTTTCCCCACGA
GGAGGTGCGTACCAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13274.31 Da        Isoelectric Point: 8.4495

>AT73829 WP_079415647.1 NZ_CP020046:446122-446490 [Thiomonas intermedia]
MSTIQYIERNGKREYAVVPMELFARLMRAAESLDDVALFDAVKAADDGFRVPGAVAHAILDGIHPVKAWREYRGFTQDAL
AEKAGISKAYLSQIETGKRIGVAKTLKALASALGVTLNELQP

Download         Length: 369 bp

>AT73829 NZ_CP020046:446122-446490 [Thiomonas intermedia]
ATGAGCACGATTCAATACATCGAACGCAACGGGAAACGAGAATACGCCGTGGTTCCGATGGAGTTGTTTGCGCGGTTGAT
GCGCGCCGCCGAGAGCCTGGACGACGTGGCCCTGTTCGATGCCGTGAAAGCTGCTGACGACGGATTTCGGGTCCCTGGTG
CAGTCGCCCATGCCATCCTTGACGGGATCCATCCCGTCAAGGCCTGGCGCGAATATCGCGGATTCACTCAGGACGCTTTG
GCCGAGAAGGCCGGTATCAGCAAGGCCTATCTCAGCCAGATCGAAACGGGCAAGCGGATCGGAGTGGCTAAAACCCTCAA
AGCCCTCGCATCGGCACTGGGCGTGACGCTCAATGAGCTCCAGCCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References