Detailed information of TA system TA073827

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 5254575..5255100
• Replicon: chromosome
• Accession: NZ_CP020039
• Organism: Streptomyces sp. 3211 isolate 3

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: B4U39_RS24565
• Protein ID: WP_079406000.1
• Coordinates: 5254575..5254838 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: S5UWF1
• Locus tag: B4U39_RS24570
• Protein ID: WP_019434848.1
• Coordinates: 5254831..5255100 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B4U39_RS24545	5250896..5251891	+	996	WP_053171450.1	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	-
B4U39_RS24550	5251907..5252659	+	753	WP_203349287.1	ROK family protein	-
B4U39_RS24555	5252694..5253086	-	393	WP_052876514.1	hypothetical protein	-
B4U39_RS24560	5253353..5254441	+	1089	WP_030385825.1	redox-regulated ATPase YchF	-
B4U39_RS24565	5254575..5254838	-	264	WP_079406000.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
B4U39_RS24570	5254831..5255100	-	270	WP_019434848.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
B4U39_RS24575	5255248..5255829	-	582	WP_079406001.1	Uma2 family endonuclease	-
B4U39_RS24580	5255971..5258064	-	2094	WP_079406002.1	N-6 DNA methylase	-
B4U39_RS24585	5258465..5258845	+	381	WP_079406003.1	PadR family transcriptional regulator	-
B4U39_RS24590	5258842..5259399	+	558	WP_079406004.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-58)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10050.53 Da
• Isoelectric Point: 9.5559

>T73827 WP_079406000.1 NZ_CP020039:c5254838-5254575 [Streptomyces sp. 3211]
VSEYRTVFRPEARAELRKVPRDMALRILAKLTELESDPLGLNTTALVSQPERRRLRVGDYRVVYTIDNGELVVWVVHVGH
RSTVYDT

Nucleotide

• Length: 264 bp

>T73827 NZ_CP020039:c5254838-5254575 [Streptomyces sp. 3211]
GTGAGTGAGTACCGAACCGTCTTCCGCCCCGAGGCGCGGGCCGAGCTTCGGAAGGTCCCTCGCGACATGGCCCTGCGCAT
CCTGGCCAAGCTGACCGAGCTGGAGAGCGATCCCCTCGGCCTCAACACCACCGCGCTCGTGTCGCAGCCGGAACGCCGTC
GACTGCGAGTCGGCGACTACCGCGTCGTCTACACGATCGACAACGGGGAGCTCGTGGTGTGGGTCGTACACGTCGGGCAT
CGCTCCACCGTTTACGACACCTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10259.71 Da
• Isoelectric Point: 4.6265

>AT73827 WP_019434848.1 NZ_CP020039:c5255100-5254831 [Streptomyces sp. 3211]
MTQPLPIESIRDVRAHLAEVVERADRDDVPTVITRRGKEVAAVVSIEVLRKYQEWEEREINRIIDERMANPAPGIPIEDI
MRETLARGE

Nucleotide

• Length: 270 bp

>AT73827 NZ_CP020039:c5255100-5254831 [Streptomyces sp. 3211]
ATGACGCAGCCGCTCCCCATAGAGTCCATCCGCGACGTGCGCGCCCACCTGGCGGAAGTCGTGGAGCGCGCGGACCGCGA
CGACGTACCCACAGTCATCACCCGCCGAGGTAAGGAAGTCGCCGCCGTCGTCTCCATCGAGGTGCTGCGCAAATACCAGG
AGTGGGAAGAGCGCGAGATCAACCGGATCATCGACGAGCGCATGGCCAACCCCGCACCCGGCATCCCGATCGAGGACATC
ATGAGGGAGACGCTGGCGCGCGGTGAGTGA

Structures

Antitoxin

• AlphaFold DB: S5UWF1